Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Synphilin-1"'
Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 6, Pp 955-961 (2018)
Alzheimer's and Parkinson's diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for A
Externí odkaz:
https://doaj.org/article/c3a9a512f8954fea8c0dd3e371ee1dfa
Akademický článek
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Publikováno v:
Pharmacological Reports
Background Prolonged inflammation, oxidative stress, and protein aggregation are important factors contributing to Parkinson’s disease (PD) pathology. A known ROS generator, pesticide paraquat (PQ), was indicated as an environmental substance poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c6ec3b0f9902b82838e5a4df6604e3
https://doi.org/10.1007/s43440-021-00340-1
https://doi.org/10.1007/s43440-021-00340-1
Autor:
Alexandre Denadai-Souza, Adriana Oliveira Manfiolli, L. M. Yshii, Marcelo D. Gomes, Paula Fernanda Kinoshita, Cristoforo Scavone
Publikováno v:
IBRO Reports, Vol 9, Iss, Pp 218-223 (2020)
IBRO Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
IBRO Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Highlights • TRAF6 binds to both WT and the mutant form A30 P asyn in SH-SY5Y cell model. • The activation of NF-κB leads to changes in cytokines levels induced by TRAF6 - WT asyn interaction decreasing cell viability. • The interaction betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22abc28f919a4be7871467c2b5d61b34
http://www.sciencedirect.com/science/article/pii/S2451830120300388
http://www.sciencedirect.com/science/article/pii/S2451830120300388
Autor:
Rina Bandopadhyay, Ann E. Kingsbury, Miratul M. Muqit, Kirsten Harvey, Andrew R. Reid, Linda Kilford, Simone Engelender, Michael G. Schlossmacher, Nicholas W. Wood, David S. Latchman, Robert J. Harvey, Andrew J. Lees
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 401-411 (2005)
Lewy bodies (LBs) are the characteristic inclusions of Parkinson's disease brain but the mechanism responsible for their formation is obscure. Lewy bodies (LBs) are composed of a number of proteins of which alpha-synuclein (α-SYN) is a major constit
Externí odkaz:
https://doaj.org/article/6f0ed25c8e0f4630918b13e818439830
Autor:
Tianxia Li, Timothy H. Moran, Gongbo Guo, Rui Ma, Xiaobo Wang, Bo Ning, Jingnan Liu, Wanli W. Smith
Publikováno v:
J Cell Sci
Expression of synphilin-1 in neurons induces hyperphagia and obesity in a Drosophila model. However, the molecular pathways underlying synphilin-1-linked obesity remain unclear. Here, Drosophila models and genetic tools were used to study the synphil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4dad805b34a319486be1d191ab38e1
https://europepmc.org/articles/PMC7875497/
https://europepmc.org/articles/PMC7875497/
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1677, p 1677 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences
Volume 22
Issue 4
Synphilin-1 has previously been identified as an interaction partner of α-Synuclein (αSyn), a primary constituent of neurodegenerative disease-linked Lewy bodies. In this study, the repercussions of a disrupted glyoxalase system and aldose reductas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c694ad8800b2457b1c6e711ae7c60c94
https://www.mdpi.com/1422-0067/22/4/1677
https://www.mdpi.com/1422-0067/22/4/1677
Akademický článek
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Publikováno v:
Journal of Functional Foods, Vol 29, Iss, Pp 104-114 (2017)
We investigated the neuroprotective effects of orobol derivatives and ethanol extracts from Cudrania tricuspidata fruits. Among the nine isolates from a 50% ethanol extract from Cudrania tricuspidata fruits (CTE50), orobol (OB), 6-prenylorobol (POB),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94778ac8f911bd723535ea6250019141
http://www.sciencedirect.com/science/article/pii/S1756464616304054
http://www.sciencedirect.com/science/article/pii/S1756464616304054