Výsledky vyhledávání - "Sylvia Van Dorpe"

Akademický článek

Reversed-phase fused-core HPLC modeling of peptides

Autor: Matthias D'Hondt, Bert Gevaert, Sofie Stalmans, Sylvia Van Dorpe, Evelien Wynendaele, Kathelijne Peremans, Christian Burvenich, Bart De Spiegeleer

Publikováno v: Journal of Pharmaceutical Analysis, Vol 3, Iss 2, Pp 93-101 (2013)

Different fused-core stationary phase chemistries (C18, Amide, Phenyl-hexyl and Peptide ES-C18) were used for the analysis of 21 structurally representative model peptides. In addition, the effects of the mobile phase composition (ACN or MeOH as orga

Externí odkaz: https://doaj.org/article/dcc22d0b15fd4cb798023172dd993001

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Variation of the Net Charge, Lipophilicity, and Side Chain Flexibility in Dmt1-DALDA: Effect on Opioid Activity and Biodistribution

Autor: Sofie Stalmans, Steven Ballet, Carole Lemieux, Dirk Tourwé, Nathalie Bracke, Mariana Spetea, Mark E. Cooper, Peter W. Schiller, Bart De Spiegeleer, Evelien Wynendaele, Sylvia Van Dorpe, Johannes Zuegg, Cecilia Betti, Alexandre Novoa, Nga N. Chung

Publikováno v: Journal of Medicinal Chemistry. 55:9549-9561

The influence of the side chain charges of the second and fourth amino acid residues in the peptidic mu opioid lead agonist Dmt-D-Arg-Phe-Lys-NH2. ([Dmt(1)-DALDA) was examined. Additionally, to increase the overall lipophilicity of [Dmt(1)]-DALDA and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f81ee53381e5e00aee9c3099f9d38e
https://doi.org/10.1021/jm3008079

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Api88 Is a Novel Antibacterial Designer Peptide To Treat Systemic Infections with Multidrug-Resistant Gram-Negative Pathogens

Autor: Nicole Herth, Uwe Müller, Oliver Nolte, Daniel Knappe, Patricia Czihal, Ralf Hoffmann, Nicole Berthold, Bart De Spiegeleer, Stefania Piantavigna, Sylvia Van Dorpe, Norbert Sträter, Lisandra L. Martin, Gottfried Alber, Stefanie Fritsche, Michael Zahn, Annegret Binas, Gabriele Köhler

Publikováno v: ACS Chemical Biology. 7:1281-1291

The emergence of multiple-drug-resistant (MDR) bacterial pathogens in hospitals (nosocomial infections) presents a global threat of growing importance, especially for Gram-negative bacteria with extended spectrum β-lactamase (ESBL) or the novel New

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aed3f32363fd8d388284fbaacf378b8
https://doi.org/10.1021/cb300063v

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The Influence of Morphine on Cerebral 5-HT2A Availability in Dogs: a SPECT Study

Autor: Ingeborgh Polis, Bart De Spiegeleer, Jos Eersels, Kathelijne Peremans, Luc Duchateau, Antita Adriaens, Sylvia Van Dorpe, Stanislas Sys, Tim Waelbers, Simon Vermeire

Publikováno v: Journal of Nuclear Medicine, 53(12), 1969-1973. Society of Nuclear Medicine Inc.
Adriaens, A M, Polis, I E, Vermeire, S T, Waelbers, T, Duchateau, L, Sys, S U, Van Dorpe, S, Eersels, J L H, De Spiegeleer, B & Peremans, K 2012, ' The Influence of Morphine on Cerebral 5-HT2A Availability in Dogs: a SPECT Study ', Journal of Nuclear Medicine, vol. 53, no. 12, pp. 1969-1973 . https://doi.org/10.2967/jnumed.112.103796

UNLABELLED: The opioid and serotonergic systems are closely involved in pain processing and mood disorders. The aim of this study was to assess the influence of systemic morphine on cerebral serotonin 2A receptor (5-HT(2A)) binding in dogs using SPEC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eadb716688ae785fee2a8731bd41f60
https://doi.org/10.2967/jnumed.112.103796

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Desirability function combining metabolic stability and functionality of peptides

Autor: Kathelijne Peremans, Simon Vermeire, Antita Adriaens, Sylvia Van Dorpe, Ingeborgh Polis, Bart De Spiegeleer

Publikováno v: Journal of Peptide Science. 17:398-404

The evaluation of peptides as potential therapeutic or diagnostic agents requires the consideration of several criteria that are targeted around two axes: functionality and metabolic stability. Most often, a compromise has to be made between these mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3de1adc338962c3c1eddc407461fa25f
https://doi.org/10.1002/psc.1323

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Poster presentations

Autor: Stanislas Sys, Tim Waelbers, Jos Eersels, Bart De Spiegeleer, Kathelijne Peremans, André Dobbeleir, Kurt Audenaert, Luc Duchateau, Ingeborgh Polis, Simon Vermeire, Antita Adriaens, Sylvia Van Dorpe

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 37:333-481

canine frontal cortex. A. Adriaens, S. Vermeire, T. Waelbers, L. Duchateau, S. Sys, S. Van Dorpe, J. Eersels, A.Dobbeleir, B. De Spiegeleer, K. Audenaert, I. Polis, K. Peremans Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium; Dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d19bc192967dd2c152f5e6bb12e7fe1f
https://doi.org/10.1007/s00259-010-1559-1

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Hydrophilic interaction LC of peptides: Columns comparison and clustering

Autor: Bart De Spiegeleer, Kathelijne Peremans, Adel Pezeshki, Sylvia Van Dorpe, Christian Burvenich, Valentijn Vergote

Publikováno v: Journal of Separation Science. 33:728-739

A wide variety of hydrophilic interaction chromatography (HILIC) stationary phase surface chemistries are currently available. Although their selectivity can be considerably different, column comparison or clustering using peptides is limited. In thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8a805183fb191513f5ce2fa77eccda
https://doi.org/10.1002/jssc.200900476

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Development of peptide receptor binding assays: Methods to avoid false negatives

Autor: Bart De Spiegeleer, Christophe Van de Wiele, Christian Burvenich, Valentijn Vergote, Mathieu Verbeken, William A. Banks, Sylvia Van Dorpe

Publikováno v: Regulatory Peptides. 158:97-102

Selection of appropriate ligand receptor binding assay conditions is critical for peptides, where the possibility of obtaining false negative results is pertinent due to their inherent adsorption and instability characteristics, as well as high respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6373e90accbf83f8e1ef2c6d73d8ec8
https://doi.org/10.1016/j.regpep.2009.08.006

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Adsorption of peptides at the sample drying step: Influence of solvent evaporation technique, vial material and solution additive

Autor: Christian Burvenich, Alexander Popkov, Valentijn Vergote, Bart De Spiegeleer, Adel Pezeshki, Bram Baert, Sylvia Van Dorpe

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 49:607-612

Although the efficient and careful removal of solvent from samples by centrifugal evaporation or freeze-drying methods is an important step in peptidomics, the recovery of peptides has not yet been fully investigated with these sample drying methods.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16e3bc406a0ce6976b467bb0e5e196c
https://doi.org/10.1016/j.jpba.2008.12.003

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In vitro metabolic stability of obestatin: Kinetics and identification of cleavage products

Autor: Valentijn Vergote, Christian Burvenich, Sylvia Van Dorpe, Kathelijne Peremans, Bart De Spiegeleer

Publikováno v: Peptides. 29:1740-1748

The in vitro metabolic stability testing on synthetic obestatin peptides from two different species (human hOb and mouse mOb) using HPLC analysis is described. A reversed-phase C 18 column of 300 A pore size was used, with a gradient system based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebdc0bce3aae37fb97d6f96ff8ca31f
https://doi.org/10.1016/j.peptides.2008.05.018

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