Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats.

Autor: Ostrowski LA; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Hall AC; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Szafranski KJ; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Oshidari R; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Abraham KJ; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Chan JNY; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Krustev C; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Zhang K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Wang A; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Liu Y; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Guo R; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Mekhail K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada. karim.mekhail@utoronto.ca.; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 1M1, Canada. karim.mekhail@utoronto.ca.

Publikováno v: Communications biology [Commun Biol] 2018 Nov 05; Vol. 1, pp. 187. Date of Electronic Publication: 2018 Nov 05 (Print Publication: 2018).