Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sylvie Gomez"'
Publikováno v:
Criminocorpus, Vol 19
Externí odkaz:
https://doaj.org/article/824ece36ea314fc48014ac8ce735519f
Autor:
Niall M. B. Martin, Heather Mary Ellen Duggan, Kurt Gordon Pike, Sarah L. Pass, Marc Geoffrey Hummersone, Sylvie Gomez, Karine Malagu, Linette Ruston, Keith Allan Menear, Martin Pass
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1212-1216
The optimization of a potent and highly selective series of dual mTORC1 and mTORC2 inhibitors is described. An initial focus on improving cellular potency whilst maintaining or improving other key parameters, such as aqueous solubility and margins ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15eea519b035c89ee1cf3976ed0ca6d
https://doi.org/10.1016/j.bmcl.2013.01.019
https://doi.org/10.1016/j.bmcl.2013.01.019
Autor:
Sylvie Gomez, Karine Malagu, Thomas Presnot, Sally Ewen, Mihiro Sunose, Xiao-Ling Fan Cockcroft, Niall M. B. Martin, Alexandra Fundo, Armelle Le Gall, Keith Allan Menear, Hermann Gesine Johanna, Luisa Sebastian, Kristel Blackburn, Ian Hickson, Christine Bailey, Graeme C. M. Smith, Eleanor Torode, Kurt Gordon Pike
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5898-5901
A pharmacophore mapping approach, derived from previous experience of PIKK family enzymes, was used to identify a hit series of selective inhibitors of the mammalian target of rapamycin (mTOR). Subsequent refinement of the SAR around this hit series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5847355afd0c1842bfbfbdcbcce2b812
https://doi.org/10.1016/j.bmcl.2009.08.069
https://doi.org/10.1016/j.bmcl.2009.08.069
Autor:
Robin Alec Fairhurst, Joseph D. Fullerton, David Andrew Sandham, Heinz E. Moser, Mauro Zurini, Sandra Haberthuer, Darryl Brynley Jones, Mark Dodds, Julia Hatto, Gurdip Bhalay, Colin Howes, Paul Nicklin, Simon J. Watson, David Farr, Reto Naef, Irene Muller, Andrew Dunstan, Nichola J. Arnold, Nicholas James Devereux, Morris Tweed, Angela Glen, Katharine L. Turner, Beate Leuenberger, David Beer, Sylvie Gomez, Ruth Arnold, Thomas H. Keller, Stephen Paul Collingwood, Sarah Craig
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2376-2379
Inhibitors of PDE5 are useful therapeutic agents for treatment of erectile dysfunction. A series of novel xanthine derivatives has been identified as potent inhibitors of PDE5, with good levels of selectivity against other PDE isoforms, including PDE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e21375e8e7ea71d3deb6323b8cc3fb4
https://doi.org/10.1016/j.bmcl.2006.11.019
https://doi.org/10.1016/j.bmcl.2006.11.019
Autor:
Gurdip Bhalay, David Beer, Stephen Paul Collingwood, Sarah Craig, Nicholas James Devereux, Rowan Stringer, Sandra Haberthuer, Trevor John Howe, Angela Glen, Katharine L. Turner, Andrew Dunstan, Heinz E. Moser, Ruth Arnold, Mauro Zurini, Sylvie Gomez, Paul Nicklin, Simon J. Watson, Urs Baettig, Reto Naef, David Andrew Sandham, Stephen Jelfs
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2587-2590
In clinical studies, several inhibitors of phosphodiesterase 5 (PDE5) have demonstrated utility in the treatment of erectile dysfunction. We describe herein a series of 8-aryl xanthine derivatives which function as potent PDE5 inhibitors with, in man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff42050bb668b5c21bf1217c7c6b8ce
https://doi.org/10.1016/s0960-894x(02)00480-8
https://doi.org/10.1016/s0960-894x(02)00480-8
Publikováno v:
Tetrahedron Letters. 35:2891-2894
Asymmetric protonation of achiral silyl enol ethers employing chiral proton donors is described for the first time. We have obtained modest enantiomeric excesses by carrying out these reactions in homogeneous solution. The subject of this paper is to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5b82d8e820b70ec710f369097282cbf
https://doi.org/10.1016/s0040-4039(00)76652-4
https://doi.org/10.1016/s0040-4039(00)76652-4
Publikováno v:
ResearcherID
The deracemization by enantioselective protonation of silyl enol ethers was tested using 2,2-dimethyl 5-phenyl 1,3-dioxolan 4-one 1 . The results obtained, especially with pantolactone as a chiral proton donor, are better than when the deracemization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f34996d35b59e3d1e16f7c9f4b1167
https://doi.org/10.1016/s0957-4166(00)82229-6
https://doi.org/10.1016/s0957-4166(00)82229-6
Autor:
Florine Cavelier, Jean-Luc Mercadier, Muriel Llinares, Clement Petrus, Jean Verducci, Sylvie Gomez, Robert Jacquier
Publikováno v:
Tetrahedron: Asymmetry. 4:2495-2500
This work describes a convenient and accurate method for optical purity determination of α-hydroxy acids. Their derivatization with commercially available valine methyl ester affords diastereoisomers easily separable by HPLC using achiral C18 column
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e63985e50d04db46f26e8aa37e49d376
https://doi.org/10.1016/s0957-4166(00)82228-4
https://doi.org/10.1016/s0957-4166(00)82228-4
Autor:
Sylvie Gomez
Publikováno v:
Les moralistes modernes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e267b6cd3301b448318b32351a452858
https://doi.org/10.58282/colloques.1329
https://doi.org/10.58282/colloques.1329