Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Synuclein Family"'
Akademický článek
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Publikováno v:
Acta Neuropathologica. 141:471-490
The SNCA locus currently has an indisputable role in Parkinson's disease and other synucleinopathies. The role of genetic variability in the other members of the synuclein family (SNCB and SNCG) in disease is far less clear. In this review, we critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9176b7347e6eab87e0ef60cb10f5a132
https://doi.org/10.1007/s00401-020-02202-1
https://doi.org/10.1007/s00401-020-02202-1
Autor:
Natalia Ninkina, Owen M. Peters, Natalie Connor-Robson, Kirill D. Chaprov, Holger B. Kramer, Dominic J. Withers, Arthur T. Kopylov, Vladimir L. Buchman, Steven Millership, Alex Montoya
Publikováno v:
The Journal of Biological Chemistry
Synucleins, a family of three proteins highly expressed in neurons, are predominantly known for the direct involvement of α-synuclein in the etiology and pathogenesis of Parkinson's and certain other neurodegenerative diseases, but their precise phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c25bdcdb04d42ed3e6e25fe31cef99
http://europepmc.org/articles/PMC8633583
http://europepmc.org/articles/PMC8633583
Autor:
Natalia Ninkina, Mikhail V. Pokrovskiy, Andrei Yu. Roman, Vladimir L. Buchman, Irina A. Guschina
Publikováno v:
Molecules
Volume 26
Issue 11
Molecules, Vol 26, Iss 3078, p 3078 (2021)
Volume 26
Issue 11
Molecules, Vol 26, Iss 3078, p 3078 (2021)
Background: Recent studies have implicated synucleins in several reactions during the biosynthesis of lipids and fatty acids in addition to their recognised role in membrane lipid binding and synaptic functions. All members of the synuclein family in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c0ba58a56eeb31beb60c84bb706ade
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Geert Callewaert, Petra D’hooge, Tien-Yang Ma, Mara Del Vecchio, Vincent Van Eyck, Vanessa Franssens, Joris Winderickx
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The yeast Saccharomyces cerevisiae is a powerful model to study the molecular mechanisms underlying α-synuclein (α-syn) cytotoxicity. This is due to the high degree of conservation of cellular processes with higher eukaryotes and the fact that yeas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd743c5f9c2eae60c2fb935c5c7d023
https://doi.org/10.3389/fgene.2020.00266
https://doi.org/10.3389/fgene.2020.00266
Autor:
R. K. Ovchinnikov, Sergey Morozov, Ekaterina V. Teterina, Kirill D. Chaprov, Valeria V. Goloborshcheva, Valeriayn Kucheryanu
Publikováno v:
Neuroscience for Medicine and Psychology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::823695987c65a352d852432371014d0b
https://doi.org/10.29003/m1325.sudak.ns2020-16/505-506
https://doi.org/10.29003/m1325.sudak.ns2020-16/505-506
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 1067, p 1067 (2021)
Volume 11
Issue 8
Biomolecules, Vol 11, Iss 1067, p 1067 (2021)
Volume 11
Issue 8
The 140 amino acid protein α-synuclein (αS) is an intrinsically disordered protein (IDP) with various roles and locations in healthy neurons that plays a key role in Parkinson’s disease (PD). Contact with biomembranes can lead to α-helical confo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7945d041e085397996714fcffebe967d
https://doi.org/10.3390/biom11081067
https://doi.org/10.3390/biom11081067
Autor:
Ana Gámez-Valero, Katrin Beyer
Publikováno v:
Genes
Genes, Vol 9, Iss 2, p 63 (2018)
Genes, Vol 9, Iss 2, p 63 (2018)
The synuclein family is composed of three members, two of which, α- and β-synuclein, play a major role in the development of synucleinopathies, including Parkinson’s disease (PD) as most important movement disorder, dementia with Lewy bodies (DLB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0387b1ca8cba60640a10102f3efb1ee4
https://pubmed.ncbi.nlm.nih.gov/29370097
https://pubmed.ncbi.nlm.nih.gov/29370097
Autor:
Alexei Surguchev, Andrei Surguchov
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
Synuclein family consists of three members, alpha, beta and gamma-synuclein which are thoroughly investigated for almost 30 years, because of their involvement in human diseases. Since the first synuclein discovery in the brain of the electric ray To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f7f833dda01e4026e07c5900a109a9
https://doi.org/10.3389/fnmol.2017.00224
https://doi.org/10.3389/fnmol.2017.00224