Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sylvie Janssens"'
Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain
Autor:
Sylvie Janssens, Michael Schotsaert, Rahul Karnik, Vinod Balasubramaniam, Marion Dejosez, Alexander Meissner, Adolfo García-Sastre, Thomas P. Zwaka
Publikováno v:
mSystems, Vol 3, Iss 1 (2018)
ABSTRACT Zika virus (ZIKV) infection during early pregnancy can cause microcephaly and associated defects at birth, but whether it can induce neurologic sequelae that appear later in life remains unclear. Using a model of the developing brain based o
Externí odkaz:
https://doaj.org/article/85074777e2c546da9892c43e0bfaf410
Autor:
Junko Tsuji, Jin Wang, David Cohen, Jianjun Zhang, Jijun Yu, Ignacio I. Wistuba, Tomas Vilimas, Len Taing, Li Chen, Chunhua Yan, Qing-Rong Chen, Magdalena Thurin, Rebecca A. Enos, Xiaoman Wang, Peng Jiang, Candace Patterson, Mohamed Uduman, Catherine J. Wu, Beatriz Sanchez-Espiridion, Aashna Jhaveri, Yang Liu, Andrew Futreal, Jingxin Fu, Jiexin Zhang, Jack Lee, Donna Neuberg, Curtis Gumbs, Xin Huang, Sylvie Janssens, Collin Tokheim, Zexian Zeng, Avinash Das Sahu, Ming Tang, Carrie Cibulskis, James Lindsay, Cu Nguyen, Jason L. Weirather, Joyce Yu, Stacey Gabriel, Ethan Cerami, Dzifa Y. Duose, Daoud Meerzaman, Chris Karlovich, Sharmistha Sarkar, X. Shirley Liu, Biswajit Das, Sachet A. Shukla, Jianhua Zhang
Publikováno v:
Clin Cancer Res
Purpose: Whole-exome (WES) and RNA sequencing (RNA-seq) are key components of cancer immunogenomic analyses. To evaluate the consistency of tumor WES and RNA-seq profiling platforms across different centers, the Cancer Immune Monitoring and Analysis
Autor:
Minkyung Song, Sean C. Bendall, Melissa D. Bowman, James Lindsay, Diane Marie Del Valle, J. Jack Lee, Cathy Rowe, Gerold Bongers, Jenny Peterson-Klaus, James H. Doroshow, Valerie M. Tatard-Leitman, F. Stephen Hodi, Holden T. Maecker, Chia-Chi Chang, Sacha Gnjatic, David Patton, Srinika Ranasinghe, Ethan Cerami, Lyndsay Harris, Jeffrey S. Abrams, Magdalena Thurin, Stacey J Adam, Ignacio I. Wistuba, Rebecca A. Enos, Helen X. Chen, Margaret M. Mooney, Sylvie Janssens, Robert R. Jenq, Elad Sharon, Howard Streicher, Chantale Bernatchez, Mina Pichavant, Joyce Yu, Stephen M. Hewitt, Catherine J. Wu, Beatriz Sanchez-Espiridion, Xiaole Shirley Liu, Radim Moravec, Ming Tang, Gheath Alatrash
Publikováno v:
Clin Cancer Res
Purpose: Immunoprofiling to identify biomarkers and integration with clinical trial outcomes are critical to improving immunotherapy approaches for patients with cancer. However, the translational potential of individual studies is often limited by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d123c2ad19f463e523105dab86b951fc
https://europepmc.org/articles/PMC8491462/
https://europepmc.org/articles/PMC8491462/
Autor:
Sylvie Janssens, Viviana Simon, Lara Manganaro, Michael Schotsaert, Thomas P. Zwaka, Marion Dejosez, Adolfo García-Sastre
Publikováno v:
Current protocols in stem cell biology. 48(1)
Organoids-or pluripotent stem cell-derived in vitro-grown simplified mini organs-have become a tremendously important model to study human organ development and disease. To restrict the noise inherent to the heterogeneous cell mixtures derived from o
Autor:
Sylvie Janssens, Zack Thill
Publikováno v:
Journal des anthropologues. :317-338
Azraq, a rural village in north-eastern Jordan, was once famous for its luxurious marshes and wetlands but today is starved of water. This paper looks at the role of water as a crucial medium in the definition and consolidation of contemporary relati
Autor:
Rasoul Pourebrahim, Hong Thi Ht Tran, Rob Houtmeyers, Stephen M Ghogomu, Tobias Langenberg, Eric Bellefroid, Sylvie Janssens, Jean Jaques Cassiman, Kris Vleminckx, Aurore Thelie, Sabine Tejpar
Publikováno v:
Journal of Biological Chemistry. 286:37732-37740
The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of β-
Autor:
Olaf Van Den Broek, Ian R. Davenport, Stefan Hoppler, Gert Jan C. Veenstra, Sylvie Janssens, Olivier Destrée, Fei Liu, Robbert C. Akkers, Kris Vleminckx
Publikováno v:
International Journal of Developmental Biology, 57, 1, pp. 49-54
International Journal of Developmental Biology, 57, 49-54
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
International Journal of Developmental Biology, 57, 49-54
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
TCF1 belongs to the family of LEF1/TCF transcription factors that regulate gene expression downstream of Wnt/b-catenin signaling, which is crucial for embryonic development and is involved in adult stem cell regulation and tumor growth. In early Xeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce095ef3125976a1e319dbebfb05d61
https://hdl.handle.net/2066/120010
https://hdl.handle.net/2066/120010
Autor:
Karine Parain, Muriel Perron, Odile Bronchain, Belaid Sekkali, Hong Thi Tran, Sylvie Janssens, Kris Vleminckx, Nicolas Mazurier, Morgane Locker, Pauline Cabochette, Caroline Borday
Publikováno v:
Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2012, 139 (19), pp.3499-509. ⟨10.1242/dev.079582⟩
Development (Cambridge, England), Company of Biologists, 2012, 139 (19), pp.3499-509. ⟨10.1242/dev.079582⟩
International audience; Continuous neurogenesis in the adult nervous system requires a delicate balance between proliferation and differentiation. Although Wnt/β-catenin and Hedgehog signalling pathways are thought to share a mitogenic function in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8edb2845da441412023192f9f667aa
https://hal.archives-ouvertes.fr/hal-00739966
https://hal.archives-ouvertes.fr/hal-00739966
Publikováno v:
The International journal of developmental biology. 54(10)
During and after gastrulation, the neural axis in vertebrates is patterned along the antero-posterior axis by the combined activity of signaling factors secreted in the neural ectoderm and the underlying mesoderm. These signals divide the neural axis