Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sylvie Perachon"'
Autor:
Pierre Sokoloff, Ulrich R. Mach, Sandrine Ferry, Jean-Charles Schwartz, Holger Stark, Sylvie Perachon, Camille G. Wermuth, Anneke E. Hackling
Publikováno v:
ChemBioChem. 5:508-518
Based on N-alkylated 1,2,3,4-tetrahydroisoquinoline derivatives, which are structurally related to the partial agonist BP 897, a series of novel, selective dopamine D3 receptor antagonists has been synthesised. Derivatisation included changes in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14182e8892fd02799bc1cde6293f375c
https://doi.org/10.1002/cbic.200300784
https://doi.org/10.1002/cbic.200300784
Autor:
Pierre Sokoloff, Bernard Le Foll, Sophie Ridray, Régis Bordet, Sylvie Perachon, Jean-Charles Schwartz
Publikováno v:
Neurotoxicity Research. 3:433-441
Hedonic and reinforcing properties of drugs of abuse are closely related to brain dopamine neuron activity. All these drugs increase dopamine release in the shell of the nucleus accumbens, a brain region in which neurons co-express the D1 (D1R) and D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271d76436030db3bbb5a2a2b55ac140f
https://doi.org/10.1007/bf03033202
https://doi.org/10.1007/bf03033202
Autor:
Norbert Matzanke, Holger Stark, Sylvie Perachon, Pierre Sokoloff, Werner Löwe, Jean-Charles Schwartz
Publikováno v:
European Journal of Medicinal Chemistry. 34:791-798
With a straightforward seven-step synthesis, racemic perhydro[1,4]benzoxazin-6-on was synthesized in overall good yields via regioselective epoxid ring-opening to the corresponding β-aminoalcohol. The oxazine derivative was the key intermediate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6970d756b912aaf4b926b4e6f65b6e29
https://doi.org/10.1016/s0223-5234(99)00213-5
https://doi.org/10.1016/s0223-5234(99)00213-5
Autor:
Camille G. Wermuth, André Mann, F. Sautel, Sylvie Perachon, Barry J. Everitt, Maria Pilla, Pierre Sokoloff, Fabrice Garrido, Jean-Charles Schwartz
Publikováno v:
Nature. 400:371-375
Environmental stimuli that are reliably associated with the effects of many abused drugs, especially stimulants such as cocaine, can produce craving and relapse in abstinent human substance abusers. In animals, such cues can induce and maintain drug-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29e632dcac199c6148d9aa5eb1587db
https://doi.org/10.1038/22560
https://doi.org/10.1038/22560
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c29233ff5b176ac34352f1bfdedb2d89
https://doi.org/10.1002/chin.200006167
https://doi.org/10.1002/chin.200006167
Autor:
Jean-Charles Schwartz, Oliver Saur, Anneke E. Hackling, Holger Stark, Pierre Sokoloff, Sylvie Perachon
Publikováno v:
ChemInform. 38
A series of eight substituted N-(4-(4-(2-halogenophenyl)piperazin-1-yl)butyl)-3-phenylacryl amide derivatives have been synthesized and screened for binding affinities at dopamine hD(2) and hD(3) receptors. All compounds have shown high to remarkable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3402ac81beda2f05017df5ac393b3a6
https://doi.org/10.1002/chin.200731134
https://doi.org/10.1002/chin.200731134
Autor:
Andre Mann, Pierre Sokoloff, Sylvie Perachon, Anneke E. Hackling, Jean-Charles Schwartz, Wolfgang Sippl, Camille G. Wermuth, Holger Stark, Robin Ghosh, Hans-Dieter Höltje
Publikováno v:
Journal of medicinal chemistry. 46(18)
The dopamine D(3) receptor is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders. Targetting high affinity and D(3) versus D(2) receptor-preferring ligands, the partial agonist BP 897 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce381698a36d30389bddb521c318906a
https://pubmed.ncbi.nlm.nih.gov/12930150
https://pubmed.ncbi.nlm.nih.gov/12930150
Autor:
Catalina Betancur, Pierre Sokoloff, Sylvie Perachon, Jean-Charles Schwartz, William Rostène, C. Pilon
Publikováno v:
Neuroreport. 11(1)
Dopamine agonist-induced hypothermia has been proposed to be mediated by the D3 receptor (D3R), as it is elicited by (+)7-OH-DPAT and antagonized by S 14297, two putative D3R-preferential ligands. Here we show, however, that S 14297 is a full and par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7feebd086367e3b36c8d5881a8813a11
https://pubmed.ncbi.nlm.nih.gov/10683862
https://pubmed.ncbi.nlm.nih.gov/10683862
Publikováno v:
European journal of pharmacology. 366(2-3)
We measured the affinities of bromocriptine, pramipexole, pergolide and ropinirole at human recombinant dopamine D1, D2 and D3 receptors in binding and functional tests. All four compounds bound with high affinity at the dopamine D3 receptor; bromocr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b10637671f3bf1e3876f8bd30698821
https://pubmed.ncbi.nlm.nih.gov/10082211
https://pubmed.ncbi.nlm.nih.gov/10082211
Publikováno v:
Psychotropes. 8:115
Les proprietes hedoniques et renforcantes des drogues sont reliees a leur interaction avec les systemes dopaminergiques cerebraux. Toutes les drogues entrainent une elevation de dopamine dans l’ecorce du noyau accumbens, une region cerebrale qui co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::092f8ea3c00d1428b50d71af18da5073
https://doi.org/10.3917/psyt.081.0115
https://doi.org/10.3917/psyt.081.0115