Výsledky vyhledávání - "Sylvie Diochot"

Akademický článek

Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine

Autor: Pietro Mesirca, Jean Chemin, Christian Barrère, Eleonora Torre, Laura Gallot, Arnaud Monteil, Isabelle Bidaud, Sylvie Diochot, Michel Lazdunski, Tuck Wah Soong, Stéphanie Barrère-Lemaire, Matteo E. Mangoni, Joël Nargeot

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract L-type voltage-gated calcium channels are involved in multiple physiological functions. Currently available antagonists do not discriminate between L-type channel isoforms. Importantly, no selective blocker is available to dissect the role o

Externí odkaz: https://doaj.org/article/2ab832a282b64fedbaeb690c44acc317

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Akademický článek

Report from the 29th Meeting on Toxinology, 'Toxins: From the Wild to the Lab', Organized by the French Society of Toxinology on 30 November–1 December 2023

Autor: Pascale Marchot, Ziad Fajloun, Christian Legros, Évelyne Benoit, Sylvie Diochot

Publikováno v: Toxins, Vol 16, Iss 3, p 147 (2024)

The French Society of Toxinology (SFET), which celebrated its 30th anniversary this year, organized its 29th annual Meeting (RT29), shared by 87 participants, on 30 November–1 December 2023. The RT29 main theme, “Toxins: From the Wild to the Lab�

Externí odkaz: https://doaj.org/article/7fdbad469c954d53a95c99bf169b7655

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Akademický článek

Report from the 28th Meeting on Toxinology, 'Toxins: What’s up, Doc?', Organized by the French Society of Toxinology on 28–29 November 2022

Autor: Pascale Marchot, Évelyne Benoit, Ziad Fajloun, Sylvie Diochot

Publikováno v: Toxins, Vol 15, Iss 2, p 126 (2023)

The French Society of Toxinology (SFET) organized its 28th annual meeting on 28–29 November 2022 (RT28). The central theme of this meeting was “Toxins: What’s up, Doc?”, emphasizing the latest findings on animal, bacterial, algal, plant and f

Externí odkaz: https://doaj.org/article/81043dbfe9d34e79a2837a6af5279563

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Akademický článek

Autor: Sylvie Diochot

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021)

Abstract Pain is a common symptom induced during envenomation by spiders and scorpions. Toxins isolated from their venom have become essential tools for studying the functioning and physiopathological role of ion channels, as they modulate their acti

Externí odkaz: https://doaj.org/article/2131783f03a94411bb80aeb74a30f3b4

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Akademický článek

Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects

Autor: Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, Anne Baron

Publikováno v: Toxins, Vol 14, Iss 10, p 709 (2022)

Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers to form

Externí odkaz: https://doaj.org/article/28d5b725432d4217843875ac864d4139

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Akademický článek

Report from the 27th (Virtual) Meeting on Toxinology, 'Toxins: Mr Hyde or Dr Jekyll?', Organized by the French Society of Toxinology, 9–10 December 2021

Autor: Daniel Ladant, Pascale Marchot, Sylvie Diochot, Gilles Prévost, Michel R. Popoff, Evelyne Benoit

Publikováno v: Toxins, Vol 14, Iss 2, p 110 (2022)

The French Society of Toxinology (SFET) organized its 27th annual meeting on 9–10 December 2021 as a virtual meeting (e-RT27). The central theme of this meeting was “Toxins: Mr Hyde or Dr Jekyll?”, emphasizing the latest findings on plant, fung

Externí odkaz: https://doaj.org/article/edb8be8983734be4b8815ea7e58d08ee

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Akademický článek

Report from the 26th Meeting on Toxinology, 'Bioengineering of Toxins', Organized by the French Society of Toxinology (SFET) and Held in Paris, France, 4–5 December 2019

Autor: Pascale Marchot, Sylvie Diochot, Michel R. Popoff, Evelyne Benoit

Publikováno v: Toxins, Vol 12, Iss 1, p 31 (2020)

This 26th edition of the annual Meeting on Toxinology (RT26) of the SFET (http://sfet.asso.fr/international) was held at the Institut Pasteur of Paris on 4−5 December 2019 [...]

Externí odkaz: https://doaj.org/article/35a6f0a1b81446ecb83601b246a8b84f

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Akademický článek

Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1

Autor: Sébastien Nicolas, Claude Zoukimian, Frank Bosmans, Jérôme Montnach, Sylvie Diochot, Eva Cuypers, Stephan De Waard, Rémy Béroud, Dietrich Mebs, David Craik, Didier Boturyn, Michel Lazdunski, Jan Tytgat, Michel De Waard

Publikováno v: Toxins, Vol 11, Iss 6, p 367 (2019)

Phlotoxin-1 (PhlTx1) is a peptide previously identified in tarantula venom (Phlogius species) that belongs to the inhibitory cysteine-knot (ICK) toxin family. Like many ICK-based spider toxins, the synthesis of PhlTx1 appears particularly challenging

Externí odkaz: https://doaj.org/article/e86d22f9474449df85156f8c0d4cf8f5

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Cross Pharmacological, Biochemical and Computational Studies of a Human Kv3.1b Inhibitor from

Autor: Sonia, Maatoug, Amani, Cheikh, Oussema, Khamessi, Hager, Tabka, Zied, Landoulsi, Jean-Marie, Guigonis, Sylvie, Diochot, Saïd, Bendahhou, Rym, Benkhalifa

Publikováno v: International Journal of Molecular Sciences

The voltage-gated K+ channels Kv3.1 display fast activation and deactivation kinetics and are known to have a crucial contribution to the fast-spiking phenotype of certain neurons. AahG50, as a natural product extracted from Androctonus australis hec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbd87aef13629b4c394f7a1fef750711
https://pubmed.ncbi.nlm.nih.gov/34830172

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C-Jun N-terminal kinase post-translational regulation of pain-related Acid-Sensing Ion Channels 1b and 3

Autor: Sylvie Diochot, Clément Verkest, Anne Baron, Eric Lingueglia

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2021, pp.JN-RM-0570-21. ⟨10.1523/JNEUROSCI.0570-21.2021⟩
J Neurosci

Neuronal proton-gated acid-sensing ion channels (ASICs) participate in the detection of tissue acidosis, a phenomenon often encountered in painful pathologic diseases. Such conditions often involve in parallel the activation of various signaling path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a48107a6ae8934b3c063e5fd89ac0b
https://doi.org/10.1101/2021.03.18.435937

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