Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)

Autor: Kirsten Jenkins, Teodora Mateeva, István Szabó, Andre Melnik, Paola Picotti, Attila Csikász-Nagy, Edina Rosta

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1032-1042 (2020)

Parkinson’s disease (PD), Alzheimer’s disease (AD) and Amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases hallmarked by the formation of toxic protein aggregates. However, targeting these aggregates therapeutically have thus far s

Externí odkaz: https://doaj.org/article/7e2ec4eee7964fa3bd2acef156c3f96c

Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)

Autor: Paola Picotti, Kirsten Jenkins, István Szabó, Andre Melnik, Edina Rosta, Teodora Mateeva, Attila Csikász-Nagy

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1032-1042 (2020)
Mateeva, T, Rosta, E, Csikasz-Nagy, A & Jenkins, K 2020, ' Combining data integration and molecular dynamics for target identification in α-synuclein-aggregating neurodegenerative diseases : Structural insights on Synaptojanin-1 (Synj1) ', Journal of Computational and Structural Biotechnology, vol. 18, pp. 1032-1042 . https://doi.org/10.1016/j.csbj.2020.04.010
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, 18

Parkinson's disease (PD), Alzheimer's disease (AD) and Amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases hallmarked by the formation of toxic protein aggregates. However, targeting these aggregates therapeutically have thus far shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0dafbaad0dfce618523c7e19ac96eda
http://www.sciencedirect.com/science/article/pii/S2001037020300428

Polyunsaturated fatty acid‐containing phosphatidic acid interacts with synaptojanin‐1 and enhances its phosphoinositide D‐4‐phosphatase activity

Autor: Fumio Sakane, Fumi Hoshino

Publikováno v: The FASEB Journal. 35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c1fa7dd84c834dd079c374635e7cccd
https://doi.org/10.1096/fasebj.2021.35.s1.01910

Mini-review: Synaptojanin 1 and its implications in membrane trafficking

Autor: Hassaam Choudhry, Ping-Yue Pan, Meha Aggarwal

Publikováno v: Neuroscience letters

This mini-review aims to summarize a growing body of literature on synaptojanin 1 (Synj1), a phosphoinositide phosphatase that was initially known to have a prominent role in synaptic vesicle recycling. Synj1 is coded by the SYNJ1 gene, whose mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9bab30cdce904225990137fd425d73
https://doi.org/10.1016/j.neulet.2021.136288

Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen

Autor: Caterina Collodet, Simon F. Spiegl, Saifeldin N. Shehata, Stephan Geley, Kei Sakamoto, David Sumpton, Maria Deak

Publikováno v: Cellular signalling. 59

PCTAIRE-1 (also known as cyclin-dependent protein kinase (CDK) 16), is a Ser/Thr kinase that has been implicated in many cellular processes, including cell cycle, spermatogenesis, neurite outgrowth, and vesicle trafficking. Most recently, it has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f75f0075063f231c8b95f35df81cb5
https://pubmed.ncbi.nlm.nih.gov/30880224