Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Sylvie E Blondelle"'
Autor:
Dagmar Zweytick, Bostjan Japelj, Eugenia Mileykovskaya, Mateja Zorko, William Dowhan, Sylvie E Blondelle, Sabrina Riedl, Roman Jerala, Karl Lohner
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90228 (2014)
Two types of recently described antibacterial peptides derived from human lactoferricin, either nonacylated or N-acylated, were studied for their different interaction with membranes of Escherichia coli in vivo and in model systems. Electron microsco
Externí odkaz:
https://doaj.org/article/f6e4adfa48554b3e9e33c45938a107ab
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1862:183275
The search for novel compounds to combat multi-resistant bacterial infections includes exploring the potency of antimicrobial peptides and derivatives thereof. Complementary to high-throughput screening techniques, biophysical and biochemical studies
Autor:
Karl Lohner, Sylvie E. Blondelle
Publikováno v:
Current Pharmaceutical Design. 16:3204-3211
While a well-established process for lead compound discovery in for-profit companies, high-throughput screening is becoming more popular in basic and applied research settings in academia. The development of combinatorial libraries combined with easy
Autor:
Hwee L. Ng, John Sidney, Sylvie E. Blondelle, Otto O. Yang, Harris Goldstein, Aviva Joseph, Sharon Adams, Walter J. Storkus, Ming-Ying Leung, Daniel C. Douek, Francesco M. Marincola, Keri L. Schaubert, Andrew K. Sewell, Velpandi Ayyavoo, Tedi E. Asher, Janelle R Salkowitz, Darcy B. Wilson, David Price, June Kan-Mitchell, Alessandro Sette
Publikováno v:
European Journal of Immunology. 40:1950-1962
HLA-A*0201-restricted virus-specific CD8+ cytotoxic T lymphocytes (CTLs) do not appear to control HIV effectively in vivo. To enhance the immunogenicity of a highly conserved subdominant epitope, TV9 (TLNAWVKVV, p24 Gag19–27), mimotopes were design
Autor:
Dagmar Zweytick, Jörg Howe, Manfred Roessle, Guillermo Martinez de Tejada, Klaus Brandenburg, Susana Sánchez-Gómez, Jörg Andrä, Patrick Garidel, Karl Lohner, Ignacio Moriyón, Roman Jerala, Michael Rappolt, Sylvie E. Blondelle
Publikováno v:
Scopus-Elsevier
ResearcherID
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Autor:
Richard A. Houghten, Marie-Isabel Aguilar, Philip E. Thompson, Sylvie E. Blondelle, David Steer
Publikováno v:
The Journal of Peptide Research. 51:401-412
The induction and stabilisation of secondary structure for a series of amphipathic alpha-helical and beta-sheet peptides upon their binding to lipid-like surfaces has been characterised by reversed phase high-performance liquid chromatography (RP-HPL
Comparison of 55% TFA/CH2Cl2 and 100% TFA for Boc group removal during solid-phase peptide synthesis
Publikováno v:
International Journal of Peptide and Protein Research. 41:522-527
Two parallel syntheses of 40 C-terminal amide peptides, ranging in length from 4 to 20 residues, have been carried out using simultaneous multiple peptide synthesis. All synthetic steps, other than the removal of the Boc group, were performed simulta
Publikováno v:
Biochemical and Biophysical Research Communications. 369:395-400
We have studied correlation of non-lamellar phase formation and antimicrobial activity of two cationic amphipathic peptides, termed VS1-13 and VS1-24 derived from a fragment (LF11) of human lactoferricin on Escherichia coli total lipid extracts. Comp
Publikováno v:
Biopolymers. 90:683-694
Two strategies were aimed at identifying immunogenically optimized peptides for the potential use in the formulation of an effective prophylactic or therapeutic HIV-1 vaccine. Three CTL epitopes were investigated: Gag p24(19-27) TV9, Gag p17(77-85) S
Autor:
Roman Jerala, Sylvie E. Blondelle, Georg Pabst, Daniel Monreal, Jörg Andrä, Alexander Jilek, Peter M. Abuja, Guillermo Martinez de Tejada, Karl Lohner, Dagmar Zweytick
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1758(9):1426-1435
Increasing numbers of bacterial strains being resistant to conventional antibiotics emphasize the urgent need for new antimicrobial agents. One strategy is based on host defence peptides that can be found in every organism including humans. We have s