Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Synapses/metabolism"'
Autor:
Ka Wan Li, Fatima Farzana, Frank Koopmans, August B. Smit, Jessie W. Brunner, Silvia Oldani, Matthijs Verhage, Marinka Brouwer, Ruud F. Toonen, Ning Chen, Jan R.T. van Weering
Publikováno v:
Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R T, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289 . https://doi.org/10.15252/embj.2018101289
EMBO Journal, 38(17):e101289, 1-20. Nature Publishing Group
EMBO Journal, 38(17):e101289. Wiley-Blackwell
Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289, pp. 1-20 . https://doi.org/10.15252/embj.2018101289
The EMBO Journal
EMBO Journal, 38(17):e101289, 1-20. Nature Publishing Group
EMBO Journal, 38(17):e101289. Wiley-Blackwell
Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289, pp. 1-20 . https://doi.org/10.15252/embj.2018101289
The EMBO Journal
Synapse development requires spatiotemporally regulated recruitment of synaptic proteins. In this study, we describe a novel presynaptic mechanism of cis‐regulated oligomerization of adhesion molecules that controls synaptogenesis. We identified sy
Autor:
Bercier, Valérie, Hubbard, Jeffrey M., Fidelin, Kevin, Duroure, Karine, Auer, Thomas O., Revenu, Céline, Wyart, Claire, Del Bene, Filippo
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-22 (2019)
Molecular Neurodegeneration
Molecular Neurodegeneration, BioMed Central, 2019, 14 (1), pp.27. ⟨10.1186/s13024-019-0327-3⟩
Molecular Neurodegeneration, 2019, 14 (1), pp.27. ⟨10.1186/s13024-019-0327-3⟩
Molecular neurodegeneration, vol. 14, no. 1, pp. 27
Molecular Neurodegeneration
Molecular Neurodegeneration, BioMed Central, 2019, 14 (1), pp.27. ⟨10.1186/s13024-019-0327-3⟩
Molecular Neurodegeneration, 2019, 14 (1), pp.27. ⟨10.1186/s13024-019-0327-3⟩
Molecular neurodegeneration, vol. 14, no. 1, pp. 27
Background Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein. Reduced levels of DCTN1 mRNA and protein have been found in sporadic amyotrophic lateral sclerosis (ALS) patient
Autor:
Ana Magalhães, Teresa Canedo, Renata L. Alves, Ana M. F. P. Silva, Sandra H. Vaz, Tiago Almeida, Renato Socodato, Cátia M. Silva, Ana M. Sebastião, João B. Relvas, António F. Ambrósio, Cord Brakebusch, Joana F. Henriques, Roberto Paes-de-Carvalho, Teresa Summavielle, Filipa I. Baptista, João P. Magalhães, Artur Rodrigues, Camila C. Portugal, Vanessa Coelho-Santos
Publikováno v:
Socodato, R, Portugal, C C, Canedo, T, Rodrigues, A, Almeida, T O, Henriques, J F, Vaz, S H, Magalhães, J, Silva, C M, Baptista, F I, Alves, R L, Coelho-Santos, V, Silva, A P, Paes-de-Carvalho, R, Magalhães, A, Brakebusch, C, Sebastião, A M, Summavielle, T, Ambrósio, A F & Relvas, J B 2020, ' Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration ', Cell Reports, vol. 31, no. 12, 107796, pp. 1-29 . https://doi.org/10.1016/j.celrep.2020.107796
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Reports
© 2020 The Author(s). Creative Commons Attribution (CC BY 4.0)
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb571fceba1952acaecbe0bcbe6bc791
https://curis.ku.dk/portal/da/publications/microglia-dysfunction-caused-by-the-loss-of-rhoa-disrupts-neuronal-physiology-and-leads-to-neurodegeneration(af46c589-efa7-462d-8150-2a9c7d52e48a).html
https://curis.ku.dk/portal/da/publications/microglia-dysfunction-caused-by-the-loss-of-rhoa-disrupts-neuronal-physiology-and-leads-to-neurodegeneration(af46c589-efa7-462d-8150-2a9c7d52e48a).html
Autor:
H, Chang, N, Hoshina, C, Zhang, Y, Ma, H, Cao, Y, Wang, D-d, Wu, S E, Bergen, M, Landén, C M, Hultman, M, Preisig, Z, Kutalik, E, Castelao, M, Grigoroiu-Serbanescu, A J, Forstner, J, Strohmaier, J, Hecker, T G, Schulze, B, Müller-Myhsok, A, Reif, P B, Mitchell, N G, Martin, P R, Schofield, S, Cichon, M M, Nöthen, H, Walter, S, Erk, A, Heinz, N, Amin, C M, van Duijn, A, Meyer-Lindenberg, H, Tost, X, Xiao, T, Yamamoto, M, Rietschel, M, Li, Louise, Frisén, Catharina, Lavebratt, Lena, Backlund, Martin, Schalling, Urban, Ösby, Thomas W, Mühleisen, Markus, Leber, Franziska, Degenhardt, Jens, Treutlein, Manuel, Mattheisen, Anna, Maaser, Sandra, Meier, Stefan, Herms, Per, Hoffmann, André, Lacour, Stephanie H, Witt, Fabian, Streit, Susanne, Lucae, Wolfgang, Maier, Markus, Schwarz, Helmut, Vedder, Jutta, Kammerer-Ciernioch, Andrea, Pfennig, Michael, Bauer, Martin, Hautzinger, Adam, Wright, Janice M, Fullerton, Grant W, Montgomery, Sarah E, Medland, Scott D, Gordon, Tim, Becker, Johannes, Schumacher, Peter, Propping, Group, The Swedish Bipolar Study, D. S. Bipolar Consortium, Moo
Publikováno v:
Molecular psychiatry, vol. 23, no. 2, pp. 400-412
Molecular Psychiatry, 23(2), 400-412. Nature Publishing Group
Molecular Psychiatry
MOLECULAR PSYCHIATRY
Molecular psychiatry 23, 400–412 (2018). doi:10.1038/mp.2016.231
Molecular Psychiatry, 23(2), 400-412. Nature Publishing Group
Molecular Psychiatry
MOLECULAR PSYCHIATRY
Molecular psychiatry 23, 400–412 (2018). doi:10.1038/mp.2016.231
Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scal
Publikováno v:
Cellular and Molecular Life Sciences. 73(10):2053-2077
Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory facto
Publikováno v:
Saiepour, M H, Chakravarthy, S, Min, R & Levelt, C N 2015, ' Competition and Homeostasis of Excitatory and Inhibitory Connectivity in the Adult Mouse Visual Cortex ', Cerebral Cortex, vol. 25, no. 10, pp. 3713-22 . https://doi.org/10.1093/cercor/bhu245
Cerebral Cortex, 25(10), 3713-22. Oxford University press
Cerebral Cortex, 25(10), 3713-22. Oxford University Press
Cerebral Cortex (New York, NY)
Cerebral Cortex, 25(10), 3713-22. Oxford University press
Cerebral Cortex, 25(10), 3713-22. Oxford University Press
Cerebral Cortex (New York, NY)
During cortical development, synaptic competition regulates the formation and adjustment of neuronal connectivity. It is unknown whether synaptic competition remains active in the adult brain and how inhibitory neurons participate in this process. Us
Autor:
Elias Gebara, Christine Fülling, Frédéric Cassé, Samia Habbas, Marine Krzisch, Andrea Volterra, Laura Jabinet, Nicolas Toni, Jan Armida, Jean-Pierre Hornung
Publikováno v:
Cerebral cortex, vol. 27, no. 8, pp. 4048-4059
Cerebral cortex (New York N.Y. : 1991)
Europe PubMed Central
Cerebral cortex (New York N.Y. : 1991)
Europe PubMed Central
Postnatal hippocampal neurogenesis induces network remodeling and may participate to mechanisms of learning. In turn, the maturation and survival of newborn neurons is regulated by their activity. Here, we tested the effect of a cell-autonomous overe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84c4355ee8ee9768958230bf7f72fed
https://serval.unil.ch/notice/serval:BIB_A053A4128CE0
https://serval.unil.ch/notice/serval:BIB_A053A4128CE0
Autor:
Geert Baggerman, Jeroen Aerts, Kurt Boonen, Dirk Valkenborg, Annelies Laeremans, Laurens Minerva, Rudi D'Hooge, Budamgunta Harshavardhan, Lutgarde Arckens
Publikováno v:
Biochimica et biophysica acta : proteins and proteomics
The Morris water maze (MWM) spatial learning task has been demonstrated to involve a cognitive switch of action control to serve the transition from an early towards a late learning phase. However, the molecular mechanisms governing this switch are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5d3b298bab16d6e0e67e2c494d22b9
http://linkinghub.elsevier.com/retrieve/pii/S1570-9639(16)30218-7
http://linkinghub.elsevier.com/retrieve/pii/S1570-9639(16)30218-7
Autor:
Matthew T. Valley, Guo Li Ming, Gerald J. Sun, Hermann Riecke, Shirin Sharafi, Pierre-Marie Lledo, Martin T. Wiechert, Wayne Adams, Kurt A. Sailor, James C. Dennis, Hongjun Song
Publikováno v:
Neuron
Neuron, Elsevier, 2016, 91 (2), pp.384-396. ⟨10.1016/j.neuron.2016.06.004⟩
Neuron, 2016, 91 (2), pp.384-396. ⟨10.1016/j.neuron.2016.06.004⟩
Neuron, Elsevier, 2016, 91 (2), pp.384-396. ⟨10.1016/j.neuron.2016.06.004⟩
Neuron, 2016, 91 (2), pp.384-396. ⟨10.1016/j.neuron.2016.06.004⟩
International audience; In the mammalian brain, the anatomical structure of neural circuits changes little during adulthood. As a result, adult learning and memory are thought to result from specific changes in synaptic strength. A possible exception
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8444b98e009eb8f26f10f658d25965bd
https://europepmc.org/articles/PMC5476833/
https://europepmc.org/articles/PMC5476833/
Autor:
Elias Gebara, Ruadhan O’Laoi, Jacqueline Kocher-Braissant, Nicolas Toni, Irene Sánchez-Pascual, Imane El M’Ghari, Eric A. Bushong, Mark H. Ellisman, Jonathan Moss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 18, pp. E2536-45
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 18
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 18
Adult hippocampal neurogenesis relies on the activation of neural stem cells in the dentate gyrus, their division, and differentiation of their progeny into mature granule neurons. The complex morphology of radial glia-like (RGL) stem cells suggests