BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Autor: WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon, Giuseppina Tesco

Publikováno v: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2018)

Abstract Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients. Our previous

Externí odkaz: https://doaj.org/article/7258624d78f2453a9df25d037112256f

BACE1 partial deletion induces synaptic plasticity deficit in adult mice

Autor: WonHee Kim, Sylvia Lombardo, Giuseppina Tesco, Matthew E. Kennedy, Andrew J. Tarr, Thomas W. Rosahl, Philip G. Haydon, Tingyi Cao, Martina Chiacchiaretta, Griffin Sigal, Weiming Xia

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports

BACE1 is the first enzyme involved in APP processing, thus it is a strong therapeutic target candidate for Alzheimer’s disease. The observation of deleterious phenotypes in BACE1 Knock-out (KO) mouse models (germline and conditional) raised some co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d32bd984fe5d424c07d1710fab1c0c5
https://doi.org/10.1038/s41598-019-56329-7

A role for β2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus

Autor: Sylvia Lombardo, Morgane Besson, Uwe Maskos, Julie Catteau

Publikováno v: Neurobiology of Aging
Neurobiology of Aging, 2016, 46, pp.221-234. ⟨10.1016/j.neurobiolaging.2016.06.005⟩
Neurobiology of Aging, Elsevier, 2016, 46, pp.221-234. ⟨10.1016/j.neurobiolaging.2016.06.005⟩

International audience; Keywords: In vivo amyloid pathology Amyloid precursor protein a7 nicotinic receptor b2 nicotinic receptor Memory deficit Hippocampus a b s t r a c t Alzheimer's disease (AD) is characterized by the presence of plaques and tang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b14758adc479614c282062f20dfcf60
https://doi.org/10.1016/j.neurobiolaging.2016.06.005

List of Contributors

Autor: Ottavio Arancio, Nancy Bartolotti, Adam W. Bero, Jacqueline A. Bonds, Marcelo G. Bonini, Guojun Bu, Xu Chen, Toby Cumming, Jole Fiorito, Li Gan, David Gate, Walter Gulisano, Peter C. Hart, Jacob M. Haus, Katherine A. Jackman, Takahisa Kanekiyo, Orly Lazarov, Sylvia Lombardo, Robert A. Marr, Keri Martinowich, Eliezer Masliah, Alyson A. Miller, Richard D. Minshall, Russell Nicholls, Agostino Palmeri, Rosita Purgatorio, Daniela Puzzo, Amanda R. Rabinowitz, Meredith C. Reichert, David P. Salmon, Robert J. Schloesser, Douglas H. Smith, Giuseppina Tesco, Terrence Town, Li-Huei Tsai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f508e7bec2a61acbe6c081f6f466203b
https://doi.org/10.1016/b978-0-12-802851-3.00020-6

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment

Autor: Uwe Maskos, Sylvia Lombardo

Publikováno v: Neuropharmacology
Neuropharmacology, 2015, The Nicotinic Acetylcholine Receptor: From Molecular Biology to Cognition, 96 (Pt B), pp.255-62. ⟨10.1016/j.neuropharm.2014.11.018⟩
Neuropharmacology, Elsevier, 2015, The Nicotinic Acetylcholine Receptor: From Molecular Biology to Cognition, 96 (Pt B), pp.255-62. ⟨10.1016/j.neuropharm.2014.11.018⟩

International audience; Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of cholinergic tone, and acetylcholine (ACh) level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab51442e164f28cd059825162b2fe1f3
https://hal-pasteur.archives-ouvertes.fr/pasteur-01197130/document