α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?

Autor: Lennart Brodin, Dragomir Milovanovic, Silvio O. Rizzoli, Oleg Shupliakov

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

The protein α-synuclein, which is well-known for its links to Parkinson’s Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence

Externí odkaz: https://doaj.org/article/033c546321004a0d837e1a780e07b9d3

Synuclein Regulates Synaptic Vesicle Clustering and Docking at a Vertebrate Synapse

Autor: Kaitlyn E. Fouke, M. Elizabeth Wegman, Sarah A. Weber, Emily B. Brady, Cristina Román-Vendrell, Jennifer R. Morgan

Publikováno v: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Neurotransmission relies critically on the exocytotic release of neurotransmitters from small synaptic vesicles (SVs) at the active zone. Therefore, it is essential for neurons to maintain an adequate pool of SVs clustered at synapses in order to sus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266e1144cf9a32d1c4d9909018fd4510

SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering

Autor: Ka Wan Li, Fatima Farzana, Frank Koopmans, August B. Smit, Jessie W. Brunner, Silvia Oldani, Matthijs Verhage, Marinka Brouwer, Ruud F. Toonen, Ning Chen, Jan R.T. van Weering

Publikováno v: Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R T, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289 . https://doi.org/10.15252/embj.2018101289
EMBO Journal, 38(17):e101289, 1-20. Nature Publishing Group
EMBO Journal, 38(17):e101289. Wiley-Blackwell
Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289, pp. 1-20 . https://doi.org/10.15252/embj.2018101289
The EMBO Journal

Synapse development requires spatiotemporally regulated recruitment of synaptic proteins. In this study, we describe a novel presynaptic mechanism of cis‐regulated oligomerization of adhesion molecules that controls synaptogenesis. We identified sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccd74ba8c64f4a684dea731fcb80231
https://doi.org/10.15252/embj.2018101289

Protocol for Quantitative Analysis of Synaptic Vesicle Clustering in Axons of Cultured Neurons

Autor: Se-Young Choi, Kyung Ah Han, Jaewon Ko, Ji Won Um

Publikováno v: STAR Protocols
STAR Protocols, Vol 1, Iss 2, Pp 100095-(2020)

Summary Clustering of synaptic vesicles along the neuronal axons is a critical mechanism underpinning proper synaptic transmission. Here, we provide a detailed protocol for analyzing the distribution of synaptic vesicles in presynaptic boutons of cul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5440507fab4e6916e3a79fa4e976d800
https://pubmed.ncbi.nlm.nih.gov/33111124

Differential Properties of the Synaptogenic Activities of the Neurexin Ligands Neuroligin1 and LRRTM2

Autor: Kurt Gottmann, Sushma Dagar

Publikováno v: Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience

Synaptic cell adhesion molecules are well established to exhibit synaptogenic activity when overexpressed in target cells, indicating that they are involved in formation and functional maturation of synapses. The postsynaptic adhesion proteins Neurol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fa7049dfe20843624a72124d0891ad
https://www.frontiersin.org/article/10.3389/fnmol.2019.00269/full