Výsledky vyhledávání - "Sylvie Goncalves-Contal"

Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminum to β,γ-Unsaturated α-Ketoamides: Efficient Access to γ-Methyl-Substituted Carbonyl Compounds

Autor: Ludovic Gremaud, Alexandre Alexakis, Sylvie Goncalves-Contal

Publikováno v: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Angewandte Chemie: International Edition, Vol. 52, No 48 (2013) pp. 12701-12704

Picture perfect: By using the reagent trimethylaluminium and β,γ-unsaturated α-ketoamides, 1,4-adducts were obtained with perfect 1,4-regioselectivity and good to excellent yields and ee values. The potential synthetic utility of the methodology w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c535311339d5261afe1035c4dd0004d3
https://doi.org/10.1002/anie.201306541

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Copper-Catalyzed Enantioselective Conjugate Addition to α,β-Unsaturated Aldehydes with Various Organometallic Reagents

Autor: Lucille Babel, Sylvie Goncalves-Contal, Laetitia Palais, Alexandre Alexakis, Ludovic Gremaud

Publikováno v: Synthesis, Vol. 48, No 19 (2016) pp. 3301-3308

β-Substituted aldehydes constitute a very important class of compounds found in nature. Synthesis of this motif can be envisioned by C–C bond formation on enals. For this purpose, we report herein the development of enantioselective copper-catalyz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8bff8299f63e2f07af8c728438b3b8
https://archive-ouverte.unige.ch/unige:86676

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ChemInform Abstract: Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminum to β,γ-Unsaturated α-Ketoamides: Efficient Access to γ-Methyl-Substituted Carbonyl Compounds

Autor: Alexandre Alexakis, Ludovic Gremaud, Sylvie Goncalves-Contal

Publikováno v: ChemInform. 45

The asymmetric addition of AlMe3 to β,γ-unsaturated α-ketoamides affords 1,4-adducts with perfect 1,4-regioselectivity and good to excellent yields and enantioselectivity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e9a67de4f5e78bdae994e04242b40bc
https://doi.org/10.1002/chin.201417085

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Direct Organocatalytic Construction of Bicyclo[3.2.1]octanes by Domino Michael/Aldol Reaction with β,γ-Unsaturated 1,2-Keto Amides

Autor: Laure Guénée, Sylvie Goncalves-Contal, Alice Lefranc, Alexandre Alexakis

Publikováno v: Synlett, Vol. 25, No 20 (2014) pp. 2947-2952

A direct construction of bicyclo[3.2.1]octanes by an organocatalytic domino Michael/Aldol reaction of cyclic 1,3-keto esters with β,γ-unsaturated 1,2-keto amides is reported. Formation of a precipitate corresponding to the racemic co-crystals of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5d347661b35da03853459de5fea4a1
https://archive-ouverte.unige.ch/unige:43001

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