Adaptive laboratory evolution of microbial co-cultures for improved metabolite secretion

Autor: Konstantinidis, Dimitrios, Pereira, Filipa, Geissen, Eva‐Maria, Grkovska, Kristina, Kafkia, Eleni, Jouhten, Paula, Kim, Yongkyu, Devendran, Saravanan, Zimmermann, Michael, Patil, Kiran Raosaheb

Publikováno v: Molecular Systems Biology
Konstantinidis, D, Pereira, F, Geissen, E M, Grkovska, K, Kafkia, E, Jouhten, P, Kim, Y, Devendran, S, Zimmermann, M & Patil, K R 2021, ' Adaptive laboratory evolution of microbial co-cultures for improved metabolite secretion ', Molecular Systems Biology, vol. 17, no. 8, e10189 . https://doi.org/10.15252/msb.202010189
Molecular Systems Biology, Vol 17, Iss 8, Pp n/a-n/a (2021)

Adaptive laboratory evolution has proven highly effective for obtaining microorganisms with enhanced capabilities. Yet, this method is inherently restricted to the traits that are positively linked to cell fitness, such as nutrient utilization. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae7013ab69d3069fb0ce216b5bbe3a6
https://cris.vtt.fi/en/publications/96e51208-2881-42f1-8146-62a10491204b

Model-guided development of an evolutionarily stable yeast chassis

Autor: Isabel Rocha, Justyna Nocon, Filipa Pereira, Kiran Raosaheb Patil, Peter Kötter, Miguel Rocha, Paulo Maia, Britta Meyer, Dimitrios Konstantinidis, Paula Jouhten, H. Lopes, Eleni Kafkia

Publikováno v: Molecular Systems Biology, Vol 17, Iss 7, Pp n/a-n/a (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecular Systems Biology

First-principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations. Yet, the theory of model-based chassis design has rarely been put to rigorous experimental te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047d08421f5148236be05af161ba09f4
https://hdl.handle.net/1822/73774

Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway

Autor: Antoine Huet, Vladan Rankovic, David Lopez de la Morena, Burak Bali, Tobias Moser, Thomas Mager, Artur Mittring

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 6, Pp n/a-n/a (2021)
EMBO Molecular Medicine

Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current cochlear implants. Here, we employed fast and very fast variants of the red‐light‐activated channelrhodop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fea90e77152c739dbc46491f8e5fb4
https://doaj.org/article/dc03d51ba17045839a85e1c1f5068567

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

Autor: Annemieke Aartsma-Rus, Marisol Montolio, Gisela Gaina, Camilla Foged, Suzan M. Hammond, Alejandro Garanto, David R. Jones, Lourdes R. Desviat, Giuseppina Covello, Sabine Krause, Magdalena Guzowska, Virginia Arechavala-Gomeza, Sven Even F. Borgos, Willeke M. C. van Roon-Mom, Taavi Lehto, Sandra Alves, Ronald A.M. Buijsen, Michela A. Denti, Aurélie Goyenvalle, Rob W.J. Collin, Irina Holodnuka, Lucia Echevarria

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2021, 13 (4), ⟨10.15252/emmm.202013243⟩
e13243
EMBO Molecular Medicine, 13
Digital.CSIC. Repositorio Institucional del CSIC
instname
EMBO Molecular Medicine, 13(4). WILEY
Hammond, S M, Aartsma-Rus, A, Alves, S, Borgos, S E, Buijsen, R A M, Collin, R W J, Covello, G, Denti, M A, Desviat, L R, Echevarría, L, Foged, C, Gaina, G, Garanto, A, Goyenvalle, A T, Guzowska, M, Holodnuka, I, Jones, D R, Krause, S, Lehto, T, Montolio, M, Van Roon-Mom, W & Arechavala-Gomeza, V 2021, ' Delivery of oligonucleotide-based therapeutics : challenges and opportunities ', EMBO Molecular Medicine, vol. 13, no. 4, e13243 . https://doi.org/10.15252/emmm.202013243
Biblos-e Archivo. Repositorio Institucional de la UAM
EMBO Molecular Medicine, 13, 4

Nucleic acid‐based therapeutics that regulate gene expression have been developed towards clinical use at a steady pace for several decades, but in recent years the field has been accelerating. To date, there are 11 marketed products based on antis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6de046d4014872f097c116dd271d0d7
https://doi.org/10.15252/emmm.202013243

Spurious regulatory connections dictate the expression-fitness landscape of translation factors

Autor: Darren J. Parker, Gene-Wei Li, Jean-Benoît Lalanne

Publikováno v: Molecular Systems Biology
Molecular Systems Biology, Vol 17, Iss 4, Pp n/a-n/a (2021)

During steady‐state cell growth, individual enzymatic fluxes can be directly inferred from growth rate by mass conservation, but the inverse problem remains unsolved. Perturbing the flux and expression of a single enzyme could have pleiotropic effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51046bcd6554619b92dfce8c511d7d3
https://pubmed.ncbi.nlm.nih.gov/33900014