Výsledky vyhledávání - "Sylviane Dewaele"

Akademický článek

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Autor: Tineke Vanderhaeghen, Steven Timmermans, Melanie Eggermont, Deepika Watts, Jolien Vandewalle, Charlotte Wallaeys, Louise Nuyttens, Joyca De Temmerman, Tino Hochepied, Sylviane Dewaele, Joke Vanden Berghe, Niek Sanders, Ben Wielockx, Rudi Beyaert, Claude Libert

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionPolymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and gluconeogenic amino acids. Since hepatic pero

Externí odkaz: https://doaj.org/article/d4cf3b606e8c4e34ae118f7e43e47016

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Akademický článek

Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 10, Pp 1-21 (2020)

Abstract The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF‐induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete pr

Externí odkaz: https://doaj.org/article/3e993b5bbeaf4e78b2bc46c529806814

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Akademický článek

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Autor: Lise Van Wyngene, Tineke Vanderhaeghen, Ioanna Petta, Steven Timmermans, Katrien Corbeels, Bart Van der Schueren, Jolien Vandewalle, Kelly Van Looveren, Charlotte Wallaeys, Melanie Eggermont, Sylviane Dewaele, Leen Catrysse, Geert van Loo, Rudi Beyaert, Roman Vangoitsenhoven, Toshinori Nakayama, Jan Tavernier, Karolien De Bosscher, Claude Libert

Publikováno v: iScience, Vol 24, Iss 7, Pp 102790- (2021)

Summary: The hypothalamic-pituitary-adrenal (HPA) axis forms a complex neuroendocrine system that regulates the body’s response to stress such as starvation. In contrast with the glucocorticoid receptor (GR), Zinc finger and BTB domain containing 3

Externí odkaz: https://doaj.org/article/3a3b104cdfd748ce878d5705d4550412

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Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

Publikováno v: Vandewalle, J, Timmermans, S, Paakinaho, V, Vancraeynest, L, Dewyse, L, Vanderhaeghen, T, Wallaeys, C, Van Wyngene, L, Van Looveren, K, Nuyttens, L, Eggermont, M, Dewaele, S, Velho, T R, Moita, L F, Weis, S, Sponholz, C, van Grunsven, L A, Dewerchin, M, Carmeliet, P, De Bosscher, K, Van de Voorde, J, Palvimo, J J & Libert, C 2021, ' Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis ', Cell Metabolism, vol. 33, no. 9, pp. 1763-1776.e5 . https://doi.org/10.1016/j.cmet.2021.07.002
Cell Metab

Sepsis is a potentially lethal syndrome resulting from a maladaptive response to infection. Upon infection, glucocorticoids are produced as a part of the compensatory response to tolerate sepsis. This tolerance is, however, mitigated in sepsis due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38228402ba76a0f86ea49079c3930fe
https://pure.au.dk/portal/da/publications/combined-glucocorticoid-resistance-and-hyperlactatemia-contributes-to-lethal-shock-in-sepsis(f288886d-cb0b-49b2-b8fb-df3cb0399dd4).html

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Akademický článek

N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters.

Autor: Roberto Testa, Valerie Vanhooren, Anna Rita Bonfigli, Massimo Boemi, Fabiola Olivieri, Antonio Ceriello, Stefano Genovese, Liana Spazzafumo, Vincenzo Borelli, Maria Giulia Bacalini, Stefano Salvioli, Paolo Garagnani, Sylviane Dewaele, Claude Libert, Claudio Franceschi

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119983 (2015)

Glycosylation, i.e the enzymatic addition of oligosaccharides (or glycans) to proteins and lipids, known as glycosylation, is one of the most common co-/posttranslational modifications of proteins. Many important biological roles of glycoproteins are

Externí odkaz: https://doaj.org/article/e5a05f60b170468dacde5aa11d6a9342

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Akademický článek

Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis.

Autor: Valerie Vanhooren, Roosmarijn E Vandenbroucke, Sylviane Dewaele, Evelien Van Hamme, Jody J Haigh, Tino Hochepied, Claude Libert

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e79883 (2013)

Glycosylation is an essential post-translational modification, which determines the function of proteins and important processes such as inflammation. β-1,4-galactosyltransferase I (βGalT1) is a key enzyme involved in the addition of galactose moie

Externí odkaz: https://doaj.org/article/8200ea6930334cd8902d314e06824299

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TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Autor: Sofie Vandevyver, Steven Timmermans, Jorma J. Palvimo, Karen Dendoncker, Jolien Souffriau, Lise Van Wyngene, Melanie Eggermont, Joanna K. Lempiäinen, Ville Paakinaho, Tineke Vanderhaeghen, Claude Libert, Karolien De Bosscher, Marlies Ballegeer, Marc Van Montagu, Evelien Van Hamme, Sylviane Dewaele, Rudi Beyaert, Kelly Van Looveren, Jolien Vandewalle

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 116(26)

Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the glucocorticoid receptor (GR). It is a problem in the management of infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f01b18ac48b77c9185ee3ba73c34b31
https://pubmed.ncbi.nlm.nih.gov/31332009

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ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Autor: Geert van Loo, Rudi Beyaert, Kelly Van Looveren, Roman Vangoitsenhoven, Tineke Vanderhaeghen, Bart Van der Schueren, Jan Tavernier, Toshinori Nakayama, Sylviane Dewaele, Charlotte Wallaeys, Steven Timmermans, Claude Libert, Leen Catrysse, Lise Van Wyngene, Melanie Eggermont, Ioanna Petta, Katrien Corbeels, Jolien Vandewalle, Karolien De Bosscher

Publikováno v: iScience, Vol 24, Iss 7, Pp 102790-(2021)
ISCIENCE
iScience

Summary The hypothalamic-pituitary-adrenal (HPA) axis forms a complex neuroendocrine system that regulates the body’s response to stress such as starvation. In contrast with the glucocorticoid receptor (GR), Zinc finger and BTB domain containing 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f4abb6980040acabb8f8da9ed8067c
https://doi.org/10.1016/j.isci.2021.102790

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Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8

Autor: Sophie Steeland, Paco Hulpiau, Elien Van Wonterghem, Jeroen Aerts, Griet Van Imschoot, Yvan Saeys, Jurgen Haustraete, Sylviane Dewaele, Claude Libert, Delphine Demeestere, Christoph Becker-Pauly, Nick Devoogdt, Rielana Wichert, Eline Dejonckheere, Lutgarde Arckens, Roosmarijn E. Vandenbroucke

Publikováno v: Molecular Therapy. 24:890-902

A detrimental role for matrix metalloproteinase 8 (MMP8) has been identified in several pathological conditions, e.g., lethal hepatitis and the systemic inflammatory response syndrome. Since matrix MMP8-deficient mice are protected in the above-menti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4c111763750e88c1fb00c5799d9645
https://doi.org/10.1038/mt.2016.2

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