Zobrazeno 1 - 10
of 507
pro vyhledávání: '"Synapse maturation"'
Akademický článek
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Autor:
Steffen, David M.
Cell adhesion molecules (CAMs) are key players in the formation of neural circuits during development. The Gamma-Protocadherins (Gamma-Pcdhs), a family of 22 CAMs encoded by the Pcdhg gene cluster, are known to play important roles in dendrite arbori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::974b554c8f8356715ccd7a82b5935f6b
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Deficiency of otoferlin causes profound prelingual deafness in humans and animal models. Here, we closely analyzed developmental deficits and degenerative mechanisms in Otof knock-out (Otof–/–) mice over the course of 48 weeks. We found otoferlin
Externí odkaz:
https://doaj.org/article/b7cc15a3a0094c49896df0a707d4e557
Publikováno v:
Neural Development, Vol 13, Iss 1, Pp 1-17 (2018)
Abstract Inhibition in the central nervous systems (CNS) is mediated by two neurotransmitters: gamma-aminobutyric acid (GABA) and glycine. Inhibitory synapses are generally GABAergic or glycinergic, although there are synapses that co-release both ne
Externí odkaz:
https://doaj.org/article/b8e6f32284f64d648527c3c0f222665d
Autor:
Michael J. Molumby, Rachel M. Anderson, Dillan J. Newbold, Norah K. Koblesky, Andrew M. Garrett, Dietmar Schreiner, Jason J. Radley, Joshua A. Weiner
Publikováno v:
Cell Reports, Vol 18, Iss 11, Pp 2702-2714 (2017)
The 22 γ-Protocadherin (γ-Pcdh) cell adhesion molecules are critical for the elaboration of complex dendritic arbors in the cerebral cortex. Here, we provide evidence that the γ-Pcdhs negatively regulate synapse development by inhibiting the posts
Externí odkaz:
https://doaj.org/article/efd28dc1daf948f7a9c622d38a4988a0
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The amygdala, and more precisely its lateral nucleus, is thought to attribute emotional valence to external stimuli by generating long-term plasticity changes at long-range projections to principal cells. Aversive experience has also been shown to mo
Externí odkaz:
https://doaj.org/article/13120edcf6854241bb92f2564ab7f047
Autor:
Roos Anouk Voorn, Christian Vogl
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8758 (2020)
In the mammalian cochlea, specialized ribbon-type synapses between sensory inner hair cells (IHCs) and postsynaptic spiral ganglion neurons ensure the temporal precision and indefatigability of synaptic sound encoding. These high-through-put synapses
Externí odkaz:
https://doaj.org/article/a3cc317faccc410da53433e409b59a1f
Akademický článek
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Autor:
Shunqi Wang, Xinsheng Lai, Tian Zhou, Peng Chen, Dong Lin, Baoming Li, Bing-Xing Pan, Erkang Fei, Ziyang Liu, Huifeng Jiao, Song Lu, Suqi Zou, Jianghong Liu, Qian Zhang, Li Zhu
Publikováno v:
The Journal of Neuroscience
Mutations in some cell adhesion molecules (CAMs) cause abnormal synapse formation and maturation, and serve as one of the potential mechanisms of autism spectrum disorders (ASDs). Recently,DSCAM(Down syndrome cell adhesion molecule) was found to be a
Akademický článek
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