Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Symposium: Molecular Genetics in Sarcoma"'
Publikováno v:
Clinical Orthopaedics and Related Research. 466:2060-2070
There is a critical need to identify markers that can accurately identify existing or predict future metastatic disease in patients with osteosarcoma since the majority of patients present with undetectable micrometastatic disease. We previously repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2d34b2b9b1e4359484d43cd9e26b28
https://doi.org/10.1007/s11999-008-0361-x
https://doi.org/10.1007/s11999-008-0361-x
Publikováno v:
Clinical Orthopaedics and Related Research. 466:2131-2146
Establishing the best diagnosis for musculoskeletal neoplasms requires a multidisciplinary approach using clinical, radiographic, and histologic analyses. Despite this rigorous approach, establishing accurate diagnoses and prognoses remains challengi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382452cd01630722caa5e7139df6360a
https://doi.org/10.1007/s11999-008-0342-0
https://doi.org/10.1007/s11999-008-0342-0
Publikováno v:
Clinical Orthopaedics and Related Research. 466:2114-2130
Osteosarcoma is the most common nonhematologic malignancy of bone in children and adults. The peak incidence occurs in the second decade of life, with a smaller peak after age 50. Osteosarcoma typically arises around the growth plate of long bones. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1bc9fd43f5947027e8160b377be415
https://doi.org/10.1007/s11999-008-0335-z
https://doi.org/10.1007/s11999-008-0335-z
Publikováno v:
Clinical Orthopaedics and Related Research. 466:2099-2106
Analysis of global protein expression, an approach known as expression proteomics, can offer important clues for understanding tumor biology that cannot be obtained by other approaches (e.g., genome or transcriptome analysis). Using two-dimensional d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172486290412ace21f9d120cb81e6c36
https://doi.org/10.1007/s11999-008-0330-4
https://doi.org/10.1007/s11999-008-0330-4
Publikováno v:
Clinical Orthopaedics and Related Research. 466:2092-2098
Modulation of apoptosis may influence sarcoma pathogenesis and/or aggressiveness. The Fas death pathway, mediated by FasL or TGFbeta, is one of two apoptotic pathways. Recent studies report that EGF can modulate TGFbeta and/or FasL expression/activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8179815754bf2e2ff51b1983bf0f7aef
https://doi.org/10.1007/s11999-008-0313-5
https://doi.org/10.1007/s11999-008-0313-5
Autor:
Ashley N. Rettew, Ryan M. Garcia, Patrick J. Messerschmitt, Robert E. Brookover, Patrick J Getty, Edward M. Greenfield
Inhibitors of specific tyrosine kinases are attractive lead compounds for development of targeted chemotherapies for many tumors, including osteosarcoma. We asked whether inhibition of specific tyrosine kinases would decrease the motility, colony for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18753f18b90b85bc836f996c694c8abe
https://europepmc.org/articles/PMC2493014/
https://europepmc.org/articles/PMC2493014/
Synovial sarcoma is a rare sarcoma of unknown histologic origin. We previously reported the gene expression profile of synovial sarcoma was closely related to that of malignant peripheral nerve sheath tumors, and the fibroblast growth factor (FGF) si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f582f857d7001363bf8b07d6a381eee9
https://europepmc.org/articles/PMC2493002/
https://europepmc.org/articles/PMC2493002/
Given the effective immunotherapy of DC-based vaccine in other cancers, we hypothesized DC-based vaccines would induce effective immune responses against Ewing's sarcoma. To verify this hypothesis and develop the most effective dendritic cell vaccine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1ea396ac12a2b2d8729ec0355db1be
https://europepmc.org/articles/PMC2493000/
https://europepmc.org/articles/PMC2493000/
Synovial sarcomas are highly aggressive mesenchymal cancers that show modest response to conventional cytotoxic chemotherapy, suggesting a definite need for improved biotargeted agents. Progress has been hampered by the lack of insight into pathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd2d8349f2f0c3de233ee2d5f84c81e
https://europepmc.org/articles/PMC2492998/
https://europepmc.org/articles/PMC2492998/
High-dose methotrexate is a standard component in the treatment of osteogenic sarcoma. Impaired methotrexate uptake associated with decreased reduced folate carrier expression is a common mechanism of methotrexate resistance in osteogenic sarcoma sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f678ecf49741b2038a2f54937d8ef2a
https://europepmc.org/articles/PMC2493020/
https://europepmc.org/articles/PMC2493020/