Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)

Autor: Kirsten Jenkins, Teodora Mateeva, István Szabó, Andre Melnik, Paola Picotti, Attila Csikász-Nagy, Edina Rosta

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1032-1042 (2020)

Parkinson’s disease (PD), Alzheimer’s disease (AD) and Amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases hallmarked by the formation of toxic protein aggregates. However, targeting these aggregates therapeutically have thus far s

Externí odkaz: https://doaj.org/article/7e2ec4eee7964fa3bd2acef156c3f96c

Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)

Autor: Jenkins, Kirsten, Mateeva, Teodora, Szabó, István, Melnik, Andre, Picotti, Paola, Csikász-Nagy, Attila, Rosta, Edina

Publikováno v: In Computational and Structural Biotechnology Journal 2020 18:1032-1042

Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons.

Autor: Rafiq NM; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Department of Cell biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair. Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Fujise K; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Department of Cell biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair. Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Rosenfeld MS; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Department of Cell biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair. Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Xu P; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Department of Cell biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair. Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Wu Y; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Department of Cell biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair. Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., De Camilli P; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Department of Cell biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair. Yale University School of Medicine, New Haven, Connecticut 06510, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 13. Date of Electronic Publication: 2023 Oct 13.

The SAC1 phosphatase domain of synaptojanin‐1 is activated by interacting with polyunsaturated fatty acid‐containing phosphatidic acids

Autor: Fumio Sakane, Fumi Hoshino

Publikováno v: FEBS Letters. 595:2479-2492

Although there are many phosphatidic acid (PA) molecular species based on its fatty acyl compositions, their interacting partners have been poorly investigated. Here, we identified synaptojanin-1 (SYNJ1), a Parkinson's disease-related protein that is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c3a6e084deec275ff20a6ea44f1780
https://doi.org/10.1002/1873-3468.14177

Polyunsaturated fatty acid‐containing phosphatidic acid interacts with synaptojanin‐1 and enhances its phosphoinositide D‐4‐phosphatase activity

Autor: Fumio Sakane, Fumi Hoshino

Publikováno v: The FASEB Journal. 35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c1fa7dd84c834dd079c374635e7cccd
https://doi.org/10.1096/fasebj.2021.35.s1.01910