Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Symeon Siniossoglou"'
Autor:
Wolfram Antonin, Symeon Siniossoglou
Publikováno v:
Cells, Vol 11, Iss 24, p 4120 (2022)
The nuclear envelope constitutes a selective barrier that segregates chromatin into the nucleus of eukaryotic cells [...]
Externí odkaz:
https://doaj.org/article/4b15b9fe88d84c53bd663f2ac46be442
Autor:
Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235746 (2020)
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms. Therefore, it is important to identify new drug targets for drug discovery and novel therap
Externí odkaz:
https://doaj.org/article/69957f3095894e4e9a1f75421cbf0efb
Publikováno v:
Communicative & Integrative Biology, Vol 9, Iss 4 (2016)
Survival during starvation depends largely on metabolic energy, which is stored in the form of neutral lipids in specialized organelles known as lipid droplets. The precursors for the synthesis of neutral lipids are also used for membrane biogenesis,
Externí odkaz:
https://doaj.org/article/77f3be8f7897412ba802335b03d81a7b
Publikováno v:
The FEBS Journal. 287:4838-4843
The regulation of lipid homeostasis is essential for normal cell physiology, and its disruption can lead to disease. Lipid droplets (LDs) are ubiquitous organelles dedicated to storing nonpolar lipids that are used for metabolic energy production or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e71a655132a5495b8ce55a0c8f4c1ca
https://doi.org/10.1111/febs.15307
https://doi.org/10.1111/febs.15307
Autor:
Emily R. Rowe, Michael L. Mimmack, Antonio D. Barbosa, Afreen Haider, Iona Isaac, Myriam M. Ouberai, Abdou Rachid Thiam, Satish Patel, Vladimir Saudek, Symeon Siniossoglou, David B. Savage
Publikováno v:
Journal of Biological Chemistry. 298:101490
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::098a5fd1df19af5c935bc2edde71f7a9
https://doi.org/10.1016/j.jbc.2021.101490
https://doi.org/10.1016/j.jbc.2021.101490
Autor:
Maya Schuldiner, James R. Edgar, Symeon Siniossoglou, Lihi Gal, Muriel Mari, Albert Koulman, Koini Lim, Antonio Daniel Barbosa, Peter Sterk, David B. Savage, Philip A. Wigge, Benjamin Jenkins, Fulvio Reggiori
Publikováno v:
Developmental Cell, 50(6), 755-766.e6. CELL PRESS
Barbosa, A D, Lim, K, Mari, M, Edgar, J R, Gal, L, Sterk, P, Jenkins, B J, Koulman, A, Savage, D B, Schuldiner, M, Reggiori, F, Wigge, P A & Siniossoglou, S 2019, ' Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization ', Developmental Cell, vol. 50, no. 6, pp. 755-766.e6 . https://doi.org/10.1016/j.devcel.2019.07.009
Developmental Cell
Barbosa, A D, Lim, K, Mari, M, Edgar, J R, Gal, L, Sterk, P, Jenkins, B J, Koulman, A, Savage, D B, Schuldiner, M, Reggiori, F, Wigge, P A & Siniossoglou, S 2019, ' Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization ', Developmental Cell, vol. 50, no. 6, pp. 755-766.e6 . https://doi.org/10.1016/j.devcel.2019.07.009
Developmental Cell
Summary Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the building blocks of organelle membranes, or remodeling of their fatty-acyl (FA) compositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bcd76ccc1910091eeed2cc49e2003e
https://research.rug.nl/en/publications/e284ef4a-b7ff-4094-a6aa-bae36869a954
https://research.rug.nl/en/publications/e284ef4a-b7ff-4094-a6aa-bae36869a954
Autor:
Xuejie Wang, Kai Liu, Weitao Chen, Zhongping Yao, Jian-Ying Wang, Symeon Siniossoglou, Na Lu, Xu Wang, Chao Yang
Publikováno v:
Neuron. 105(2)
How adult neurons coordinate lipid metabolism to regenerate axons remains elusive. We found that depleting neuronal lipin1, a key enzyme controlling the balanced synthesis of glycerolipids through the glycerol phosphate pathway, enhanced axon regener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713c9c9e604275240260951d70c3e7b7
https://pubmed.ncbi.nlm.nih.gov/31972142
https://pubmed.ncbi.nlm.nih.gov/31972142
Autor:
Gil-Soo Han, Merce Miranda, Juan Guardiola, George M. Carman, Cristóbal Moreno, Jordi Capellades, Oscar Yanes, Symeon Siniossoglou, Antonio Zorzano, Cristóbal Richart, David Sebastián, Martin Wabitsch, Ana Temprano, Hiroshi Sembongi
Publikováno v:
Diabetologia
Aims/hypothesis In mammals, the evolutionary conserved family of Mg2+-dependent phosphatidate phosphatases (PAP1), involved in phospholipid and triacylglycerol synthesis, consists of lipin-1, lipin-2 and lipin-3. While mutations in the murine Lpin1 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2449f9795c090c935ffb0a74b7c2659
http://europepmc.org/articles/PMC4969345
http://europepmc.org/articles/PMC4969345
Autor:
Joseph T. Nickels, Antonio Daniel Barbosa, Symeon Siniossoglou, Michelle L. Villasmil, Jessie Lee Cunningham
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235746 (2020)
PLoS ONE, Vol 15, Iss 7, p e0235746 (2020)
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms. Therefore, it is important to identify new drug targets for drug discovery and novel therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02142288cb64a49105676afb7244603
https://doi.org/10.1371/journal.pone.0235746
https://doi.org/10.1371/journal.pone.0235746
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1864(9)
Storage of non-polar lipids in ubiquitous eukaryotic organelles, lipid droplets (LDs), prevents the toxic consequences of unesterified fatty acids and provides a lipid reservoir that can be promptly used to satisfy cellular needs under multiple metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfe6a8cbc275bc809f69e7b1508c51d
https://pubmed.ncbi.nlm.nih.gov/28390906
https://pubmed.ncbi.nlm.nih.gov/28390906