Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Symeon M. Koulas"'
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Akademický článek
Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways
Autor: Anastasia S. Tsagkarakou, Styliani A. Chasapi, Symeon M. Koulas, Ioannis Tsialtas, Efthimios Kyriakis, Christina E. Drakou, Sándor Kun, László Somsák, Georgios A. Spyroulias, Anna-Maria G. Psarra, Demetres D. Leonidas
Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 3, Iss , Pp 100011- (2021)
The binding of p-coumaroyl glucose to glycogen phosphorylase (GP; a pharmaceutical target for the development of antihyperglycaemic drugs) has been studied by kinetics, and X-ray crystallography while its effect to HepG2 cells metabolism has been ass
Externí odkaz: https://doaj.org/article/a49cf742850049f58c1a058409ebcdff
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3
Akademický článek
High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-β-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors
Autor: Thomas Fischer, Symeon M. Koulas, Anastasia S. Tsagkarakou, Efthimios Kyriakis, George A. Stravodimos, Vassiliki T. Skamnaki, Panagiota G.V. Liggri, Spyros E. Zographos, Rainer Riedl, Demetres D. Leonidas
Publikováno v: Molecules, Vol 24, Iss 7, p 1322 (2019)
Structure-based design and synthesis of two biphenyl-N-acyl-β-d-glucopyranosylamine derivatives as well as their assessment as inhibitors of human liver glycogen phosphorylase (hlGPa, a pharmaceutical target for type 2 diabetes) is presented. X-ray
Externí odkaz: https://doaj.org/article/b9197cf13d4b429d8c5405c18af6b576
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4
Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode
Autor: Athanasios Mallouchos, Symeon M. Koulas, Ioannis Tsialtas, Christina E. Drakou, Serafeim Alexopoulos, Chrysavgi Gardeli, Anna-Maria G. Psarra, Demetres Asimakopoulos, Demetres D. Leonidas, Vasiliki T Skamnaki, Anastasia S. Tsagkarakou
Publikováno v: Journal of Agricultural and Food Chemistry. 68:10191-10199
Anthocyanins (ACNs) are dietary phytochemicals with an acknowledged therapeutic significance. Pomegranate juice (PJ) is a rich source of ACNs with potential applications in nutraceutical development. Glycogen phosphorylase (GP) catalyzes the first st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ea4b6b26af18db74bc401564c2c8a9
https://doi.org/10.1021/acs.jafc.0c04205
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5
Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways
Autor: Ioannis Tsialtas, Symeon M. Koulas, Styliani A. Chasapi, Demetres D. Leonidas, Christina E. Drakou, Sándor Kun, Anna-Maria G. Psarra, Georgios A. Spyroulias, Anastasia S. Tsagkarakou, László Somsák, Efthimios Kyriakis
Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 3, Iss, Pp 100011-(2021)
The binding of p-coumaroyl glucose to glycogen phosphorylase (GP; a pharmaceutical target for the development of antihyperglycaemic drugs) has been studied by kinetics, and X-ray crystallography while its effect to HepG2 cells metabolism has been ass
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811d59c708b50751e435a8bc20475f13
http://www.sciencedirect.com/science/article/pii/S277241742100011X
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