Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Sylvie, Doublié"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
DNA polymerases catalyze nucleotidyl transfer, the central reaction in synthesis of DNA polynucleotide chains. They function not only in DNA replication, but also in diverse aspects of DNA repair and recombination. Some DNA polymerases can perform tr
Externí odkaz:
https://doaj.org/article/d2f018ed6e81486c93cf59ad46c21ad4
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009791 (2021)
Spore-forming pathogens like Clostridioides difficile depend on germination to initiate infection. During gemination, spores must degrade their cortex layer, which is a thick, protective layer of modified peptidoglycan. Cortex degradation depends on
Externí odkaz:
https://doaj.org/article/2331f6a4fdfe4f99b4a48a7423afe147
Autor:
Richard D, Wood, Sylvie, Doublié
Publikováno v:
Annual Review of Genetics. 56:207-228
DNA polymerase θ (Pol θ) is a DNA repair enzyme widely conserved in animals and plants. Pol θ uses short DNA sequence homologies to initiate repair of double-strand breaks by theta-mediated end joining. The DNA polymerase domain of Pol θ is at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f425c0e0a88ae9f1d89b2ecee7231aab
https://doi.org/10.1146/annurev-genet-072920-041046
https://doi.org/10.1146/annurev-genet-072920-041046
Autor:
Amy E Rohlfing, Brian E Eckenroth, Emily R Forster, Yuzo Kevorkian, M Lauren Donnelly, Hector Benito de la Puebla, Sylvie Doublié, Aimee Shen
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008224 (2019)
The gastrointestinal pathogen, Clostridioides difficile, initiates infection when its metabolically dormant spore form germinates in the mammalian gut. While most spore-forming bacteria use transmembrane germinant receptors to sense nutrient germinan
Externí odkaz:
https://doaj.org/article/eafb8a5d00854de29054621e32b298a0
Autor:
Susan S. Wallace, Karl E. Zahn, Brittany L. Carroll, Sylvie Doublié, John P. Hanley, Julie A. Dragon
Publikováno v:
Nucleic Acids Research
Base excision repair (BER) is the main pathway protecting cells from the continuous damage to DNA inflicted by reactive oxygen species. BER is initiated by DNA glycosylases, each of which repairs a particular class of base damage. NTHL1, a bifunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f06ded4ede037a39b89a578b48d674d
https://doi.org/10.1093/nar/gkab1162
https://doi.org/10.1093/nar/gkab1162
Publikováno v:
DNA repair. 116
DNA Polymerase θ is the key actuator of the recently identified double-strand break repair pathway, theta-mediated end joining (TMEJ). It is the only known polymerase to have a 3-domain architecture containing an independently functional family A DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516d42c6979a8bc396d48ea65bfa5a43
https://pubmed.ncbi.nlm.nih.gov/35753097
https://pubmed.ncbi.nlm.nih.gov/35753097
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0157860 (2016)
The NEIL1 DNA glycosylase is one of eleven mammalian DNA glycosylases that partake in the first step of the base excision repair (BER) pathway. NEIL1 recognizes and cleaves mainly oxidized pyrimidines from DNA. The past decade has witnessed the ident
Externí odkaz:
https://doaj.org/article/dee331c6116d4f049473f3c07f4df23b
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009791 (2021)
PLoS Genetics, Vol 17, Iss 9, p e1009791 (2021)
Spore-forming pathogens like Clostridioides difficile depend on germination to initiate infection. During gemination, spores must degrade their cortex layer, which is a thick, protective layer of modified peptidoglycan. Cortex degradation depends on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c36a5f6568b65e724329bab72715604
http://europepmc.org/articles/PMC8496864
http://europepmc.org/articles/PMC8496864
Spore-forming pathogens like Clostridioides difficile depend on germination to initiate infection. Spore germination depends on the degradation of the protective spore peptidoglycan layer known as the spore cortex. Cortex degradation is mediated by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2b0e69fd8bef661eaacf4b0e029ff2
https://doi.org/10.1101/2021.06.21.449279
https://doi.org/10.1101/2021.06.21.449279
Autor:
Ashley Sjolund, Antonia A Nemec, Nicolas Paquet, Aishwarya Prakash, Patrick Sung, Sylvie Doublié, Joann B Sweasy
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004753 (2014)
Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG preferentially catalyzes the removal of thymine and uracil paired with gua
Externí odkaz:
https://doaj.org/article/93139c9ef2e74d0eb55e6d9ef8a8044f