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The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast synaptic vesicle fusion

Autor: Chad Paul Grabner, Tobias Moser

Publikováno v: eLife, Vol 10 (2021)

Rod photoreceptors (PRs) use ribbon synapses to transmit visual information. To signal ‘no light detected’ they release glutamate continually to activate post-synaptic receptors. When light is detected glutamate release pauses. How a rod’s indi

Externí odkaz: https://doaj.org/article/425439e748cf4eea97d9abb585b68a7b

Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels

Autor: Caixia Lv, William J. Stewart, Otar Akanyeti, Courtney Frederick, Jie Zhu, Joseph Santos-Sacchi, Lavinia Sheets, James C. Liao, David Zenisek

Publikováno v: Cell Reports, Vol 15, Iss 12, Pp 2784-2795 (2016)

Synaptic ribbons are structures made largely of the protein Ribeye that hold synaptic vesicles near release sites in non-spiking cells in some sensory systems. Here, we introduce frameshift mutations in the two zebrafish genes encoding for Ribeye and

Externí odkaz: https://doaj.org/article/7b9a780aebe04ad3be72bea85cc0795c

Ciliary Proteins Repurposed by the Synaptic Ribbon: Trafficking Myristoylated Proteins at Rod Photoreceptor Synapses

Autor: Schmitz, Shweta Suiwal, Mayur Dembla, Karin Schwarz, Rashmi Katiyar, Martin Jung, Yvonne Carius, Stephan Maxeiner, Marcel A. Lauterbach, C. Roy D. Lancaster, Frank

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7135

The Unc119 protein mediates transport of myristoylated proteins to the photoreceptor outer segment, a specialized primary cilium. This transport activity is regulated by the GTPase Arl3 as well as by Arl13b and Rp2 that control Arl3 activation/inacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::149d1088b5e10dd85636115d7edd782f

Early Changes in Exo- and Endocytosis in the EAE Mouse Model of Multiple Sclerosis Correlate with Decreased Synaptic Ribbon Size and Reduced Ribbon-Associated Vesicle Pools in Rod Photoreceptor Synapses

Autor: Karin Schwarz, Ekta Dembla, Mayur Dembla, Ajay Kesharwani, Frank Schmitz

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10789, p 10789 (2021)

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system that finally leads to demyelination. Demyelinating optic neuritis is a frequent symptom in MS. Recent studies also revealed synapse dysfunctions in MS patients and MS mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b3d43eb8bdf2a28caea1b26263e421
https://pubmed.ncbi.nlm.nih.gov/34639129