Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sylvia Merk"'
Autor:
Ute Fischer, Christian Ruckert, Bernd Hubner, Olaf Eckermann, Vera Binder, Tamam Bakchoul, Friedhelm R. Schuster, Sylvia Merk, Hans-Ulrich Klein, Monika Führer, Martin Dugas, Arndt Borkhardt
Publikováno v:
Haematologica, Vol 97, Iss 9 (2012)
Background Very severe aplastic anemia is characterized by a hypoplastic bone marrow due to destruction of CD34+ stem cells by autoreactive T cells. Investigation of the pathomechanism by patient-specific gene expression analysis of the attacked stem
Externí odkaz:
https://doaj.org/article/f00399b8fe6b4bb58aedf5218d8aa507
Autor:
Claudio Rodriguez Gonzalez, Débora Basílio-Queirós, Anna-Lena Neehus, Sylvia Merkert, David Tschritter, Sinem Ünal, Jan Hegermann, Matthias Mörgelin, Jacinta Bustamante, Manuel Manfred Nietert, Ulrich Martin, Burkhard Tümmler, Antje Munder, Nico Lachmann
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionCystic fibrosis (CF) is a hereditary autosomal recessive disease driven by deleterious variants of the CFTR gene, leading, among other symptoms, to increased lung infection susceptibility. Mucus accumulation in the CF lung is, as of yet,
Externí odkaz:
https://doaj.org/article/bdb3543dfdf94471a237858b78293635
Autor:
Holger Schwender, Martin Schäfer, Sylvia Merk, Claudia Haferlach, Martin Dugas, Katja Ickstadt
Motivation: The analysis of a number of different genetic features like copy number (CN) variation, gene expression (GE) or loss of heterocygosity has considerably increased in recent years, as well as the number of available datasets. This is partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8a5d8cf8af516b256f1deb849dc947
http://doc.rero.ch/record/291630/files/btp592.pdf
http://doc.rero.ch/record/291630/files/btp592.pdf
Autor:
Sylvia Merkert, Alexandra Haase, Julia Dahlmann, Gudrun Göhring, Fakhar H. Waqas, Frank Pessler, Ulrich Martin, Ruth Olmer
Publikováno v:
Stem Cell Research, Vol 69, Iss , Pp 103090- (2023)
The nuclear factor erythroid 2-related factor 2 (NFE2L2, known as NRF2) regulates the expression of antioxidative and anti-inflammatory proteins. In order to investigate its impact during viral infections and testing of antiviral compounds, we applie
Externí odkaz:
https://doaj.org/article/8e6814b4fbde47d2b87e5fb062e24452
Publikováno v:
Methods of Information in Medicine. 45:146-152
Summary Background: The development of diagnostic procedures based on microarray analysis confronts the bioinformatician and the biomedical researcher with a variety of challenges. Microarrays generate a huge amount of data. There are many, not yet c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4b221e6f51ec7d92c288e2e7321f71
https://doi.org/10.1055/s-0038-1634058
https://doi.org/10.1055/s-0038-1634058
Autor:
Ludwig Zwermann, Stefan Kääb, Andreas S. Barth, Martin Hinterseer, Gerhard Steinbeck, Sylvia Merk, Martin Dugas, Patrick Kloos, Eckart Kreuzer, Michael Nabauer, Mathias Gebauer, Klaus Steinmeyer, Heike Kartmann, Markus Bleich, Elisabeth Arnoldi
Publikováno v:
Circulation Research. 96:1022-1029
Atrial fibrillation is associated with increased expression of ventricular myosin isoforms in atrial myocardium, regarded as part of a dedifferentiation process. Whether reexpression of ventricular isoforms in atrial fibrillation is restricted to tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f6bdf2cce639233757e93ad8cc96b8
https://doi.org/10.1161/01.res.0000165480.82737.33
https://doi.org/10.1161/01.res.0000165480.82737.33
Autor:
Arne Pfeufer, Stefan Kääb, Markus Bleich, Elisabeth Arnoldi, Andreas S. Barth, Ludwig Zwermann, Peter Überfuhr, Gerhard Steinbeck, Patrick Kloos, Klaus Steinmeyer, Martin Dugas, Mathias Gebauer, Michael Nabauer, Sylvia Merk
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 450:201-208
The purpose of our investigation was to identify the transcriptional basis for ultrastructural and functional specialization of human atria and ventricles. Using exploratory microarray analysis (Affymetrix U133A+B), we detected 11,740 transcripts exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45f3644137ea03fef1248345928f487
https://doi.org/10.1007/s00424-005-1404-8
https://doi.org/10.1007/s00424-005-1404-8
Autor:
Mathias Gebauer, Markus Bleich, Gerhard Steinbeck, Eckart Kreuzer, Arne Pfeufer, Stefan Kääb, Andreas S. Barth, Michael Nabauer, Ludwig Zwermann, Martin Dugas, Klaus Steinmeyer, Daniel Margerie, Sylvia Merk
Publikováno v:
Journal of Molecular Medicine. 82:308-316
To obtain region- and disease-specific transcription profiles of human myocardial tissue, we explored mRNA expression from all four chambers of eight explanted failing [idiopathic dilated cardiomyopathy (DCM), n=5; ischemic cardiomyopathy (ICM), n=3]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567130b9b3d5be415a181dd0c7c8b162
https://doi.org/10.1007/s00109-004-0527-2
https://doi.org/10.1007/s00109-004-0527-2
Publikováno v:
Bioinformatics. 20:931-936
Motivation: Unsupervised clustering of microarray data may detect potentially important, but not obvious characteristics of samples, for instance subgroups of diagnoses with distinct gene profiles or systematic errors in experimentation. Results: Mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5331587a457ab76752787f19dde492c3
https://doi.org/10.1093/bioinformatics/bth009
https://doi.org/10.1093/bioinformatics/bth009
Publikováno v:
International Journal of Hygiene and Environmental Health. 204:127-131
DNA from Burkholderia cepacia was prepared from suspensions of pure cultures and artificially contaminated waste water. The efficacy of four standard methods (lysis buffer containing proteinase K, phenol/chloroform/isoamylalcohol extraction, microwav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84328ea9c7c93ec88a1fe20fd3e105f
https://doi.org/10.1078/1438-4639-00083
https://doi.org/10.1078/1438-4639-00083