Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sylvie Bourrain"'
Autor:
Robert W. Carling, Wesley Peter Blackaby, Andrew Mitchinson, Sylvie Bourrain, Richard Thomas Lewis
Publikováno v:
Tetrahedron Letters. 47:2257-2260
Novel syntheses of 2,3,8-trisubstituted pyrido[2,3- d ]pyridazines and 2,3,5-trisubstituted pyrazino[2,3- d ]pyridazines are described. Two complementary routes to pyrido[2,3- d ]pyridazines were developed, the first of which began by constructing th
Autor:
Graham Andrew Showell, Sylvie Bourrain
Publikováno v:
Synthesis. 1994:505-508
A mild reduction method of C3-oximido-1,4-benzodiazepines to afford the C3-amino derivatives is described. The key step involves the formation of a carbamate oxime intermediate. The greater reactivity of the C3-(ethylaminocarbonyl)oximido-1,4-benzodi
Autor:
Graham Andrew Showell, Sylvie Bourrain
Publikováno v:
ChemInform. 25
A mild reduction method of C3-oximido-1,4-benzodiazepines to afford the C3-amino derivatives is described. The key step involves the formation of a carbamate oxime intermediate. The greater reactivity of the C3-(ethylaminocarbonyl)oximido-1,4-benzodi
Autor:
Josephine A. Stanton, M. S. Beer, Sylvie Bourrain, Joseph G. Neduvelil, G. A. Showell, A. M. Macleod
Publikováno v:
ChemInform. 31
Autor:
Richard H. Herbert, Rosemarie Marwood, Desmond O'Connor, Sylvie Bourrain, Smita Patel, Peter H. Hutson, Robert James Maxey, James Michael Crawforth, Michael Rowley, Simon Charles Goodacre
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2701-2703
A series of 3-(4-piperidinyl)- and 3-(8-aza-bicyclo[3.2.l]oct-3-yl)-2-phenyl-1 H -indoles have been prepared and evaluated as ligands for the h5-HT 2A receptor. 3-(8-Phenethyl-8-aza-bicyclo[3.2.l]oct-3-yI)-2-phenyl-1 H -indole is a high-affinity (1.2
Autor:
Andrew Mitchinson, Richard Thomas Lewis, Wesley Peter Blackaby, Sylvie Bourrain, Robert W. Carling
Publikováno v:
ChemInform. 37
Novel syntheses of 2,3,8-trisubstituted pyrido[2,3- d ]pyridazines and 2,3,5-trisubstituted pyrazino[2,3- d ]pyridazines are described. Two complementary routes to pyrido[2,3- d ]pyridazines were developed, the first of which began by constructing th
Publikováno v:
ChemInform. 35
Regioselective rapid analogue syntheses of 1-methyl-3,5-diarylpyrazoles were developed, based on Pd-catalysed couplings to l-methyl-3(5)-arylpyrazole nonaflates, which offered an advantage in hydrolytic stability over thecorresponding triflates. The
Autor:
Rosemarie Marwood, Michael Rowley, James Michael Crawforth, Robert James Maxey, Peter H. Hutson, Sylvie Bourrain, Desmond O'Connor, Richard H. Herbert, Simon Charles Goodacre, Smita Patel
Publikováno v:
ChemInform. 32
A series of 3-(4-piperidinyl)- and 3-(8-aza-bicyclo[3.2.l]oct-3-yl)-2-phenyl-1 H -indoles have been prepared and evaluated as ligands for the h5-HT 2A receptor. 3-(8-Phenethyl-8-aza-bicyclo[3.2.l]oct-3-yI)-2-phenyl-1 H -indole is a high-affinity (1.2
Autor:
Margaret S. Beer, Josephine A. Stanton, Graham Andrew Showell, Angus Murray Macleod, Sylvie Bourrain, Joseph G. Neduvelil
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(23)
A series of 4-hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1 H -indol-3-yl)propyl] piperidines was investigated as potential selective h5-HT 1D agonists for the treatment of migraine. The 4-[(N-benzyl-N-methyl)amino]methyl analog 12a was found to be a full a
Autor:
Ian Collins, F. Emms, Smita Patel, Michael Rowley, Joseph G. Neduvelil, Kerry L. Chapman, Graham Andrew Showell, Paul D. Leeson, Sylvie Bourrain, Shil Patel, Alan E. Fletcher, Rosemarie Marwood
Publikováno v:
Bioorganicmedicinal chemistry. 6(10)
Two novel series of 3-(heterocyclylmethyl)pyrazoles have been synthesised and evaluated as ligands for the human dopamine D4 receptor. Compounds in series I (exemplified by 8k) have a phenyl ring joined to the 4-position of the pyrazole while those i