Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Synthia H. Sun"'
Publikováno v:
Glia. 63:877-893
D-serine is a coagonist of N-methyl-d-aspartate (NMDA) subtype of glutamate receptor and plays a role in regulating activity-dependent synaptic plasticity. In this study, we examined the mechanism by which extracellular ATP triggers the release of d-
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 33:764-773
Adult hippocampal neurogenesis is important for learning and memory, especially after a brain injury such as ischemia. Newborn hippocampal neurons contribute to memory performance by establishing functional synapses with target cells. This study demo
Publikováno v:
Cellular Signalling. 23:1816-1823
Polo-like kinase 1 (Plk1) plays key roles in many aspects of mitosis. We have previously shown that induction of p21 Waf1 by p53 is responsible for protection of cells against adriamycin-induced polyploidy formation and mitotic catastrophe. Here we s
Publikováno v:
Circulation Journal. 75:874-883
Background: The mechanically sensitive volume receptors, primarily located in the venoatrial junction area, are essential for blood volume homeostasis. However, the molecular basis of the volume receptors is still unknown. Methods and Results: We hyp
Publikováno v:
Journal of Neuroscience Research. 89:199-211
Chemokines can be produced by gliomas, which mediate the infiltration of microglia, a characteristic feature of glioma-associated neuropathogenesis. ATP that is released at a high level from glioma has been reported to play a regulatory role in chemo
Publikováno v:
Journal of Neurochemistry. 113:213-227
Astrocytes are responsible for clearance of extracellular glutamate, primarily through glial-specific glutamate transporter-1 and the Na(+)-dependent glutamate/aspartate transporter (GLAST). After traumatic injury to the CNS, such as spinal cord inju
Publikováno v:
Journal of Neurochemistry. 111:1225-1237
Microglia, the CNS resident macrophages responsible for the clearance of degenerating cellular fragments, are essential to tissue remodeling and repair after CNS injury. ATP can be released in large amounts after CNS injury and may mediate microglial
Autor:
Hsing-Tsen Lu, Tsan-Ting Hsu, Synthia H. Sun, Chia-Ling Chang, Yu-Chia Lin, Dachen Chu, Pei-Yu Wu, Chia-Hsuan Chin
Publikováno v:
Cellular Signalling. 21:881-891
Neuro-2a (N2a) cells are derived from spontaneous neuroblastoma of mouse and capable to differentiate into neuronal-like cells. Recently, P2X7 receptor has been shown to sustain growth of human neuroblastoma cells but its role during neuronal differe
Publikováno v:
Journal of Neurochemistry. 105:151-164
Glutamate clearance by astrocytes is critical for controlling excitatory neurotransmission and ATP is an important mediator for neuron-astrocyte interaction. However, the effect of ATP on glutamate clearance has never been examined. Here we report th
Autor:
Yijuang Chern, Ju Yun Weng, Dennis W. Dickson, Hsing Lin Lai, Synthia H. Sun, Fang Liao, Szu Yi Chou, Pang-Hsien Tu
Publikováno v:
The Journal of Neuroscience. 28:3277-3290
Huntington's disease (HD) is a hereditary neurological disease caused by expended CAG repeats in the HD gene, which codes for a protein called Huntingtin (Htt). The resultant mutant Huntingtin (mHtt) forms aggregates in neurons and causes neuronal dy