Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Symantas Ragauskas"'
Autor:
Inesa Lelyte, Vidhya R. Rao, Giedrius Kalesnykas, Symantas Ragauskas, Simon Kaja, Zubair Ahmed
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Diabetic retinopathy (DR) is a multifactorial disease displaying vascular-associated pathologies, including vascular leakage and neovascularization, ultimately leading to visual impairment. However, animal models accurately reflecting these
Externí odkaz:
https://doaj.org/article/95bca3c8ce294d8c8cbb15c797015760
Autor:
Henri Leinonen, Velta Keksa-Goldsteine, Symantas Ragauskas, Philip Kohlmann, Yajuvinder Singh, Ekaterina Savchenko, Jooseppi Puranen, Tarja Malm, Giedrius Kalesnykas, Jari Koistinaho, Heikki Tanila, Katja M. Kanninen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The Finnish variant of late infantile neuronal ceroid lipofuscinosis (CLN5 disease) belongs to a family of neuronal ceroid lipofuscinosis (NCLs) diseases. Vision loss is among the first clinical signs in childhood forms of NCLs. Mutations in
Externí odkaz:
https://doaj.org/article/bb6f6dcb4fdd4a55869968c7e9693326
Autor:
Harri Elamaa, Minna Kihlström, Emmi Kapiainen, Mika Kaakinen, Ilkka Miinalainen, Symantas Ragauskas, Marc Cerrada-Gimenez, Satu Mering, Marjut Nätynki, Lauri Eklund
Publikováno v:
eLife, Vol 7 (2018)
The maintenance of fluid homeostasis is necessary for function of the neural retina; however, little is known about the significance of potential fluid management mechanisms. Here, we investigated angiopoietin-4 (Angpt4, also known as Ang3), a poorl
Externí odkaz:
https://doaj.org/article/336523bacb18459e80fe0bee7916a2e3
Autor:
Symantas Ragauskas, Henri Leinonen, Jooseppi Puranen, Seppo Rönkkö, Soile Nymark, Kestutis Gurevicius, Arto Lipponen, Outi Kontkanen, Jukka Puoliväli, Heikki Tanila, Giedrius Kalesnykas
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113317 (2014)
Huntington's disease (HD) is an inherited neurodegenerative disorder that primarily affects the medium-size GABAergic neurons of striatum. The R6/2 mouse line is one of the most widely used animal models of HD. Previously the hallmarks of HD-related
Externí odkaz:
https://doaj.org/article/8f5a4c0ad30c4f1583d229f60ec6e934
Autor:
Jost B. Jonas, Marc Cerrada-Gimenez, Giedrius Kalesnykas, Mukharram M. Bikbov, Symantas Ragauskas, Timur A. Khalimov
Publikováno v:
International Ophthalmology
Introduction To examine the compatibility of intravitreally injected epidermal growth factor (EGF) and amphiregulin as EGF family member. Methods Four rabbits (age: 4 months; body weight: 2.5 kg) received three intravitreal injections of EGF (100 ng)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b6330957c94337c85609cfdc012201
https://doi.org/10.1007/s10792-021-01761-w
https://doi.org/10.1007/s10792-021-01761-w
Autor:
Karolina Losenkova, Akira Takeda, Symantas Ragauskas, Marc Cerrada-Gimenez, Maria Vähätupa, Simon Kaja, Marius L. Paul, Constanze C. Schmies, Georg Rolshoven, Christa E. Müller, Jouko Sandholm, Sirpa Jalkanen, Giedrius Kalesnykas, Gennady G. Yegutkin
Publikováno v:
Cellular and Molecular Life Sciences. 79
ATP and adenosine have emerged as important signaling molecules involved in vascular remodeling, retinal functioning and neurovascular coupling in the mammalian eye. However, little is known about the regulatory mechanisms of purinergic signaling in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9e47fff3564e83ba322c099857abf2
https://doi.org/10.1007/s00018-022-04187-4
https://doi.org/10.1007/s00018-022-04187-4
Autor:
Symantas Ragauskas, Anita K. Ghosh, Donatas Neverauskas, Jonathan M. Eby, Agne Žiniauskaitė, Robertas Cesna, Simon Kaja
Publikováno v:
Alcohol. 96:101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b72e92535adfe116a0dd75db934070bd
https://doi.org/10.1016/j.alcohol.2021.09.014
https://doi.org/10.1016/j.alcohol.2021.09.014
Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology
Autor:
Soile Nymark, Hannele Uusitalo-Järvinen, Jari Hyttinen, Symantas Ragauskas, Jenni J. Hakkarainen, Hannu Uusitalo, Virpi Alarautalahti, Giedrius Kalesnykas
Publikováno v:
Investigative ophthalmologyvisual science. 60(6)
Purpose: Retinal explant cultures provide simplified systems where the functions of the retina and the effects of ocular therapies can be studied in an isolated environment. The purpose of this study was to provide insight into long-term preservation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f23e6431b61b25fb5e962b28f1716e
https://pubmed.ncbi.nlm.nih.gov/31042799
https://pubmed.ncbi.nlm.nih.gov/31042799
Autor:
Jenni J. Hakkarainen, Symantas Ragauskas, Simon Kaja, Giedrius Kalesnykas, Aila Seppänen, Mika Reinisalo
Publikováno v:
International Journal of Pharmaceutics. 511:73-78
The purpose of the study was to devise a fast, reliable and sensitive cell viability assay for assessment of acute cytotoxicity on human corneal epithelial cells by using a clinically relevant exposure time. Acute cytotoxic effects of the pharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354c28e2ecfa7f3f2d3bfef93ccdab8b
https://doi.org/10.1016/j.ijpharm.2016.06.135
https://doi.org/10.1016/j.ijpharm.2016.06.135
Autor:
Harri Elamaa, Ilkka Miinalainen, Emmi Kapiainen, Satu Mering, Mika Kaakinen, Lauri Eklund, Marjut Nätynki, Marc Cerrada-Gimenez, Symantas Ragauskas, Minna Kihlström
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d1526ab16b1e71e62914e05a98a335
https://doi.org/10.7554/elife.37776.034
https://doi.org/10.7554/elife.37776.034
