Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1

Autor: Sylvia Nieuwenhuis, Kees Okkersen, Joanna Widomska, Paul Blom, Peter A. C. 't Hoen, Baziel van Engelen, Jeffrey C. Glennon

Publikováno v: Frontiers in Neurology, Vol 10 (2019)

Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease characterized by multi-system involvement. Affected organ system includes skeletal muscle, heart, gastro-intestinal system and the brain. In this review, we evaluate the evidenc

Externí odkaz: https://doaj.org/article/75452f87c1a741b89d935c5864036dce

Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy.

Autor: Magda S C Fontes, Antonia J A Raaijmakers, Tessa van Doorn, Bart Kok, Sylvia Nieuwenhuis, Roel van der Nagel, Marc A Vos, Teun P de Boer, Harold V M van Rijen, Marti F A Bierhuizen

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87226 (2014)

In mice, the calcium-dependent phosphatase calcineurin A (CnA) induces a transcriptional pathway leading to pathological cardiac hypertrophy. Interestingly, induction of CnA has been frequently noticed in human hypertrophic and failing hearts. Indepe

Externí odkaz: https://doaj.org/article/d1a9d6de098e45ce88c602014dc5cba3

Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1

Autor: Paul Blom, Sylvia Nieuwenhuis, Jeffrey C. Glennon, Baziel G.M. van Engelen, Peter A C 't Hoen, Joanna Widomska, Kees Okkersen

Publikováno v: Frontiers in Neurology, 10
Frontiers in Neurology
Frontiers in Neurology, Vol 10 (2019)

Contains fulltext : 215262.pdf (Publisher’s version ) (Open Access) Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease characterized by multi-system involvement. Affected organ system includes skeletal muscle, heart, gastro-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5bdb55b20682e188f161ee362525c1
https://hdl.handle.net/2066/215262

Galectin-2 Induces a Proinflammatory, Anti-Arteriogenic Phenotype in Monocytes and Macrophages

Autor: Tineke C. T. M. van der Pouw Kraan, Anja M. van der Laan, Ruud D. Fontijn, Juan J. Garcia-Vallejo, Maurits R. Hollander, Daphne Y.S. Vogel, Christine D. Dijkstra, J.M. Baggen, Sylvia Nieuwenhuis, Cansu Yıldırım, Niels van Royen, Paul H.A. Quax, Anton J.G. Horrevoets, Anouk Haverkamp, Margreet R. de Vries

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124347 (2015)
Yildirim, C, Vogel, D Y S, Hollander, M R, Baggen, J M, Fontijn, R D, Nieuwenhuis, S, Haverkamp, A, de Vries, M R, Quax, P H A, Garcia Vallejo, J J, van der Laan, A M, Dijkstra, C D, van der Pouw-Kraan, T C T M, van Royen, N & Horrevoets, A J G 2015, ' Galectin-2 Induces a Proinflammatory, Anti-Arteriogenic Phenotype in Monocytes and Macrophages ', PLoS ONE, vol. 10, no. 4, e0124347 . https://doi.org/10.1371/journal.pone.0124347
PLoS ONE, 10(4):e0124347. Public Library of Science
PLoS ONE, 10(4). Public Library of Science
PLoS ONE

Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients. The inhibiting effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cd5abb8a4c055d2e85145ae5a2f7a1
https://doi.org/10.1371/journal.pone.0124347