Výsledky vyhledávání - "Sylwia, Szymczak"

Akademický článek

Case Report: Complete pathologic response to neoadjuvant selpercatinib in a patient with resectable early-stage RET fusion-positive non-small cell lung cancer

Autor: Jonathan W. Goldman, Lynette M. Sholl, Sanja Dacic, Michael C. Fishbein, Yonina R. Murciano-Goroff, Ravi Rajaram, Sylwia Szymczak, Anna M. Szpurka, Bo H. Chao, Alexander Drilon

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

The LIBRETTO-001 trial demonstrated the activity of the selective rearrangement during transfection (RET) inhibitor selpercatinib in advanced RET fusion-positive non-small cell lung cancer (NSCLC) and resulted in the drug’s approval for this indica

Externí odkaz: https://doaj.org/article/ff2adc6f3eaf4f15b17c63e038b1aa62

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Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid tumours (LIBRETTO-001): a phase 1/2, open-label, basket trial

Autor: Vivek, Subbiah, Jürgen, Wolf, Bhavana, Konda, Hyunseok, Kang, Alexander, Spira, Jared, Weiss, Masayuki, Takeda, Yuichiro, Ohe, Saad, Khan, Kadoaki, Ohashi, Victoria, Soldatenkova, Sylwia, Szymczak, Loretta, Sullivan, Jennifer, Wright, Alexander, Drilon

Publikováno v: The Lancet Oncology. 23:1261-1273

Selpercatinib is a first-in-class, highly selective RET kinase inhibitor with CNS activity that has shown efficacy in RET fusion-positive lung and thyroid cancers. RET fusions occur rarely in other tumour types. We aimed to investigate the efficacy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3c5a7ba9e08650e6904334833fb7d4
https://doi.org/10.1016/s1470-2045(22)00541-1

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Selpercatinib in Patients With RET Fusion–Positive Non–Small-Cell Lung Cancer: Updated Safety and Efficacy From the Registrational LIBRETTO-001 Phase I/II Trial

Autor: Alexander Drilon, Vivek Subbiah, Oliver Gautschi, Pascale Tomasini, Filippo de Braud, Benjamin J. Solomon, Daniel Shao-Weng Tan, Guzmán Alonso, Jürgen Wolf, Keunchil Park, Koichi Goto, Victoria Soldatenkova, Sylwia Szymczak, Scott S. Barker, Tarun Puri, Aimee Bence Lin, Herbert Loong, Benjamin Besse

Publikováno v: Scientia

Selpercatinib; Lung cancer; Safety Selpercatinib; Cáncer de pulmón; Seguridad Selpercatinib; Càncer de pulmó; Seguretat PURPOSE Selpercatinib, a first-in-class, highly selective, and potent CNS-active RET kinase inhibitor, is currently approved f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7234be8c79bdb581bfe91eff1f129bac
https://hdl.handle.net/11351/9323

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Selpercatinib in Patients With

Autor: Alexander, Drilon, Vivek, Subbiah, Oliver, Gautschi, Pascale, Tomasini, Filippo, de Braud, Benjamin J, Solomon, Daniel, Shao-Weng Tan, Guzmán, Alonso, Jürgen, Wolf, Keunchil, Park, Koichi, Goto, Victoria, Soldatenkova, Sylwia, Szymczak, Scott S, Barker, Tarun, Puri, Aimee, Bence Lin, Herbert, Loong, Benjamin, Besse

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 41(2)

Selpercatinib, a first-in-class, highly selective, and potent CNS-active RET kinase inhibitor, is currently approved for the treatment of patients withPatients were enrolled to LIBRETTO-001, a phase I/II, single-arm, open-label study of selpercatinib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::765195bda1dd85cefc6dfb87f1c727c7
https://pubmed.ncbi.nlm.nih.gov/36207414

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LIBRETTO-001 cohort 7: A single-arm, phase 2 study of neoadjuvant selpercatinib in patients with resectable stage IB-IIIA RET fusion-positive NSCLC

Autor: Ravi Rajaram, Lynette M. Sholl, Sanja Dacic, Jonathan W. Goldman, Daniel Shao-Weng Tan, Oliver Gautschi, Herbert H. F. Loong, Filippo G. De Braud, Erminia Massarelli, Benjamin Philip Levy, Grace K. Dy, Suhyun Kang, Sylwia Szymczak, Bo H. Chao, Alexander E. Drilon

Publikováno v: Journal of Clinical Oncology. 40:TPS8594-TPS8594

TPS8594 Background: Despite definitive surgery and perioperative chemotherapy, many patients with locoregional non-small cell lung cancer (NSCLC) continue to experience recurrent disease and limited survival. Although targeted therapies are standard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05b8aafecd854c39e9965b0dec945ad9
https://doi.org/10.1200/jco.2022.40.16_suppl.tps8594

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Tumor agnostic efficacy of selpercatinib in patients with RET fusion+ solid tumors: A global, multicenter, registrational trial update (LIBRETTO-001)

Autor: Vivek Subbiah, Juergen Wolf, Bhavana Konda, Hyunseok Kang, Alexander I. Spira, Jared Weiss, Masayuki Takeda, Yuichiro Ohe, Saad A. Khan, Kadoaki Ohashi, Victoria Soldatenkova, Sylwia Szymczak, Loretta Sullivan, Jennifer Wright, Alexander E. Drilon

Publikováno v: Journal of Clinical Oncology. 40:3094-3094

3094 Background: Selpercatinib, a first-in-class highly selective and potent RET kinase inhibitor, is approved in multiple countries for the treatment of lung and thyroid cancer with RET fusions and medullary thyroid cancer with RET mutations. We pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23587115a3db75f28971e2802c53c66b
https://doi.org/10.1200/jco.2022.40.16_suppl.3094

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Increased estrogen receptor β expression correlates with decreased spine formation in the rat hippocampus

Autor: Katarzyna Kalita, Alena Savonenko, Leszek Kaczmarek, Sylwia Szymczak, Istvan Merchenthaler, Alicja L. Markowska, Jacek Jaworski, Basia Mioduszewska

Publikováno v: Hippocampus. 16:453-463

Estrogens play an important role in the brain function acting through two receptor types, ERalpha and ERbeta, both well-recognized as transcription factors. In this study, we investigated the ERbeta mRNA and protein levels in the rat hippocampus by u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf88a583df08807c387dfc9502158e1
https://doi.org/10.1002/hipo.20172

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Non-nuclear estrogen receptor ? and ? in the hippocampus of male and female rats

Autor: Katarzyna Kalita, Sylwia Szymczak, Leszek Kaczmarek

Publikováno v: Hippocampus. 15:404-412

Estrogens play important roles in the brain, acting through two receptor types, ERalpha and ERbeta, both recognized as transcription factors. In this study, we investigated the ERbeta mRNA and protein expression in the male and female rat brain, focu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5223302bae4fc27598cd2a397b10105
https://doi.org/10.1002/hipo.20066

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Non-nuclear estrogen receptor beta and alpha in the hippocampus of male and female rats

Autor: Katarzyna, Kalita, Sylwia, Szymczak, Leszek, Kaczmarek

Publikováno v: Hippocampus. 15(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7218fd4d365d4da9f850f3a5240313f
https://pubmed.ncbi.nlm.nih.gov/15669092

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