Výsledky vyhledávání - "Sylvia Y M, Yao"

Akademický článek

Human concentrative nucleoside transporter 3 transfection with ultrasound and microbubbles in nucleoside transport deficient HEK293 cells greatly increases gemcitabine uptake.

Autor: Robert J Paproski, Sylvia Y M Yao, Nicole Favis, David Evans, James D Young, Carol E Cass, Roger J Zemp

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56423 (2013)

Gemcitabine is a hydrophilic clinical anticancer drug that requires nucleoside transporters to cross plasma membranes and enter cells. Pancreatic adenocarcinomas with low levels of nucleoside transporters are generally resistant to gemcitabine and ar

Externí odkaz: https://doaj.org/article/82517bf8aa514ea498cbf14dd0559750

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Role of cysteine 416 in

Autor: Sylvia Y M, Yao, Amy M L, Ng, Carol E, Cass, James D, Young

Publikováno v: The Biochemical journal. 475(20)

Human equilibrative nucleoside transporter 1 (hENT1), the first identified member of the ENT family of integral membrane proteins, is the primary mechanism for cellular uptake of physiologic nucleosides and many antineoplastic and antiviral nucleosid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fd9f7616fa3d610f50794436c819c14
https://pubmed.ncbi.nlm.nih.gov/30254099

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SLC28 and SLC29

Autor: Sylvia Y. M. Yao, James D. Young

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0bf0fb2062b482b14ae91def41b2fd2
https://doi.org/10.1007/978-3-319-67199-4_101838

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SLC28 and SLC29

Autor: Sylvia Y. M. Yao, James D. Young

Publikováno v: Encyclopedia of Signaling Molecules ISBN: 9781461464389

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdb013379eb87a8407052c92bc4642b3
https://doi.org/10.1007/978-1-4614-6438-9_101838-1

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Identification of Cys140 in helix 4 as an exofacial cysteine residue within the substrate-translocation channel of rat equilibrative nitrobenzylthioinosine (NBMPR)-insensitive nucleoside transporter rENT2

Autor: Sylvia Y. M. YAO, Manickavasagam SUNDARAM, Eugene G. CHOMEY, Carol E. CASS, Stephen A. BALDWIN, James D. YOUNG

Publikováno v: Biochemical Journal. 353:387-393

The human and rat equilibrative nucleoside transporter proteins hENT1, rENT1, hENT2 and rENT2 belong to a family of integral membrane proteins with 11 potential transmembrane segments (TMs), and are distinguished functionally by differences in transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e59312324b65e78c5f36a49b67c34045
https://doi.org/10.1042/bj3530387

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Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced inXenopusoocytes

Autor: null Sylvia Y. M. Yao, Amy M. L. Ng, Man

Publikováno v: Molecular Membrane Biology. 18:161-167

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::307ff4a71c3f59f949079361fc2ef9b8
https://doi.org/10.1080/09687680118681

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Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy

Autor: Marie D. PARKER, Ralph J. HYDE, Sylvia Y. M. YAO, Louisa MCROBERT, Carol E. CASS, James D. YOUNG, Glenn A. MCCONKEY, Stephen A. BALDWIN

Publikováno v: Biochemical Journal. 349:67-75

Plasmodium, the aetiologic agent of malaria, cannot synthesize purines de novo, and hence depends upon salvage from the host. Here we describe the molecular cloning and functional expression in Xenopus oocytes of the first purine transporter to be id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7312280eddb66b8e268f43d4aee96f12
https://doi.org/10.1042/bj3490067

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Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation

Autor: Sylvia Y M, Yao, Amy M L, Ng, Mark F, Vickers, Manickavasagam, Sundaram, Carol E, Cass, Stephen A, Baldwin, James D, Young

Publikováno v: The Journal of biological chemistry. 277(28)

The human (h) and rat (r) equilibrative (Na(+)-independent) nucleoside transporters (ENTs) hENT1, rENT1, hENT2, and rENT2 belong to a family of integral membrane proteins with 11 transmembrane domains (TMs) and are distinguished functionally by diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1068cfdb9fdf9db21a9fe68975118b9e
https://pubmed.ncbi.nlm.nih.gov/12006583

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Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)

Autor: Mabel W. L. Ritzel, Amy M. L. Ng, Sylvia Y. M. Yao, Kathryn Graham, Shaun K. Loewen, Kyla M. Smith, Ralph J. Hyde, Edward Karpinski, Carol E. Cass, Stephen A. Baldwin, James D. Young

Publikováno v: Molecular membrane biology. 18(1)

The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1 and hCNT2, found primarily in specialized epithelia, are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively. Both have orth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff56961c360209209bdccdedf7a7db1
https://pubmed.ncbi.nlm.nih.gov/11396613

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