Zobrazeno 1 - 10
of 2 651
pro vyhledávání: '"Synaptic scaling"'
Autor:
Kevin P. Koster, Zach Fyke, Thu T. A. Nguyen, Amanda Niqula, Lorena Y. Noriega-González, Kevin M. Woolfrey, Mark L. Dell’Acqua, Stephanie M. Cologna, Akira Yoshii
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 16 (2024)
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), is associat
Externí odkaz:
https://doaj.org/article/e3a613aeb95d49d588cfd343ac8d71e8
Autor:
Simón(e) D. Sun, Daniel Levenstein, Boxing Li, Nataniel Mandelberg, Nicolas Chenouard, Benjamin S. Suutari, Sandrine Sanchez, Guoling Tian, John Rinzel, György Buzsáki, Richard W. Tsien
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113839- (2024)
Summary: Homeostatic regulation of synapses is vital for nervous system function and key to understanding a range of neurological conditions. Synaptic homeostasis is proposed to operate over hours to counteract the destabilizing influence of long-ter
Externí odkaz:
https://doaj.org/article/5dbc5cec77d4460ab8a9a6266f3ea3b3
Publikováno v:
Neuromorphic Computing and Engineering, Vol 4, Iss 4, p 044003 (2024)
Biologically plausible spiking neural network models of sensory cortices can be instrumental in understanding and validating their principles of computation. Models based on Cortical Computational Primitives (CCPs), such as Hebbian plasticity and Win
Externí odkaz:
https://doaj.org/article/dd0a668e490e4e04b8d8f9a42701e031
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 1, Pp 20-24 (2022)
Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic changes in the network activity. This type of plasticity is essential for the maintenance of brain circuits and is involved in the regul
Externí odkaz:
https://doaj.org/article/75485d05db13478eb16ecebef2210b43
Akademický článek
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A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling
Autor:
Chi-Hong Wu, Vedakumar Tatavarty, Pierre M Jean Beltran, Andrea A Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A Carr, Jeffrey R Cottrell, Gina G Turrigiano
Publikováno v:
eLife, Vol 11 (2022)
Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of post-translational modifications in this process has not been systematically studied. Using deep-scale quantitative analysi
Externí odkaz:
https://doaj.org/article/62dee5cecd974444b9a59db1da6ab44d
Autor:
Thiago C. Moulin, Helgi B. Schiöth
Publikováno v:
Behavioral and Brain Functions, Vol 16, Iss 1, Pp 1-4 (2020)
Abstract Glutamatergic AMPA and NMDA receptors in the ventral tegmental area (VTA) are central for cocaine first exposure and posterior craving maintenance. However, the exact rules that coordinate the synaptic dynamics of these receptors in dopamine
Externí odkaz:
https://doaj.org/article/7ed39aad40834d7cac09f3f047fb1783
Autor:
Henry B. C. Taylor, Alexander F. Jeans
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Homeostatic synaptic plasticity (HSP) regulates synaptic strength both pre- and postsynaptically to ensure stability and efficient information transfer in neural networks. A number of neurological diseases have been associated with deficits in HSP, p
Externí odkaz:
https://doaj.org/article/dc65afad0e864488b8517568800a9a05
Akademický článek
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Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109918- (2021)
Summary: Ketamine is a noncompetitive glutamatergic N-methyl-d-aspartate receptor (NMDAR) antagonist that exerts rapid antidepressant effects. Preclinical studies identify eukaryotic elongation factor 2 kinase (eEF2K) signaling as essential for the r
Externí odkaz:
https://doaj.org/article/6dd69221221e448c8ccdfbb132cd2ff5