Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study

Autor: Sharon Hulme, Andy Vail, Hiren C. Patel, Karen J. Illingworth, Nikolaos Tzerakis, Kayode Ogungbenro, James Galea, Andrew T. King, Pippa J. Tyrrell, Stephen J. Hopkins, Margaret E. Hoadley, Catherine McMahon, Sylvia Scarth, Nancy J. Rothwell

Publikováno v: Galea, J, Ogungbenro, K, Hulme, S, Patel, H, Scarth, S, Hoadley, M, Illingworth, K, McMahon, C J, Tzerakis, N, King, A T, Vail, A, Hopkins, S J, Rothwell, N & Tyrrell, P 2017, ' Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage : results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study ', Journal of neurosurgery, vol. 128, no. 2, pp. 515-523 . https://doi.org/10.3171/2016.9.JNS16615

OBJECTIVEAneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular event with long-term morbidity and mortality. Patients who survive the initial bleeding are likely to suffer further early brain injury arising from a plethora of pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314dad69963991b36137d3413fe08632
https://pubmed.ncbi.nlm.nih.gov/28298024

Variability of bacterial translocation in the absence of intestinal mucosal damage following injury and the influence of interleukin-6

Autor: Stephen J. Hopkins, Sylvia Scarth, Hirobumi Gunji, Geoffrey Warhurst, Rodney A. Little, Gordon L Carlson

Publikováno v: Pathophysiology. 13:39-49

Bacterial translocation and intestinal mucosal damage have been reported as potentially clinically important sequelae of injury. Evidence that endogenous interleukin-6 (IL-6) is able to protect against infection, and that orally administered IL-6 cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa18446155b1950accd232c8a89d2479
https://doi.org/10.1016/j.pathophys.2005.07.002

Reconstituting National Institute for Biological Standards and Control (NIBSC) chemokines

Autor: Sylvia Scarth, Margaret E. Hoadley, Stephen J. Hopkins

Publikováno v: Cytokine. 58(2)

We observed significant discrepancies between immunoassay results when using different internally prepared reference preparations for interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) from the National Institute for Biological Stand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f89d77d1610711ed7b8887f0ca6d53
https://pubmed.ncbi.nlm.nih.gov/22364913

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production

Autor: Nancy J. Rothwell, Karen J. Illingworth, Carole M. Gavin, Elisa M. Barberan, Hedley C. A. Emsley, Andy Vail, Vijitha Wickramasinghe, Stephen J. Hopkins, Rachel Georgiou, Margaret E. Hoadley, Sylvia Scarth, Pippa J. Tyrrell, Craig J. Smith

Publikováno v: BMC Neurology
BMC Neurology, Vol 7, Iss 1, p 5 (2007)

Background As critical mediators of local and systemic inflammatory responses, cytokines are produced in the brain following ischaemic stroke. Some have been detected in the circulation of stroke patients, but their role and source is unclear. Focusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc96ba8c94d52b0a8efa719c5818fe9
http://livrepository.liverpool.ac.uk/722/1/722.pdf

1484 Penetration of interleukin-1 receptor antagonist into the cerebrospinal fluid of patients with subarachnoid haemorrhage

Autor: Nancy J. Rothwell, Sylvia Scarth, Pippa J. Tyrrell, Stephen J. Hopkins, Catherine McMahon, A King, Simon R Clark

Publikováno v: Journal of the Neurological Sciences. 238:S478

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6703c7ef903726ebdef979ab39f013bf
https://doi.org/10.1016/s0022-510x(05)81844-1