From Molecular to Nanotechnology Strategies for Delivery of Neurotrophins: Emphasis on Brain-Derived Neurotrophic Factor (BDNF)

Autor: Claire Géral, Angelina Angelova, Sylviane Lesieur

Publikováno v: Pharmaceutics, Vol 5, Iss 1, Pp 127-167 (2013)

Neurodegenerative diseases represent a major public health problem, but beneficial clinical treatment with neurotrophic factors has not been established yet. The therapeutic use of neurotrophins has been restrained by their instability and rapid degr

Externí odkaz: https://doaj.org/article/478163ee33f04f639e2376afed6a9797

Critical steps during the prilling process of molten lipids: Main stumbling blocks due to pharmaceutical excipient properties

Autor: F. Séquier, M. Renouard, Vincent Faivre, Georges Daste, Sylviane Lesieur, J.-Y. Lanne

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2020, 576, pp.119036. ⟨10.1016/j.ijpharm.2020.119036⟩
International Journal of Pharmaceutics, Elsevier, 2020, 576, ⟨10.1016/j.ijpharm.2020.119036⟩

International audience; Prilling by ultrasonic jet break-up is an efficient process to produce perfectly spherical microparticles homogeneous in size. However, the material properties could affect the manufacturability and the final product propertie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af4763a0002789dbc48bded8b104dc8
https://hal.archives-ouvertes.fr/hal-03010647

Mesoporous self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances

Autor: Leïla Zerkoune, Sylviane Lesieur, Luc Choisnard, Angelina Angelova, Corinne Vebert-Nardin, Jean-Luc Putaux, Denis Wouessidjewe, Borislav Angelov, James Doutch, Annabelle Gèze

Publikováno v: Soft Matter
Soft Matter, Royal Society of Chemistry, 2016, 12 (36), pp.7539--7550. ⟨10.1039/c6sm00661b⟩

International audience; Soft mesoporous hierarchically structured particles were created by the self-assembly of an amphiphilic deep cavitand cyclodextrin βCD-nC10 (degree of substitution n = 7.3), with a nanocavity grafted by multiple alkyl (C10) c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34919e70e601e40c1deff6e5e6f4847
https://doi.org/10.1039/c6sm00661b

A scalable process to produce lipid-based compartmented Janus nanoparticles with pharmaceutically approved excipients

Autor: Ghislaine Frebourg, Vincent Faivre, Heinz Amenitsch, Sylviane Lesieur, Le Tuyet Chau Tran, Elodie Millart, Tri Truong-Cong

Publikováno v: Nanoscale
Nanoscale, Royal Society of Chemistry, 2018, 10 (8), pp.3654-3662. ⟨10.1039/C7NR08488A⟩

International audience; In the field of nanotechnologies, theranostic approaches and fixed-dose combination products require the development of innovative carriers able to co-encapsulate several entities of interest. This communication describes the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839f72fd08980dabdc62c79a8c8cbf6a
https://hal.archives-ouvertes.fr/hal-02368544

Biocompatible Mesoporous and Soft Nanoarchitectures

Autor: Rada Mutafchieva, Borislav Angelov, Sylviane Lesieur, Angelina Angelova

Publikováno v: Journal of Inorganic and Organometallic Polymers and Materials. 25:214-232

Soft nanoarchitectures created by biomimetic self-assembly offer unexploited potential for therapeutic drug delivery applications, tissue engineering, and diagnostics. The lipid bilayer building blocks impart biocompatible properties and low toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3373ac7b9ecf16091892fa8b4ca8c79
https://doi.org/10.1007/s10904-014-0143-8