imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics

Autor: Krzysztof Pastuszak, Anna Supernat, Myron G. Best, Sjors G.J.G. In 't Veld, Sylwia Łapińska‐Szumczyk, Anna Łojkowska, Robert Różański, Anna J. Żaczek, Jacek Jassem, Thomas Würdinger, Tomasz Stokowy

Publikováno v: Molecular Oncology, Vol 15, Iss 10, Pp 2688-2701 (2021)

Liquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor‐educated platelets. Here, we developed the imPlatelet c

Externí odkaz: https://doaj.org/article/adeeef4060b14a0db9cd2dae0a2c0c27

Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study

Autor: Yue Gao, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Gui-Ling Li, Sjors G J G In ‘t Veld, Guang-Yao Cai, Gui-Yan Xie, Shao-Qing Zeng, Yuan Wu, Jian-Hua Chi, Jia-Hao Liu, Qiong Zhang, Xiao-Fei Jiao, Lin-Li Shi, Wan-Rong Lu, Wei-Guo Lv, Xing-Sheng Yang, Jurgen M J Piek, Cornelis D de Kroon, C A R Lok, Anna Supernat, Sylwia Łapińska-Szumczyk, Anna Łojkowska, Anna J Żaczek, Jacek Jassem, Bakhos A Tannous, Nik Sol, Edward Post, Myron G Best, Bei-Hua Kong, Xing Xie, Ding Ma, Thomas Wurdinger, An-Yuan Guo, Qing-Lei Gao

Publikováno v: Gao, Y, Liu, C-J, Li, H-Y, Xiong, X-M, Li, G-L, in 't Veld, S G J G, Cai, G-Y, Xie, G-Y, Zeng, S-Q, Wu, Y, Chi, J-H, Liu, J-H, Zhang, Q, Jiao, X-F, Shi, L-L, Lu, W-R, Lv, W-G, Yang, X-S, Piek, J M J, de Kroon, C D, Lok, C A R, Supernat, A, Łapińska-Szumczyk, S, Łojkowska, A, Żaczek, A J, Jassem, J, Tannous, B A, Sol, N, Post, E, Best, M G, Kong, B-H, Xie, X, Ma, D, Wurdinger, T, Guo, A-Y & Gao, Q-L 2023, ' Platelet RNA enables accurate detection of ovarian cancer : an intercontinental, biomarker identification study ', Protein & cell, vol. 14, no. 6, pp. 433-447 . https://doi.org/10.1093/procel/pwac056
Protein & cell. Higher Education Press

Platelets are reprogrammed by cancer via a process called education, which favors cancer development. The transcriptional profile of tumor-educated platelets (TEPs) is skewed and therefore practicable for cancer detection. This intercontinental, hosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3501931432af99a06df56403d9512a8
https://doi.org/10.1093/procel/pwac056

Abstract LB168: Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study

Autor: Yue Gao, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Sjors G.j.g. In ‘t Veld, Gui-Ling Li, Jia-Hao Liu, Guang-Yao Cai, Gui-Yan Xie, Shao-Qing Zeng, Yuan Wu, Jian-Hua Chi, Qiong Zhang, Xiao-Fei Jiao, Lin-Li Shi, Wan-Rong Lu, Wei-Guo Lv, Xing-Sheng Yang, Jurgen M.j. Piek, Cornelis D de Kroon, C.a.r. Lok, Anna Supernat, Sylwia Łapińska-Szumczyk, Anna Łojkowska, Anna J. Żaczek, Jacek Jassem, Bakhos A. Tannous, Nik Sol, Edward Post, Myron G. Best, Bei-Hua Kong, Xing Xie, Ding Ma, Thomas Wurdinger, An-Yuan Guo, Qing-Lei Gao

Publikováno v: Cancer Research. 82:LB168-LB168

Background: Morpho-physiological alternations of platelets provided a rationale to harness RNA sequencing of tumor-educated platelets (TEPs) for preoperative diagnosis of cancer. Timely, accurate, and non-invasive detection of ovarian cancer in women

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b242f4b2fb00c3072c6e3f6de4a1d01e
https://doi.org/10.1158/1538-7445.am2022-lb168

Platelet RNA Signature Enables Early and Accurate Detection of Ovarian Cancer: An Intercontinental, Biomarker Identification Study

Autor: Yue Gao, Chun-Jie Liu, Xiaoming Xiong, Sjors G.J.G. In ‘t Veld, Guiling Li, Huayi Li, Jiahao Liu, Guangyao Cai, Gui-Yan Xie, Shaoqing Zeng, Yuan Wu, Jianhua Chi, Qiong Zhang, Xiaofei Jiao, linli shi, wanrong lu, Weiguo Lu, Xingsheng Yang, Jurgen M.J. Piek, Cornelis D de Kroon, C.A.R. Lok, Anna Supernat, Sylwia Łapińska-Szumczyk, Anna Łojkowska, Anna J Żaczek, Jacek Jassem, Bakhos A. Tannous, Nik Sol, Edward Post, Myron G. Best, Beihua Kong, Xing Xie, Ding Ma, Thomas Wurdinger, An-yuan Guo, Qinglei Gao

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18c6624e439f10da37bd068c48069a20
https://doi.org/10.2139/ssrn.3928491

Tumor Heterogeneity at Protein Level as an Independent Prognostic Factor in Endometrial Cancer

Autor: Jacek Gulczyński, Dariusz Wydra, Sylwia Łapińska-Szumczyk, Wojciech Biernat, Anna Supernat, Anna J. Żaczek, Hanna Majewska

Publikováno v: Translational Oncology, Vol 7, Iss 5, Pp 613-619 (2014)
Translational Oncology

Intratumor heterogeneity implies heterogeneous protein function, facilitating tumor adaptation which results in therapeutic failure. We hypothesized that tumor heterogeneity at protein level may influence the course of the disease. As a single biopsy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa180692eb15b19d3f41dd0b6ebe07c
http://www.sciencedirect.com/science/article/pii/S1936523314000734