Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Szabolcs Orosz"'
Autor:
György Lévay, Balázs Lendvai, Szabolcs Orosz, Bence Farkas, Péter Kardos, Peter Kovacs, István Tarnawa, Csongor Csekő, Sándor Farkas
Publikováno v:
Brain Research. 1625:287-300
The trigeminovascular system has a pivotal role in the pathomechanism of migraine. The aim of the present study was to further develop existing models of migraine making them more suitable for testing the effects of compounds with presumed antimigrai
Autor:
Attila S. Farkas, Péter Kui, Csongor Csekő, Tamás Forster, Szabolcs Orosz, András Farkas, Norbert Csík, Ferenc Rárosi, Hedvig Takács, Julius Gy. Papp, András Varró, Annamária Sarusi
Publikováno v:
Journal of pharmacological and toxicological methods. 80
Introduction Preclinical in vivo QT measurement as a proarrhythmia essay is expensive and not reliable enough. The aim of the present study was to develop a sensitive, cost-effective, Langendorff perfused guinea pig heart model for proarrhythmia safe
Autor:
Tamás Forster, Szabolcs Orosz, Attila S. Farkas, Norbert Csík, Ferenc Fülöp, András Farkas, Michael J. Shattock, Julius Gy. Papp, Miklós Csanády, András Varró, Péter Makra
Publikováno v:
British Journal of Pharmacology. 156:920-932
Background and purpose: The Na+/Ca2+ exchanger (NCX) may contribute to triggered activity and transmural dispersion of repolarization, which are substrates of torsades de pointes (TdP) type arrhythmias. This study examined the effects of selective in
Autor:
Tamás Forster, Szabolcs Orosz, András Tóth, András Farkas, László Dézsi, Julius Gy. Papp, Attila S. Farkas, Károly Acsai, Miklós Csanády, András Varró
Publikováno v:
European Journal of Pharmacology. 537:118-125
In anaesthetized rabbits, alpha(1)-adrenoceptor stimulation increases the propensity of repolarization-prolonging drugs to induce torsade de pointes ventricular tachycardia. However, it is not known whether the stimulation of intracardiac alpha(1)-ad
Autor:
Attila S. Farkas, András Varró, András Farkas, Julius Gy. Papp, Sándor Farkas, Tamás Forster, Szabolcs Orosz, Norbert Csík, Annamária Sarusi
Publikováno v:
Journal of cardiovascular pharmacology. 64(3)
Isolated hearts with reduced repolarization reserve would be suitable for assessing the proarrhythmic liability of drugs. However, it is not known which proarrhythmia biomarkers indicate the increased susceptibility to torsades de pointes arrhythmia
Autor:
Szabolcs Orosz, András Varró, Péter Makra, Norbert Csík, László Rudas, István Leprán, András Farkas, Attila Farkas
Publikováno v:
Journal of Molecular and Cellular Cardiology. 42:S6
Autor:
Attila S. Farkas, Tamás Forster, Szabolcs Orosz, András Varró, Miklós Csanády, András Farkas, Julius Gy. Papp
Publikováno v:
Journal of Molecular and Cellular Cardiology. 42:S4
Delayed afterdepolarizations (DADs) induced by the electrogenic Na/Ca exchanger (NCX) play an important role in the genesis of arrhythmias. However, it is not known whether the NCX-induced DADs play any role in the genesis of the repolarization prolo
Autor:
András Farkas, András Varró, Julius Gy. Papp, Miklós Csanády, László Rudas, Attila S. Farkas, Tamás Forster, Szabolcs Orosz, Norbert Csík, István Leprán
Publikováno v:
Journal of Molecular and Cellular Cardiology. 40:984
1643 activated human HERG channels in a heterologous expression system, whereas Na and Ca-channels were not blocked by the agent. Here we describe the effects of NS1643 on force of contraction and action potential parameters in isolated guinea pig pa