Výsledky vyhledávání - "Syouko Tatsuyama"

DX-9065a inhibits proinflammatory events induced by gingipains and factor Xa

Autor: Munehiro Tomikawa, Ikuro Maruyama, Kenji Matsushita, Syouko Tatsuyama, Takahisa Imamura, Salunya Tancharoen

Publikováno v: Journal of Periodontal Research. 41:148-156

Objective: Arginine-specific cysteine proteases (Rgps) from Porphyromonas gingivalis are important virulent factors of periodontal diseases. However, there is no therapeutic drug that inhibits proinflammatory events induced by these enzymes. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38646994026ce03615e8462b29034f38
https://doi.org/10.1111/j.1600-0765.2005.00853.x

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Autor: Tetsuro Ikebe, Kanemitsu Shirasuna, Tohru Oyama, Kazumasa Sugihara, Takehiro Kajihara, Mahiro Beppu, Mitsuo Torii, Shigetaka Nagaoka, Tetsuya Sakuta, Masayuki Tokuda, Seiko Tabuchi, Syouko Tatsuyama

Publikováno v: Journal of periodontal research. 44(3)

Background and Objective: Matrix metalloproteinase (MMP)-13 has wide substrate specificity compared with other MMPs and appears to be involved in periodontitis. Previously, we reported that roxithromycin (RXM) inhibits vascular endothelial growth fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23937e5543744ac7c3936b481994fccd
https://pubmed.ncbi.nlm.nih.gov/19453496

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Roxithromycin inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-1 expression through regulating mitogen-activated protein kinase phosphorylation and Ets-1 expression

Autor: Kenji Matsushita, Tetsuya Sakuta, Masayuki Tokuda, Mitsuo Torii, Syouko Tatsuyama, Tohru Oyama, Shigetaka Nagaoka

Publikováno v: Journal of periodontal research. 42(1)

Background and Objective: In periodontitis, matrix metalloproteinases (MMPs) are upregulated in response to locally released inflammatory cytokines, resulting in pathologic processes. Roxithromycin is a 14-membered ring macrolide antibiotic with broa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb6da0da9ec98b6d3efeeb9878d6205
https://pubmed.ncbi.nlm.nih.gov/17214640

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Selective inhibition of Porphyromonas gingivalis growth by a factor Xa inhibitor, DX-9065a

Autor: Kenji Matsushita, James Travis, Ikuro Maruyama, Jan Potempa, Munehiro Tomikawa, Salunya Tancharoen, Syouko Tatsuyama, Mitsuo Torii, Takahisa Imamura

Publikováno v: Journal of periodontal research. 41(3)

Background: Porphyromonas gingivalis is a causative bacterium of adult periodontitis. However, there is no drug specific for P. gingivalis and for its virulence factor. Objectives: The objective of this study was to examine the effects of a new selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3c94f6b48a1267074dbfab2c4fdea8
https://pubmed.ncbi.nlm.nih.gov/16677284

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Enhanced expression of vascular endothelial growth factor by periodontal pathogens in gingival fibroblasts

Autor: Miho Machigashira, Syouko Tatsuyama, Mitsuo Torii, Takahisa Imamura, Yuichi Izumi, Kenji Matsushita, Kanyarat Suthin

Publikováno v: Journal of periodontal research. 38(1)

Vascular endothelial growth factor (VEGF) has recently attracted attention as a potent inducer of vascular permeability and angiogenesis. Aberrant angiogenesis is often associated with lesion formation in chronic periodontitis. The aim of the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6fd4095b5077a14e862a052dcfc4b9
https://pubmed.ncbi.nlm.nih.gov/12558942

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