Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sylwia Szeląg-Pieniek"'
Autor:
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Lukasz Skalski, Sylwia Szeląg-Pieniek, Mariola Post, Arkadiusz Parus, Marta Syczewska, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4543
Volume 24
Issue 5
Pages: 4543
Hepatic drug metabolizing enzymes (DMEs), whose activity may be affected by liver diseases, are major determinants of drug pharmacokinetics. Hepatitis C liver samples in different functional states, i.e., the Child–Pugh class A (n = 30), B (n = 21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adab54949117ba28fdd46fc5032fb3dc
https://doi.org/10.3390/ijms24054543
https://doi.org/10.3390/ijms24054543
Autor:
Stefan Oswald, Joanna Łapczuk-Romańska, Mateusz Kurzawski, Sylwia Szeląg-Pieniek, Marek Droździk, Maciej Wrzesiński
Publikováno v:
Pharmacological Reports
Background Hepatic enzymes involved in drug metabolism vary markedly in expression, abundance and activity, which affects individual susceptibility to drugs and toxicants. The present study aimed to compare mRNA expression and protein abundance of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95aedf573ad2c506e70b3126f531d38a
https://pubmed.ncbi.nlm.nih.gov/34741761
https://pubmed.ncbi.nlm.nih.gov/34741761
Autor:
Marek Droździk, Joanna Lapczuk-Romanska, Christoph Wenzel, Łukasz Skalski, Sylwia Szeląg-Pieniek, Mariola Post, Marta Syczewska, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7947
Transmembrane drug transport in hepatocytes is one of the major determinants of drug pharmacokinetics. In the present study, ABC transporters (P-gp, MRP1, MRP2, MRP3, MRP4, BCRP, and BSEP) and SLC transporters (MCT1, NTCP, OAT2, OATP1B1, OATP1B3, OAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d5237737c142188a8ae90f5a62f120
https://doi.org/10.3390/ijms23147947
https://doi.org/10.3390/ijms23147947
Autor:
Stefan Oswald, Mariola Post, Marek Droździk, Mateusz Kurzawski, Joanna Łapczuk-Romańska, Sylwia Szeląg-Pieniek
Publikováno v:
Pharmacological Reports
Background Wilson’s disease is a genetic disorder inherited in a recessive manner, caused by mutations in the copper-transporter ATP7B. Although it is a well-known disease, currently available treatments are far from satisfactory and their efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8442bf9cc712f9b60a609b6d5e10fc
https://pubmed.ncbi.nlm.nih.gov/34117631
https://pubmed.ncbi.nlm.nih.gov/34117631
Autor:
Pawel Domagala, Mariola Post, Marek Droździk, Joanna Łapczuk-Romańska, Stefan Oswald, Sylwia Szeląg-Pieniek, Janusz Miętkiewski, Mateusz Kurzawski, Justyna Grzegółkowska
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1606 (2020)
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1606 (2020)
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb0ab06c109ebab996f758b5ca52892
Autor:
Stefan Oswald, Marek Droździk, Maciej Wrzesiński, Mateusz Kurzawski, Sylwia Szeląg-Pieniek, Jerzy Sieńko, Joanna Łapczuk-Romańska
Publikováno v:
Pharmacological reports : PR. 71(4)
Background Analysis of results and conclusions in studies dedicated to pathology of the liver are usually based on comparison of pathological liver specimens and control/reference (considered as healthy) tissues. There are two main sources of the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0228dc077cab75cacf3927613a0f12c
https://pubmed.ncbi.nlm.nih.gov/31207436
https://pubmed.ncbi.nlm.nih.gov/31207436
Autor:
Barbara Gawrońska-Szklarz, Marek Droździk, Sylwia Szeląg-Pieniek, Urszula Adamiak-Giera, Elżbieta Wyska, Mateusz Kurzawski
Genetycznie uwarunkowana aktywność enzymów metabolizujących leki może mieć znaczenie dla bezpieczeństwa i skuteczności leczenia. We wcześniejszych badaniach wykazano, że na aktywność enzymatyczną CYP2C19 może wpływać nie tylko polimor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9633446962671c6944f73170f16a1374
https://ruj.uj.edu.pl/xmlui/handle/item/122105
https://ruj.uj.edu.pl/xmlui/handle/item/122105
Autor:
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Sylwia Szelag-Pieniek, Mariola Post, Łukasz Skalski, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1334 (2021)
Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and
Externí odkaz:
https://doaj.org/article/5d8fca0e121047dd9394a9be7c6ec67c