Current advances in lipid and polymeric antimicrobial peptide delivery systems and coatings for the prevention and treatment of bacterial infections

Autor: Miriam E. van Gent, Peter H. Nibbering, Sylvia Natalie Kłodzińska, Muhanad Ali

Publikováno v: Pharmaceutics, 13(11). MDPI
Pharmaceutics, Vol 13, Iss 1840, p 1840 (2021)
Pharmaceutics
van Gent, M E, Ali, M, Nibbering, P H & Kłodzińska, S N 2021, ' Current advances in lipid and polymeric antimicrobial peptide delivery systems and coatings for the prevention and treatment of bacterial infections ', Pharmaceutics, vol. 13, no. 11, 1840 . https://doi.org/10.3390/pharmaceutics13111840

Bacterial infections constitute a threat to public health as antibiotics are becoming less effective due to the emergence of antimicrobial resistant strains and biofilm and persister formation. Antimicrobial peptides (AMPs) are considered excellent a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bc7a31a2ac65b5c68a0bedb32162c8
https://hdl.handle.net/1887/3247621

Inhalable Antimicrobials for Treatment of Bacterial Biofilm-Associated Sinusitis in Cystic Fibrosis Patients: Challenges and Drug Delivery Approaches

Autor: Sylvia Natalie Kłodzińska, Petra Alexandra Priemel, Thomas Rades, Hanne Mørck Nielsen

Publikováno v: International Journal of Molecular Sciences, Vol 17, Iss 10, p 1688 (2016)

Bacterial biofilm-associated chronic sinusitis in cystic fibrosis (CF) patients caused by Pseudomonas aeruginosa infections and the lack of available treatments for such infections constitute a critical aspect of CF disease management. Currently, inh

Externí odkaz: https://doaj.org/article/2691c5ca97124a258646b00307225bc0

Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

Autor: Knud J. Jensen, Mikkel B. Thygesen, Claus Sternberg, Hanne Mørck Nielsen, Søren S.-R. Bohr, Kasper K. Sørensen, Tommy Nylander, Zheng Huang, Nikos S. Hatzakis, Haidar Jumaa, Feng Wan, Sylvia Natalie Kłodzińska

Publikováno v: Wan, F, Bohr, S S-R, Kłodzińska, S N, Jumaa, H, Huang, Z, Nylander, T, Thygesen, M B, Sørensen, K K, Jensen, K J, Sternberg, C, Hatzakis, N & Mørck Nielsen, H 2020, ' Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs ', ACS Applied Materials and Interfaces, vol. 12, no. 1, pp. 380-389 . https://doi.org/10.1021/acsami.9b19644

Inhaled antibiotic treatment of cystic fibrosis-related bacterial biofilm infections is challenging due to the pathological environment of the lungs. Here, we present an "environment adaptive" nanoparticle composed of a solid poly lactic-co-glycolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39136087b21688538ca2913c27ca4dc4
https://orbit.dtu.dk/en/publications/43b7c99f-73d4-44e6-b9de-9d9f4afc1963

Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into

Autor: Feng, Wan, Søren S-R, Bohr, Sylvia Natalie, Kłodzińska, Haidar, Jumaa, Zheng, Huang, Tommy, Nylander, Mikkel Boas, Thygesen, Kasper Kildegaard, Sørensen, Knud Jørgen, Jensen, Claus, Sternberg, Nikos, Hatzakis, Hanne, Mørck Nielsen

Publikováno v: ACS applied materialsinterfaces. 12(1)

Inhaled antibiotic treatment of cystic fibrosis-related bacterial biofilm infections is challenging because of the pathological environment of the lungs. Here, we present an "environment-adaptive" nanoparticle composed of a solid poly lactic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1ddec4d3965707aca211fc2843cbf29
https://pubmed.ncbi.nlm.nih.gov/31804792

Utilizing nanoparticles for improving anti-biofilm effects of azithromycin: A head-to-head comparison of modified hyaluronic acid nanogels and coated poly (lactic-co-glycolic acid) nanoparticles

Autor: Haidar Jumaa, Thomas Rades, Hanne Mørck Nielsen, Feng Wan, Sylvia Natalie Kłodzińska, Claus Sternberg

Publikováno v: Journal of colloid and interface science. 555

Hypothesis The widespread resistance of bacteria to traditional antibiotic treatments has expedited the search for novel therapies against these pathogens. The hypothesis of this work is that two distinctively different polymeric delivery systems, sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52270d16eeaee9bc7032d7f85f1f0ed4
https://pubmed.ncbi.nlm.nih.gov/31404843