Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sylvie M. Sur"'
Autor:
Sylvie M. Sur, Xun Shen, Andrea M. Peier, Yi Pei, William T. McElroy, Serena Xu, Andy Liaw, Jing Li, Edward Hudak, Tony Kreamer, Meiping Chang, Kristine Devito, Xi Ai, Elizabeth Smith
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(10)
Interactions between transmembrane receptors and their ligands play important roles in normal biological processes and pathological conditions. However, the binding partners for many transmembrane-like proteins remain elusive. To identify potential l
Autor:
Joel M. Harris, Xiaoping Zhou, John A. Morrow, Sue-Ing Lin, Marco A. S. Baptista, John M. Sanders, Xiaoping Zhang, Hong Mei, Mark W. Embrey, Sylvie M. Sur, Duane E. DeMong, Ravi P. Nargund, Alan Hruza, Heather E. Tiscia, Matthew J. Fell, Zhizhang Yin, Gautam Agnihotri, Honglu Zhang, Thomas J. Greshock, Jack D. Scott, Yinghui Lin, Zhi-Cai Shi, John A. Mccauley, Sarah W. Li, Ronald K. Chang, Mark T. Bilodeau, Michael W. Miller, Reshma Kuvelkar, Andrew Stamford, Marc Poirier, Hong Liu, Megan K. Macala, Kallol Basu, Li Xiao, Lynn A. Hyde, Jonathan T. Kern, Xing Dai, Christian Mirescu, Paul L. Walsh, Matthew E. Kennedy, John J. Renger, Zhiyong Hu, John Columbus, Robert E. Drolet, Eric M. Parker
Publikováno v:
Journal of medicinal chemistry. 60(7)
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a kinase domain and GTPase domain among other regions. Individuals possessing gain of function mutations in the kinase domain such as the most prevalent G2019S mutati
Autor:
John A. McCauley, Ronald K. Chang, Thomas J. Greshock, Ming-Tain Lai, John M. Sanders, Hemaka A. Rajapakse, Hua Su, Robert E. Drolet, Rosa I. Sanchez, Sylvie M. Sur, John J. Renger, Jonathan T. Kern, Heather E. Tiscia, Rada Vanessa L, Mark T. Bilodeau, Boyoung Kim
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(11)
Familial Parkinson's disease cases have recently been associated with the leucine rich repeat kinase 2 (LRRK2) gene. It has been hypothesized that inhibition of the LRRK2 protein may have the potential to alter disease pathogenesis. A dihydrobenzothi
Autor:
Owen B. McManus, William A. Schmalhofer, Dong-Ming Shen, Sylvie M. Sur, Gregory J. Kaczorowski, Min Shu, Andra Stevenson, Tarak Shah, Maria L. Garcia, James B. Doherty, Ge Dai, Ravi P. Nargund, Guilherme Suarez-Kurtz, Cristiano G Ponte, Laszlo Kiss
Publikováno v:
Molecular Pharmacology. 81:567-577
High-conductance calcium-activated potassium (Maxi-K) channels are present in smooth muscle where they regulate tone. Activation of Maxi-K channels causes smooth muscle hyperpolarization and shortening of action-potential duration, which would limit
Autor:
Cuyue Tang, Kerry L. Fillgrove, Marlene A. Jacobson, Pete H. Hutson, Chris Culberson, Sylvie M. Sur, Yuhsin Kuo, John M. Sanders, Mark E. Layton, Mark E. Fraley, George D. Hartman, Robert M. Garbaccio, Brian C. Magliaro, Sarah L. Huszar, Jason M. Uslaner, Edward J. Brnardic, Julie A. O'Brien
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3129-3133
Hit to lead optimization of (5R)-5-hexyl-3-phenyl-1,3-oxazolidin-2-one as a positive allosteric modulator of mGluR2 is described. Improvements in potency and metabolic stability were achieved through SAR on both ends of the oxazolidinone. An optimize