Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A

Autor: Stéphanie Chhun, Yanick J. Crow, Henna Tyynismaa, Bert Callewaert, Gillian I. Rice, Manju A Kurian, Christine Bodemer, Edwin Carter, Lien De Somer, Luis Seabra, Simon Holden, Hugh J. McMillan, Brigitte Bader-Meunier, Kristin Suetens, Timothy Wai, Lucy Grove, Sylvie Fraitag, Erika Della Mina, Ashish Dhir, Fran Faes, Marie Hully, Mathieu P Rodero, Pascale de Lonlay, Marie-Louise Frémond, Alice Lepelley, Daniela Buhas, David A. Dyment, Carine Wouters, Erika Van Nieuwenhove, Lise Waumans

Publikováno v: Lepelley, A, Mina, E D, Nieuwenhove, E V, Waumans, L, Fraitag, S, Rice, G I, Dhir, A, Frémond, M-L, Rodero, M P, Seabra, L, Carter, E, Bodemer, C, Buhas, D, Callewaert, B, Lonlay, P D, Somer, L D, Dyment, D A, Faes, F, Grove, L, Holden, S, Hully, M, Kurian, M A, McMillan, H J, Suetens, K, Tyynismaa, H, Chhun, S, Wai, T, Wouters, C, Bader-Meunier, B & Crow, Y J 2021, ' Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A ', Journal of Experimental Medicine, vol. 218, no. 10, e20201560 . https://doi.org/10.1084/jem.20201560
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (10), pp.e20201560. ⟨10.1084/jem.20201560⟩
Journal of Experimental Medicine, 2021, 218 (10), pp.e20201560. ⟨10.1084/jem.20201560⟩
Lepelley, A, Della Mina, E, Van Nieuwenhove, E, Waumans, L, Fraitag, S, Rice, G I, Dhir, A, Frémond, M-L, Rodero, M P, Seabra, L, Carter, E, Bodemer, C, Buhas, D, Callewaert, B, de Lonlay, P, De Somer, L, Dyment, D A, Faes, F, Grove, L, Holden, S, Hully, M, Kurian, M A, McMillan, H J, Suetens, K, Tyynismaa, H, Chhun, S, Wai, T, Wouters, C, Bader-Meunier, B & Crow, Y J 2021, ' Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A ', Journal of Experimental Medicine . https://doi.org/10.1084/jem.20201560
JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial DNA (mtDNA) has been suggested to drive immune system activation, but the induction of interferon signaling by mtDNA has not been demonstrated in a Mendelian mitochondrial disease. We initially ascertained two patients, one with a purel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535a86644148a93958b751d60959fb97
https://pure.manchester.ac.uk/ws/files/211719510/jem_20201560.pdf

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

Autor: Charlotte Möller, Gregory J. Buchan, Francisco J. Schopfer, Rachel E. Rigby, Hiroyuki Arai, Jonathan J. Miner, Wei Qian, Anne L. Thielke, Camilla Gunderstofte, Martin R. Jakobsen, Jan Rehwinkel, Jessica Roos, Mona Motwani, Sonia R. Salvatore, Katherine A. Fitzgerald, Marie B. Iversen, Rongtuan Lin, Raphaela Goldbach-Mansky, Christian K. Holm, Michael Rühl, Kojiro Mukai, Thorsten J. Maier, Tomohiko Taguchi, Cathrine A. Miner, Andreas S. Jakobsen, Anne-Louise S. Hansen, Emari Ogawa, David Olagnier, Sidsel D. Andersen

Publikováno v: Hansen, A L, Buchan, G J, Rühl, M, Mukai, K, Salvatore, S R, Ogawa, E, Andersen, S D, Iversen, M B, Thielke, A L, Gunderstofte, C, Motwani, M, Møller, C T, Jakobsen, A S, Fitzgerald, K A, Roos, J, Lin, R, Maier, T J, Goldbach-Mansky, R, Miner, C A, Qian, W, Miner, J J, Rigby, R E, Rehwinkel, J, Jakobsen, M R, Arai, H, Taguchi, T, Schopfer, F J, Olagnier, D & Holm, C K 2018, ' Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 33, pp. E7768-E7775 . https://doi.org/10.1073/pnas.1806239115
Proceedings of the National Academy of Sciences of the United States of America

Significance Several chronic inflammatory conditions have recently been shown to depend on abnormally high activity of the signaling protein stimulator of IFN genes (STING). These conditions include examples from systemic lupus erythematosus, Aicardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7de5e98d88f9543f4ef4e8fec446d2
https://doi.org/10.1073/pnas.1806239115

Type I interferonopathies in pediatric rheumatology

Autor: Volpi, S., Picco, P., Caorsi, R., Candotti, F., Gattorno, M.

Publikováno v: Pediatric rheumatology online journal, vol. 14, no. 1, pp. 35

Defective regulation of type I interferon response is associated with severe inflammatory phenotypes and autoimmunity. Type I interferonopathies are a clinically heterogenic group of Mendelian diseases with a constitutive activation of this pathway t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::6259d649ae88c66ae8976fb1d7306c11
https://serval.unil.ch/notice/serval:BIB_F53B15A22E70

Genetic susceptibility to PolyI:C-induced IFNα/β-dependent accelerated disease in lupus-prone mice

Autor: B. L. Kotzin, Michael T. Falta, Trine N. Jørgensen, Johne Kappler, Pilippa Marrack, S. A. Flannery, Troy E. Metzger, Shozo Izui, Joshua M. Thurman

Publikováno v: Genes and Immunity, Vol. 7, No 7 (2006) pp. 555-567

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology. Associations between viral infections and the onset of SLE have been suggested, and recent studies have provided evidence that type I interferons (IFNalpha/beta) might p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861c38bc875c34fa163cebeda313413c
https://doi.org/10.1038/sj.gene.6364329

A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus

Autor: Chenghui Huang, Susan Yung, Gongping Liang, Qianjin Lu, Rong Xiao, Tak Mao Chan, Ming Zhao, Yaping Li

Publikováno v: Clinical and Developmental Immunology, Vol 2013 (2013)
Clinical and Developmental Immunology

The aberrant activity of CD4(+) T cells in patients with systemic lupus erythematosus (SLE) is associated with DNA hypomethylation of the regulatory regions in CD11a and CD70 genes. Our previous studies demonstrated that Gadd45a contributes to the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6eaff4ae16a1eb0f04d31df934380a
https://doaj.org/article/b31b71eb425743c796350ff07b7cb2d1