Zobrazeno 1 - 10 of 75 pro vyhledávání: '"Sylvie, Le Gall"'
1
Akademický článek
A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.
Autor: Rujapak Sutiwisesak, Nathan D Hicks, Shayla Boyce, Kenan C Murphy, Kadamba Papavinasasundaram, Stephen M Carpenter, Julie Boucau, Neelambari Joshi, Sylvie Le Gall, Sarah M Fortune, Christopher M Sassetti, Samuel M Behar
Publikováno v: PLoS Pathogens, Vol 16, Iss 10, p e1009000 (2020)
CD8 T cells provide limited protection against Mycobacterium tuberculosis (Mtb) infection in the mouse model. As Mtb causes chronic infection in mice and humans, we hypothesize that Mtb impairs T cell responses as an immune evasion strategy. TB10.4 i
Externí odkaz: https://doaj.org/article/ba98c37fa02f4bdd9e8bb26ea48d0589
Zobrazit plný text záznamu
2
Akademický článek
Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells.
Autor: Julie Boucau, Jishnu Das, Neelambari Joshi, Sylvie Le Gall
Publikováno v: PLoS Pathogens, Vol 16, Iss 3, p e1008442 (2020)
Latency reversal agents (LRA) variably induce HIV re-expression in CD4 T cells but reservoirs are not cleared. Whether HIV epitope presentation is similar between latency reversal and initial infection of CD4 T cells is unknown yet crucial to define
Externí odkaz: https://doaj.org/article/1fd33fa231404c10a62066f45a8acdcf
Zobrazit plný text záznamu
3
Akademický článek
HIV Env conserved element DNA vaccine alters immunodominance in macaques
Autor: Xintao Hu, Antonio Valentin, Margherita Rosati, Siriphan Manocheewa, Candido Alicea, Bhabadeb Chowdhury, Jenifer Bear, Kate E. Broderick, Niranjan Y. Sardesai, Sylvie Le Gall, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Publikováno v: Human Vaccines & Immunotherapeutics, Vol 13, Iss 12, Pp 2859-2871 (2017)
Sequence diversity and immunodominance are major obstacles in the design of an effective vaccine against HIV. HIV Env is a highly-glycosylated protein composed of ‘conserved’ and ‘variable’ regions. The latter contains immunodominant epitopes
Externí odkaz: https://doaj.org/article/0859607210c9494cbd90af55d9d5dd0d
Zobrazit plný text záznamu
4
Akademický článek
HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells
Autor: Blandine Monel, Annmarie McKeon, Pedro Lamothe-Molina, Priya Jani, Julie Boucau, Yovana Pacheco, R. Brad Jones, Sylvie Le Gall, Bruce D. Walker
Publikováno v: Cell Reports, Vol 27, Iss 1, Pp 142-153.e4 (2019)
Summary: Even with sustained antiretroviral therapy, resting CD4+ T cells remain a persistent reservoir of HIV infection, representing a critical barrier to curing HIV. Here, we demonstrate that CD8+ T cells recognize infected, non-activated CD4+ T c
Externí odkaz: https://doaj.org/article/e54cf213928042c08846b3e9fbd3d40e
Zobrazit plný text záznamu
7
Data from Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability
Autor: Darrell J. Irvine, Bradley L. Pentelute, Sylvie Le Gall, Na Li, Angela Q. Zhang, Mariane B. Melo, Wuhbet Abraham, Simon Liang, Jens Dinter, Mark R. Karver, Chensu Wang, Naveen K. Mehta, Rebecca L. Holden, Kelly D. Moynihan
Antitumor T-cell responses have the potential to be curative in cancer patients, but the induction of potent T-cell immunity through vaccination remains a largely unmet goal of immunotherapy. We previously reported that the immunogenicity of peptide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a24c2c28b210d6696428cca7382d88b
https://doi.org/10.1158/2326-6066.c.6549109.v1
Zobrazit plný text záznamu
9
Akademický článek
Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design
Autor: Marijana Rucevic, Julie Boucau, Jens Dinter, Georgio Kourjian, Sylvie Le Gall
Publikováno v: Viruses, Vol 6, Iss 8, Pp 3271-3292 (2014)
The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells. Despite a wealth of information about peptidases
Externí odkaz: https://doaj.org/article/d39165de441147d69ccf6c3647df545e
Zobrazit plný text záznamu
10
Akademický článek
A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells.
Autor: Zachary B Davis, Andrew Cogswell, Hamish Scott, Amanda Mertsching, Julie Boucau, Daniel Wambua, Sylvie Le Gall, Vicente Planelles, Kerry S Campbell, Edward Barker
Publikováno v: PLoS Pathogens, Vol 12, Iss 2, p e1005421 (2016)
Major histocompatibility class I (MHC-I)-specific inhibitory receptors on natural killer (NK) cells (iNKRs) tolerize mature NK cell responses toward normal cells. NK cells generate cytolytic responses to virus-infected or malignant target cells with
Externí odkaz: https://doaj.org/article/6703e51e354e43bca09bb81e0b6f0822
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje