Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sylwia Huber"'
Autor:
Tim E. Moors, Daniel Mona, Stefan Luehe, Gonzalo Duran-Pacheco, Liz Spycher, Olaf Mundigl, Klaus Kaluza, Sylwia Huber, Melanie N. Hug, Thomas Kremer, Mirko Ritter, Sebastian Dziadek, Gregor Dernick, Wilma D. J. van de Berg, Markus Britschgi
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Based on immunostainings and biochemical analyses, certain post-translationally modified alpha-synuclein (aSyn) variants, including C-terminally truncated (CTT) and Serine-129 phosphorylated (pSer129) aSyn, are proposed to be involved in the
Externí odkaz:
https://doaj.org/article/7462bb934f3b4b95bbbd0d8a65c4f8ea
Autor:
Manaswini Sivaramakrishnan, Kathleen D. McCarthy, Sébastien Campagne, Sylwia Huber, Sonja Meier, Angélique Augustin, Tobias Heckel, Hélène Meistermann, Melanie N. Hug, Pascale Birrer, Ahmed Moursy, Sarah Khawaja, Roland Schmucki, Nikos Berntenis, Nicolas Giroud, Sabrina Golling, Manuel Tzouros, Balazs Banfai, Gonzalo Duran-Pacheco, Jens Lamerz, Ying Hsiu Liu, Thomas Luebbers, Hasane Ratni, Martin Ebeling, Antoine Cléry, Sergey Paushkin, Adrian R. Krainer, Frédéric H.-T. Allain, Friedrich Metzger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Small molecules correcting the splicing deficit of the survival of motor neuron 2 (SMN2) gene have been identified as having therapeutic potential. Here, the authors provide evidence that SMN2 mRNA forms a ribonucleoprotein complex that can be specif
Externí odkaz:
https://doaj.org/article/86ed63c63e664f938352b802e813bfcc
Autor:
Nadine Ruderisch, Daniel Schlatter, Andreas Kuglstatter, Wolfgang Guba, Sylwia Huber, Carlo Cusulin, Jörg Benz, Arne Christian Rufer, Joerg Hoernschemeyer, Christophe Schweitzer, Tina Bülau, Achim Gärtner, Eike Hoffmann, Jens Niewoehner, Christoph Patsch, Karlheinz Baumann, Hansruedi Loetscher, Eric Kitas, Per-Ola Freskgård
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 76-92 (2017)
Therapeutic approaches to fight Alzheimer's disease include anti-Amyloidβ (Aβ) antibodies and secretase inhibitors. However, the blood-brain barrier (BBB) limits the brain exposure of biologics and the chemical space for small molecules to be BBB p
Externí odkaz:
https://doaj.org/article/316ddf067d1746b19366ae2a8f354fcb
Autor:
Annie Moisan, Marcel Gubler, Jitao David Zhang, Yann Tessier, Kamille Dumong Erichsen, Sabine Sewing, Régine Gérard, Blandine Avignon, Sylwia Huber, Fethallah Benmansour, Xing Chen, Roberto Villaseñor, Annamaria Braendli-Baiocco, Matthias Festag, Andreas Maunz, Thomas Singer, Franz Schuler, Adrian B. Roth
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 89-105 (2017)
Antisense oligonucleotide (AON) therapeutics offer new avenues to pursue clinically relevant targets inaccessible with other technologies. Advances in improving AON affinity and stability by incorporation of high affinity nucleotides, such as locked
Externí odkaz:
https://doaj.org/article/6a19a17eb817471d91d25a02041685db
Autor:
Iwan Zimmermann, Pascal Egloff, Cedric AJ Hutter, Fabian M Arnold, Peter Stohler, Nicolas Bocquet, Melanie N Hug, Sylwia Huber, Martin Siegrist, Lisa Hetemann, Jennifer Gera, Samira Gmür, Peter Spies, Daniel Gygax, Eric R Geertsma, Roger JP Dawson, Markus A Seeger
Publikováno v:
eLife, Vol 7 (2018)
Mechanistic and structural studies of membrane proteins require their stabilization in specific conformations. Single domain antibodies are potent reagents for this purpose, but their generation relies on immunizations, which impedes selections in th
Externí odkaz:
https://doaj.org/article/0128ad13246b41d488888b761db2ce68
Autor:
Sabine Sewing, Adrian B Roth, Michael Winter, Andreas Dieckmann, Cristina Bertinetti-Lapatki, Yann Tessier, Claudia McGinnis, Sylwia Huber, Erich Koller, Corinne Ploix, John C Reed, Thomas Singer, Andreas Rothfuss
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187574 (2017)
Single-stranded oligonucleotides (ON) comprise a promising therapeutic platform that enables selective modulation of currently undruggable targets. The development of novel ON drug candidates has demonstrated excellent efficacy, but in certain cases
Externí odkaz:
https://doaj.org/article/50e4d29434af416b9fb4beb0c1a70d7a
Autor:
Sylwia Huber, Fabio Casagrande, Melanie N Hug, Lisha Wang, Philipp Heine, Lutz Kummer, Andreas Plückthun, Michael Hennig
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0175842 (2017)
The neurotensin receptor 1 represents an important drug target involved in various diseases of the central nervous system. So far, the full exploitation of potential therapeutic activities has been compromised by the lack of compounds with favorable
Externí odkaz:
https://doaj.org/article/263952a649e24caeb01f9f211d01ff10
Autor:
Jean-Pierre Dangy, Nicole Scherr, Philipp Gersbach, Melanie N Hug, Raphael Bieri, Claudio Bomio, Jun Li, Sylwia Huber, Karl-Heinz Altmann, Gerd Pluschke
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 6, p e0004808 (2016)
Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, causes extensive tissue destruction by inducing apoptosis of host cells. In this study, we aimed at the production of antibodies that could neutralize the cytotoxic activities of
Externí odkaz:
https://doaj.org/article/11c0217f06474003a3e7220ac419925d
Autor:
Eric-André Kusznir, Jean-Christophe Hau, Michaela Portmann, Anne-Gaëlle Reinhart, Fabio Falivene, Jessica Bastien, Jesper Worm, Alfred Ross, Matthias Lauer, Philippe Ringler, Filippo Sladojevich, Sylwia Huber, Konrad Bleicher, Michael Keller
Publikováno v:
Bioconjugate Chemistry. 34:866-879
Autor:
Markus Britschgi, Thomas Kremer, Klaus Kaluza, Jeroen Kole, Evelien Timmermans-Huisman, Christina A. Maat, Wagner Zago, Mirko Ritter, Olaf Mundigl, Tim Moors, Robin Barbour, Daniel Niedieker, Samir F. El-Mashtoly, Jeroen J. G. Geurts, Liz Spycher, Melanie N. Hug, Sebastian Dziadek, Klaus Gerwert, Wilma D.J. van de Berg, Sylwia Huber, Dennis Petersen, Daniel Mona
Publikováno v:
Acta Neuropathologica
Moors, T E, Maat, C A, Niedieker, D, Mona, D, Petersen, D, Timmermans-Huisman, E, Kole, J, El-Mashtoly, S F, Spycher, L, Zago, W, Barbour, R, Mundigl, O, Kaluza, K, Huber, S, Hug, M N, Kremer, T, Ritter, M, Dziadek, S, Geurts, J J G, Gerwert, K, Britschgi, M & van de Berg, W D J 2021, ' The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy ', Acta Neuropathologica, vol. 142, no. 3, pp. 423-448 . https://doi.org/10.1007/s00401-021-02329-9
Acta Neuropathologica, 142(3), 423-448. Springer Verlag
Moors, T E, Maat, C A, Niedieker, D, Mona, D, Petersen, D, Timmermans-Huisman, E, Kole, J, El-Mashtoly, S F, Spycher, L, Zago, W, Barbour, R, Mundigl, O, Kaluza, K, Huber, S, Hug, M N, Kremer, T, Ritter, M, Dziadek, S, Geurts, J J G, Gerwert, K, Britschgi, M & van de Berg, W D J 2021, ' The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy ', Acta Neuropathologica, vol. 142, no. 3, pp. 423-448 . https://doi.org/10.1007/s00401-021-02329-9
Acta Neuropathologica, 142(3), 423-448. Springer Verlag
Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn—accumulate in Lewy bodies (LBs) in different regions of the Parkinson’s disea