Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Szczepan W Baran"'
Autor:
Brian R. Berridge, Szczepan W. Baran, Vivek Kumar, Natalie Bratcher-Petersen, Michael Ellis, Chang-Ning Liu, Timothy L. Robertson
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Though the portfolio of medicines that are extending and improving the lives of patients continues to grow, drug discovery and development remains a challenging business on its best day. Safety liabilities are a significant contributor to development
Externí odkaz:
https://doaj.org/article/ad27030667f84b9e82a29fe81d79692c
Autor:
Szczepan W. Baran, Natalie Bratcher, John Dennis, Stefano Gaburro, Eleanor M. Karlsson, Sean Maguire, Paul Makidon, Lucas P. J. J. Noldus, Yohann Potier, Giorgio Rosati, Matt Ruiter, Laura Schaevitz, Patrick Sweeney, Megan R. LaFollette
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2022)
In drug discovery and development, traditional assessment of human patients and preclinical subjects occurs at limited time points in potentially stressful surroundings (i.e., the clinic or a test arena), which can impact data quality and welfare. Ho
Externí odkaz:
https://doaj.org/article/f2ff9157c2e846a6bf25eae799dfab90
Autor:
Szczepan W. Baran, Ayan Das Gupta, Maria A. Lim, Ashwini Mathur, David J. Rowlands, Laura R. Schaevitz, Shiva K. Shanmukhappa, Dana B. Walker
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Assessments of respiratory response and animal activity are useful endpoints in drug pharmacology and safety research. We investigated whether continuous, direct monitoring of breathing rate and body motion in animals in the home cage using the Vum D
Externí odkaz:
https://doaj.org/article/3b33a2f40f484891a9c601e0ab928f3e
Autor:
Babatunde Bello, Yogesh N. Bundey, Roshan Bhave, Maksim Khotimchenko, Szczepan W. Baran, Kaushik Chakravarty, Jyotika Varshney
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6250
The COVID-19 pandemic has presented an unprecedented challenge to the healthcare system. Identifying the genomics and clinical biomarkers for effective patient stratification and management is critical to controlling the spread of the disease. Omics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b591ce617840a3fda44161e0b2732c
Autor:
Szczepan W, Baran, Paul C, Brown, Andreas R, Baudy, Suzanne C, Fitzpatrick, Christopher, Frantz, Aaron, Fullerton, Jinping, Gan, Rhiannon N, Hardwick, Kathleen M, Hillgren, Anna K, Kopec, Jennifer L, Liras, Donna L, Mendrick, Ryan, Nagao, William R, Proctor, Diane, Ramsden, Alexandre J S, Ribeiro, David, Stresser, Kyung E, Sung, Radhakrishna, Sura, Kazuhiro, Tetsuka, Lindsay, Tomlinson, Terry, Van Vleet, Matthew P, Wagoner, Qin, Wang, Sevim Yildiz, Arslan, Gorm, Yoder, Jason E, Ekert
Publikováno v:
ALTEX.
Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug attrition due to safety and/ or efficacy concerns. For this technology to have an impact, the establishment of robust characterization and qualification plan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991b82190055f9a932fb29fb1692bafd
https://doi.org/10.14573/altex.2112203
https://doi.org/10.14573/altex.2112203
Autor:
Kevin S. W. Tan, Kate Breyer, Georges Snounou, Clemens H. M. Kocken, Anne Elliot, Bruce Russell, Varakorn Kosaisavee, Bryan K. S. Yeung, Bee Huat Tan, Adeline C. Y. Chua, Rossarin Suwanarusk, Siti Nurdiana Abas, Rou Zhang, Anne-Marie Zeeman, Jee Sun Cho, Benoit Malleret, Laurent Rénia, Roger Le Grand, Dennis E. Kyle, Mary R. Galinski, Christophe Bodenreider, Nathalie Dereuddre-Bosquet, Chester J. Joyner, François Nosten, Dominique Mazier, Szczepan W Baran, Pablo Bifani, Amber Lange, Jessica Jie Ying Ong, Thierry T. Diagana, Steven P. Maher, Caitlin A. Cooper, Andy M. Yip
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
The ability to culture pathogenic organisms substantially enhances the quest for fundamental knowledge and the development of vaccines and drugs. Thus, the elaboration of a protocol for the in vitro cultivation of the erythrocytic stages of Plasmodiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fd9b03ad20049d99276309712f02ba
https://hal.archives-ouvertes.fr/hal-02347287
https://hal.archives-ouvertes.fr/hal-02347287
Autor:
Aravind Ramakrishnan, Lynn Graf, Brian Hayes, Sara R. Fagerlie, Ausra Bendoraite, Merav Bar, Szczepan W. Baran, Beverly Torok-Storb, Muneesh Tewari, Michael A. Harkey
Publikováno v:
Stem Cells. 26:465-473
Embryonic stem (ES) cells have created considerable excitement in the last few years due to their unlimited potential to produce cells for tissue repair and replacement. However, a large animal pre-clinical model is necessary to establish the safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e5b2edb318e62132cbe6d7e087992a
https://doi.org/10.1634/stemcells.2007-0640
https://doi.org/10.1634/stemcells.2007-0640
Autor:
Szczepan W. Baran, Carol B. Ware
Publikováno v:
Stem Cells and Development. 16:339-344
Studies using nonhuman primate embryonic stem (ES) cells will facilitate the translation of basic ES cell research to clinical use by providing a large animal model for in vivo testing. Unfortunately, nonhuman primate ES cells do not survive well fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058e6fa46755272e256506e879d5fdd1
https://doi.org/10.1089/scd.2007.900-de
https://doi.org/10.1089/scd.2007.900-de
Autor:
Paula, Clifford, Natasha, Melfi, John, Bogdanske, Elizabeth J, Johnson, James, Kehler, Szczepan W, Baran
Publikováno v:
Journal of the American Association for Laboratory Animal Science : JAALAS. 52(6)
Personnel working with laboratory animals are required by laws and guidelines to be trained and qualified to perform biomethodologic procedures. The assessment of competency and proficiency is a vital component of a laboratory animal training program
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4f4a4c2dbb065b428702b508e527a03
https://pubmed.ncbi.nlm.nih.gov/24351758
https://pubmed.ncbi.nlm.nih.gov/24351758
Publikováno v:
Journal of the American Association for Laboratory Animal Science : JAALAS. 49(3)
The development of new rodent models of human disease and advances in surgical equipment and technologies have increased the demand for expertise in rodent surgery. Because of the limited availability of rodent surgical training courses, electronic (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be0a2d10dbe3c296fe891359908a754c
https://pubmed.ncbi.nlm.nih.gov/20587161
https://pubmed.ncbi.nlm.nih.gov/20587161