Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sylwia Szeląg-Pieniek"'
Autor:
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Lukasz Skalski, Sylwia Szeląg-Pieniek, Mariola Post, Arkadiusz Parus, Marta Syczewska, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4543 (2023)
Hepatic drug metabolizing enzymes (DMEs), whose activity may be affected by liver diseases, are major determinants of drug pharmacokinetics. Hepatitis C liver samples in different functional states, i.e., the Child–Pugh class A (n = 30), B (n = 21)
Externí odkaz:
https://doaj.org/article/7afe6b9a50bc4df0bc1e924080b91291
Autor:
Marek Droździk, Joanna Lapczuk-Romanska, Christoph Wenzel, Łukasz Skalski, Sylwia Szeląg-Pieniek, Mariola Post, Marta Syczewska, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7947 (2022)
Transmembrane drug transport in hepatocytes is one of the major determinants of drug pharmacokinetics. In the present study, ABC transporters (P-gp, MRP1, MRP2, MRP3, MRP4, BCRP, and BSEP) and SLC transporters (MCT1, NTCP, OAT2, OATP1B1, OATP1B3, OAT
Externí odkaz:
https://doaj.org/article/fa8c5606dbee4c3abc2d7ebfa2367d31
Autor:
Marek Droździk, Sylwia Szeląg-Pieniek, Justyna Grzegółkowska, Joanna Łapczuk-Romańska, Mariola Post, Pawel Domagała, Janusz Miętkiewski, Stefan Oswald, Mateusz Kurzawski
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1606 (2020)
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function.
Externí odkaz:
https://doaj.org/article/86d54646980a4b6e81c1af1bd57ca1fb
Autor:
Stefan Oswald, Joanna Łapczuk-Romańska, Mateusz Kurzawski, Sylwia Szeląg-Pieniek, Marek Droździk, Maciej Wrzesiński
Publikováno v:
Pharmacological Reports
Background Hepatic enzymes involved in drug metabolism vary markedly in expression, abundance and activity, which affects individual susceptibility to drugs and toxicants. The present study aimed to compare mRNA expression and protein abundance of th
Autor:
Stefan Oswald, Mariola Post, Marek Droździk, Mateusz Kurzawski, Joanna Łapczuk-Romańska, Sylwia Szeląg-Pieniek
Publikováno v:
Pharmacological Reports
Background Wilson’s disease is a genetic disorder inherited in a recessive manner, caused by mutations in the copper-transporter ATP7B. Although it is a well-known disease, currently available treatments are far from satisfactory and their efficacy
Autor:
Pawel Domagala, Mariola Post, Marek Droździk, Joanna Łapczuk-Romańska, Stefan Oswald, Sylwia Szeląg-Pieniek, Janusz Miętkiewski, Mateusz Kurzawski, Justyna Grzegółkowska
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1606 (2020)
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1606 (2020)
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function.
Autor:
Stefan Oswald, Marek Droździk, Maciej Wrzesiński, Mateusz Kurzawski, Sylwia Szeląg-Pieniek, Jerzy Sieńko, Joanna Łapczuk-Romańska
Publikováno v:
Pharmacological reports : PR. 71(4)
Background Analysis of results and conclusions in studies dedicated to pathology of the liver are usually based on comparison of pathological liver specimens and control/reference (considered as healthy) tissues. There are two main sources of the con
Autor:
Barbara Gawrońska-Szklarz, Marek Droździk, Sylwia Szeląg-Pieniek, Urszula Adamiak-Giera, Elżbieta Wyska, Mateusz Kurzawski
Genetycznie uwarunkowana aktywność enzymów metabolizujących leki może mieć znaczenie dla bezpieczeństwa i skuteczności leczenia. We wcześniejszych badaniach wykazano, że na aktywność enzymatyczną CYP2C19 może wpływać nie tylko polimor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9633446962671c6944f73170f16a1374
https://ruj.uj.edu.pl/xmlui/handle/item/122105
https://ruj.uj.edu.pl/xmlui/handle/item/122105
Autor:
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Sylwia Szelag-Pieniek, Mariola Post, Łukasz Skalski, Mateusz Kurzawski, Stefan Oswald
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1334 (2021)
Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and
Externí odkaz:
https://doaj.org/article/5d8fca0e121047dd9394a9be7c6ec67c
Autor:
Maryam Gholizadeh, Sylwia Szelag-Pieniek, Mariola Post, Mateusz Kurzawski, Jesus Prieto, Josepmaria Argemi, Marek Drozdzik, Lars Kaderali
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7368 (2020)
Liver diseases are important causes of morbidity and mortality worldwide. The aim of this study was to identify differentially expressed microRNAs (miRNAs), target genes, and key pathways as innovative diagnostic biomarkers in liver patients with dif
Externí odkaz:
https://doaj.org/article/9e3952a4fcc84070b6ec37f1197e9e5c