Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Synapses / drug effects"'
Autor:
Charles K. Meshul, Lise Verbruggen, Eduard Bentea, Madeline J Churchill, Lauren Deneyer, Rebecca L. Hood, Ann Massie, Cynthia Moore
Publikováno v:
Brain Research Bulletin. 130:257-267
In Parkinson's disease, striatal dopamine depletion leads to plastic changes at excitatory corticostriatal and thalamostriatal synapses. The functional consequences of these responses on the expression of behavioral deficits are incompletely understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26bcb25b19280a2e924c3895ef00525
https://doi.org/10.1016/j.brainresbull.2017.02.005
https://doi.org/10.1016/j.brainresbull.2017.02.005
Autor:
Joana F. Henriques, Renata L. Alves, Ana Magalhães, Teresa Summavielle, Teresa Canedo, Camila C. Portugal, Cátia M. Silva, João B. Relvas, Renato Socodato, Tiago Almeida, Joana Tedim-Moreira
Alcohol abuse adversely affects the lives of millions of people worldwide. Deficits in synaptic transmission and in microglial function are commonly found in human alcohol abusers and in animal models of alcohol intoxication. Here, we found that a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5323d1d38dd85484e38fe3dc3daa066
https://hdl.handle.net/10216/140511
https://hdl.handle.net/10216/140511
Autor:
Josef Bischofberger, Nicolas Toni, Stefanie Heigele, Charlotte Schmidt-Salzmann, Sébastien Sultan, Liyi Li
Publikováno v:
eLife, Vol 6 (2017)
eLife, vol. 6, pp. e23612
eLife
eLife, vol. 6, pp. e23612
eLife
In adult neurogenesis young neurons connect to the existing network via formation of thousands of new synapses. At early developmental stages, glutamatergic synapses are sparse, immature and functionally 'silent', expressing mainly NMDA receptors. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c8ece4563131045f7de155c1f8b2da
https://elifesciences.org/articles/23612
https://elifesciences.org/articles/23612
Autor:
Péter Barthó, Zita Rovó, Anita Lüthi, Csaba Dávid, Chiara Pellegrini, Andrea Slézia, Simone Astori, Balázs Hangya, Sandro Lecci, Ferenc Mátyás, László Acsády
Publikováno v:
JOURNAL OF NEUROSCIENCE
Journal of Neuroscience, vol. 34, no. 21, pp. 7137-7147
Journal of Neuroscience, vol. 34, no. 21, pp. 7137-7147
GABA-A receptors (GABA-ARs) are typically expressed at synaptic or nonsynaptic sites mediating phasic and tonic inhibition, respectively. These two forms of inhibition conjointly control various network oscillations. To disentangle their roles in tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b51bfcc2d767160df3b874bf2589fc
Autor:
Judith Blanz, Paul Saftig, Stijn Stroobants, Ann Van der Jeugd, Rudi D'Hooge, Markus Damme, Ben Vermaercke, Claes Andersson, Jens Fogh
Publikováno v:
Neurobiology of Disease, Vol 106, Iss, Pp 255-268 (2017)
Alpha-mannosidosis is a glycoproteinosis caused by deficiency of lysosomal acid alpha-mannosidase (LAMAN), which markedly affects neurons of the central nervous system (CNS), and causes pathognomonic intellectual dysfunction in the clinical condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efa1f42341ae0f754812c573cc09580
https://doi.org/10.1016/j.nbd.2017.07.013
https://doi.org/10.1016/j.nbd.2017.07.013
Autor:
Yannis Dalezios, Francesco Ferraguti, Ryuichi Shigemoto, Marco Capogna, Peter Somogyi, Naoki Kogo
Publikováno v:
Kogo, N, Dalezios, Y, Capogna, M, Ferraguti, F, Shigemoto, R & Somogyi, P 2004, ' Depression of GABAergic input to identified hippocampal neurons by group III metabotropic glutamate receptors in the rat ', The European journal of neuroscience, vol. 19, no. 10, pp. 2727-40 . https://doi.org/10.1111/j.0953-816X.2004.03394.x
The release of GABA in synapses is modulated by presynaptic metabotropic glutamate receptors (mGluRs). We tested whether GABA release to identified hippocampal neurons is influenced by group III mGluR activation using the agonist L-(+)-2-amino-4-phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85919f3a95f9d44365dd61e823b151ac
https://ora.ox.ac.uk/objects/uuid:456fde59-fa6c-4f47-9625-3967a8b29607
https://ora.ox.ac.uk/objects/uuid:456fde59-fa6c-4f47-9625-3967a8b29607
Publikováno v:
Nature neuroscience
Nature Neuroscience, Vol. 14, No 11 (2011) pp. 1439-46
Nature Neuroscience, Vol. 14, No 11 (2011) pp. 1439-46
Maternal exposure to cocaine may perturb fetal development and affect synaptic maturation in the offspring. However, the molecular mechanism underlying such changes remains elusive. We focused on the postnatal maturation of glutamatergic transmission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0994697f1088c5d1dfbf944ce6e30bf5
https://doi.org/10.1038/nn.2930
https://doi.org/10.1038/nn.2930
Autor:
Dirk Fasshauer, Tobias H. Kloepper, Pawel Burkhardt, Christian Stegmann, Cordelia Imig, Markus C. Wahl, Frederique Varoqueaux, Benjamin H. Cooper
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 37, pp. 15264-15269
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
SNARE protein-driven secretion of neurotransmitters from synaptic vesicles is at the center of neuronal communication. In the absence of the cytosolic protein Munc18-1, synaptic secretion comes to a halt. Although it is believed that Munc18-1 orchest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dced20bbb212ca6317870bd3c3bbbb
https://doi.org/10.1073/pnas.1106189108
https://doi.org/10.1073/pnas.1106189108
Autor:
Dominique Muller, Mathias De Roo, Laszlo Vutskits, Irina Nikonenko, Adrian Briner, Alexandre Dayer
Publikováno v:
Anesthesiology
Anesthesiology, Vol. 115, No 2 (2011) pp. 282-93
Anesthesiology, Vol. 115, No 2 (2011) pp. 282-93
Background Recent observations demonstrate that anesthetics rapidly impair synaptogenesis during neuronal circuitry development. Whether these effects are lasting and depend on the developmental stage at which these drugs are administered remains, ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721082c245b61442657a40f7ed2a793a
https://doi.org/10.1097/aln.0b013e318221fbbd
https://doi.org/10.1097/aln.0b013e318221fbbd
Autor:
Dominique Muller, Laszlo Vutskits, Adrian Briner, Mathias De Roo, Walid Habre, Alexandre Dayer
Publikováno v:
Anesthesiology
Anesthesiology, Vol. 112, No 3 (2010) pp. 546-556
Anesthesiology, Vol. 112, No 3 (2010) pp. 546-556
Background Recent experimental observations suggest that, in addition to induce neuroapoptosis, anesthetics can also interfere with synaptogenesis during brain development. The aim of this study was to pursue this issue by evaluating the exposure tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ce26a828e798c3856486bb6f70d61d
https://doi.org/10.1097/aln.0b013e3181cd7942
https://doi.org/10.1097/aln.0b013e3181cd7942