Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Syntaxin binding protein 2"'
Akademický článek
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Autor:
Han Gyu Bae, Surendar Arumugam, Ashley L. St. John, Cheng Chun Wang, Weiping Han, Vinay Tergaonkar, Sangyong Jung, Hiu Yan Lam, Wanjin Hong
Publikováno v:
Science Advances
ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization.
ELKS1 is a protein with proposed roles in regulated exocytosis in neurons and nuclear factor κB (NF-κB) signaling in cance
ELKS1 is a protein with proposed roles in regulated exocytosis in neurons and nuclear factor κB (NF-κB) signaling in cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095d2ac7b28251d930cedc1c581074a6
https://doi.org/10.1126/sciadv.abb2497
https://doi.org/10.1126/sciadv.abb2497
Autor:
Hongxing Liu, Panxiang Cao, Xiangping Han, Fangyuan Jin, Yue-Hui Lin, Jiancheng Fang, Yang Zhang, Mangju Wang, Chun-Rong Tong, Wen Teng, Ping Zhu, Xue Chen, Fang Wang, Yuanli Xu
Publikováno v:
Oncology Letters
Certain patients with lymphoma may harbor mutations in perforin 1 (PRF1), unc-13 homolog D (UNC13D), syntaxin 11 (STX11), STXBP2 (syntaxin binding protein 2) or SH2 domain containing 1A (SH2D1A), which causes functional defects of cytotoxic lymphocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6356d3a8dd08b9d62450a9dc232f144
https://doi.org/10.3892/ol.2017.6898
https://doi.org/10.3892/ol.2017.6898
Autor:
Jack Bartram, Kerstin Amann, Carsten Posovszky, Michael Weintraub, Polina Stepensky, Ortraud Beringer, Persis Amrolia, Thomas F. E. Barth, Ansgar Schulz, Kai Lehmberg, Paul Walther, Udo zur Stadt, Manfred Hoenig, Alan D. Philips, Klaus-Michael Debatin
Publikováno v:
Pediatric Blood & Cancer. 60:1215-1222
Background Familial hemophagocytic lymphohistiocytosis (FHL) is a rare primary immune disorder defined by mutations in the syntaxin binding protein 2 (STXBP2) alias MUNC18-2. Despite defective immunity and a hyper-inflammatory state, clinical finding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b055ccf1490b84ce82df71324c3238ff
https://doi.org/10.1002/pbc.24475
https://doi.org/10.1002/pbc.24475
Autor:
Elsa M. Rodarte, Joo-Heon Yoon, Rustam Bagirzadeh, Zoulikha Azzegagh, Rupesh Nigam, James A. McNew, Binhui Ren, Brenton L. Scott, Youlia Petrova, Kyubo Kim, Michael J. Tuvim, Lucia Piccotti, Anurag Agrawal, Alejandra Gomez, Roberto Adachi, Christopher M. Evans, Burton F. Dickey, Vesa M. Olkkonen
Publikováno v:
Biochemical Journal
Airway mucin secretion and MC (mast cell) degranulation must be tightly controlled for homoeostasis of the lungs and immune system respectively. We found the exocytic protein Munc18b to be highly expressed in mouse airway epithelial cells and MCs, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a16dcc44d03feca71748d207a23da21
https://doi.org/10.1042/bj20120057
https://doi.org/10.1042/bj20120057
Publikováno v:
Clinical and Experimental Immunology. 163:271-283
Summary Familial haemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive disorder of immune dysregulation associated with uncontrolled T cell and macrophage activation and hypercytokinaemia. The incidence of FHL is 0·12/100·000 chil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0252e16cd226abda321922b1904844
https://doi.org/10.1111/j.1365-2249.2010.04302.x
https://doi.org/10.1111/j.1365-2249.2010.04302.x
Autor:
Brigitte Kasper, Udo zur Stadt, Florian Koch, Gudrun Nürnberg, Gritta Janka, Julia Pagel, Christian Becker, Wenke Seifert, Samantha Grieve, Stephan Ehl, Karin Beutel, Andrea Maul-Pavicic, Jan Rohr, Hans Christian Hennies, Julia Strauß, Gillian M. Griffiths
Publikováno v:
The American Journal of Human Genetics. 85:482-492
Rapid intracellular transport and secretion of cytotoxic granules through the immunological synapse requires a balanced interaction of several proteins. Disturbance of this highly regulated process underlies familial hemophagocytic lymphohistiocytosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6feb5400b7d99301a55424f7eae64765
https://doi.org/10.1016/j.ajhg.2009.09.005
https://doi.org/10.1016/j.ajhg.2009.09.005
Publikováno v:
ResearcherID
Familial Hemophagocytic Lymphohistiocytosis (FHL) is a rare autosomal recessive disorder. Diagnosis is established in presence of genetic mutation or positive family history in one of the siblings. Common genetic mutations associated with FHL are mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0aad1ed63ee48b1dbe8723d7bbb180
https://doi.org/10.1007/s13312-012-0094-5
https://doi.org/10.1007/s13312-012-0094-5
Autor:
Nicole Graf, Nick Evans
Publikováno v:
Pathology. 46:S33-S34
Hemophagocytic lymphohistiocytosis (HLH) is a disorder of immune regulation resulting in unregulated activation of T lymphocytes and macrophages, characterised by proliferation of benign appearing histiocytes with evidence of phagocytosis of hemopoie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba589eb7d4ce531e46025d9302077bd9
https://doi.org/10.1097/01.pat.0000454200.37323.65
https://doi.org/10.1097/01.pat.0000454200.37323.65
Akademický článek
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