Glycoprotein V : the unsolved GPV puzzle

Autor: Quentin Kimmerlin, Sylvie Moog, Catherine Ravanat, Catherine Strassel, François Lanza

Publikováno v: Platelets, Vol 33, Iss 6, Pp 833-840 (2022)

Glycoprotein V (GPV) is a highly expressed 82 KDa platelet surface transmembrane protein which is loosely attached to the GPIb-IX complex. Despite remaining questions concerning its function, GPV presents several unique features which have repercussi

Externí odkaz: https://doaj.org/article/76415790333d41a4915a3b3d92b5c83e

Mutations in the most divergent α-tubulin isotype, α8-tubulin, cause defective platelet biogenesis

Autor: Carsten Janke, François Lanza, Anita Eckly, Véronique Heim, Claude Férec, Claire Weber, Quentin Kimmerlin, Véronique Henriot, Christian Gachet, Arnaud Dupuis, Paul Gueguen, Satish Bodakuntla, Sylvie Moog

Publikováno v: Journal of thrombosis and haemostasis : JTHREFERENCES. 20(2)

Background In the panel of genes commonly associated with inherited macrothrombocytopenia, an important fraction encodes key cytoskeletal proteins such as tubulin isotypes, the building blocks of microtubules. Macrothrombocytopenia causing mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c123523cc44a9717626a77e5635d1d7
https://pubmed.ncbi.nlm.nih.gov/34704371

Correction: An essential role for α4A-tubulin in platelet biogenesis

Autor: Catherine Strassel, Maria M Magiera, Arnaud Dupuis, Morgane Batzenschlager, Agnès Hovasse, Irina Pleines, Paul Guéguen, Anita Eckly, Sylvie Moog, Léa Mallo, Quentin Kimmerlin, Stéphane Chappaz, Jean-Marc Strub, Natarajan Kathiresan, Henri de la Salle, Alain Van Dorsselaer, Claude Ferec, Jean-Yves Py, Christian Gachet, Christine Schaeffer-Reiss, Benjamin T Kile, Carsten Janke, François Lanza

Publikováno v: Life Science Alliance

Alpha4A-tubulin is the predominant α-tubulin isotype in platelets. Mutations in α4A-tubulin cause abnormal platelet biogenesis and marginal band formation in mice and in a patient, establishing an essential role of this tubulin isotype.
During

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fa5421aaa841b624c56c869dc21eaf
https://doi.org/10.26508/lsa.202101132

An essential role for α4A-tubulin in platelet biogenesis

Autor: Alain Van Dorsselaer, Claude Férec, Arnaud Dupuis, Benjamin T. Kile, Christine Schaeffer-Reiss, Carsten Janke, Morgane Batzenschlager, Irina Pleines, François Lanza, Paul Gueguen, Léa Mallo, Anita Eckly, Maria M. Magiera, Jean Marc Strub, Catherine Strassel, Christian Gachet, Sylvie Moog, Jean-Yves Py, Agnès Hovasse, Quentin Kimmerlin, Stephane Chappaz, Natarajan Kathiresan

Publikováno v: Life Science Alliance
Life Science Alliance, Life Science Alliance LLC, 2019, ⟨10.26508/lsa.201900309⟩
Life Science Alliance, 2019, ⟨10.26508/lsa.201900309⟩

During platelet biogenesis, microtubules (MTs) are arranged into submembranous structures (the marginal band) that encircle the cell in a single plane. This unique MT array has no equivalent in any other mammalian cell, and the mechanisms responsible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aac9af1ca31fb80173e427660815c6
https://hal.archives-ouvertes.fr/hal-02375062/document

Biosynthesis of platelet glycoprotein V expressed as a single subunit or in association with GPIb-IX

Autor: Jean-Pierre Cazenave, Sylvie Moog, François Lanza, Catherine Strassel, Marie-Jeanne Baas

Publikováno v: European Journal of Biochemistry. 271:3671-3677

Glycoprotein (GP) V is noncovalently linked to GPIbα, GPIbβ and GPIX within the platelet GPIb–V–IX complex, a receptor for von Willebrand factor and thrombin. Two functions have been ascribed to GPV, namely, the modulation of thrombin- and coll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9796798c240c1ad238e89db9864add6f
https://doi.org/10.1111/j.1432-1033.2004.04304.x