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Changes in Environmental Stress over COVID-19 Pandemic Likely Contributed to Failure to Replicate Adiposity Phenotype Associated withKrtcap3

Autor: Szalanczy, Alexandria M, Giorgio, Gina, Goff, Emily, Seshie, Ozzie, Grzybowski, Michael, Klotz, Jason, Geurts, Aron M, Redei, Eva E, Woods, Leah C Solberg

Publikováno v: bioRxiv

We previously identifiedKeratinocyte-associated protein 3, Krtcap3,as an obesity-related gene in female rats where a whole-bodyKrtcap3knock-out (KO) led to increased adiposity compared to wild-type (WT) controls when fed a high-fat diet (HFD). We sou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1470830cb453323c8b82e366968e56f8
https://doi.org/10.1101/2023.03.15.532439

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Keratinocyte-associated protein 3 plays a role in body weight and adiposity with differential effects in males and females.

Autor: Szalanczy AM; Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, NC, United States., Goff E; Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, NC, United States., Seshie O; Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, NC, United States., Deal A; Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, NC, United States., Grzybowski M; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States., Klotz J; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States., Chuang Key CC; Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, NC, United States., Geurts AM; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States., Solberg Woods LC; Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, NC, United States.

Publikováno v: Frontiers in genetics [Front Genet] 2022 Sep 21; Vol. 13, pp. 942574. Date of Electronic Publication: 2022 Sep 21 (Print Publication: 2022).