Zobrazeno 1 - 10 of 49 pro vyhledávání: '"Sylvia Kaden"'
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Akademický článek
Blockade of Glycosphingolipid Synthesis Inhibits Cell Cycle and Spheroid Growth of Colon Cancer Cells In Vitro and Experimental Colon Cancer Incidence In Vivo
Autor: Richard Jennemann, Martina Volz, Felix Bestvater, Claudia Schmidt, Karsten Richter, Sylvia Kaden, Johannes Müthing, Hermann-Josef Gröne, Roger Sandhoff
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 19, p 10539 (2021)
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers in humans. At early stages CRC is treated by surgery and at advanced stages combined with chemotherapy. We examined here the potential effect of glucosylceramide synthase (GCS)-i
Externí odkaz: https://doaj.org/article/e51e86b8869d4369aa31a8c5b43f6613
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2
Structural expression of bovine milk and meat factors in tissues of colorectal, lung and pancreatic cancer patients
Autor: Ekaterina Nikitina, Kristina Alikhanyan, Michelle Neßling, Karsten Richter, Sylvia Kaden, Claudia Ernst, Stefan Seitz, Liubov Chuprikova, Lisa Häfele, Karin Gunst, Nuh Rahbari, Emrullah Birgin, Erik Rasbach, Mohammad Rahbari, Alexander Brobeil, Miriam Schenk, Markus Büchler, Ethel‐Michele de Villiers, Timo Bund, Harald zur Hausen
Publikováno v: International journal of cancerREFERENCES.
Chronic inflammation, linked to the presence of bovine milk and meat factors (BMMFs) and specific subsets of macrophages, results in oxygen radical synthesis and induction of mutations in DNA of actively replicating cells and replicating single stran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100fba72cbb23955363be3dca4b44c33
https://pubmed.ncbi.nlm.nih.gov/36444499
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3
Gangliosides modulate insulin secretion by pancreatic beta cells under glucose stress
Autor: Hermann-Josef Gröne, Martina Volz, Silke Herzer, Richard Jennemann, Roger Sandhoff, Sylvia Kaden, Viola Nordström
Publikováno v: Glycobiology. 30:722-734
In pancreatic beta cells, the entry of glucose and downstream signaling for insulin release is regulated by the glucose transporter 2 (Glut2) in rodents. Dysfunction of the insulin-signaling cascade may lead to diabetes mellitus. Gangliosides, sialic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1a97884f89dfe3b2236bc95fb820d8
https://doi.org/10.1093/glycob/cwaa022
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4
Blockade of Glycosphingolipid Synthesis Inhibits Cell Cycle and Spheroid Growth of Colon Cancer Cells In Vitro and Experimental Colon Cancer Incidence In Vivo
Autor: Claudia Schmidt, Sylvia Kaden, Karsten Richter, Roger Sandhoff, Richard Jennemann, Felix Bestvater, Hermann-Josef Gröne, Martina Volz, Johannes Müthing
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10539, p 10539 (2021)
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers in humans. At early stages CRC is treated by surgery and at advanced stages combined with chemotherapy. We examined here the potential effect of glucosylceramide synthase (GCS)-i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1948257d9b3ebcd30b9c8bd00d97acfd
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5
Akademický článek
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
Autor: Viola Nordström, Monja Willershäuser, Silke Herzer, Jan Rozman, Oliver von Bohlen Und Halbach, Sascha Meldner, Ulrike Rothermel, Sylvia Kaden, Fabian C Roth, Clemens Waldeck, Norbert Gretz, Martin Hrabě de Angelis, Andreas Draguhn, Martin Klingenspor, Hermann-Josef Gröne, Richard Jennemann
Publikováno v: PLoS Biology, Vol 11, Iss 3, p e1001506 (2013)
Hypothalamic neurons are main regulators of energy homeostasis. Neuronal function essentially depends on plasma membrane-located gangliosides. The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expressi
Externí odkaz: https://doaj.org/article/6df52cc8e3e74af38026d85d326f2919
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6
Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation
Autor: Zoran B. Popović, Mahnaz Bonrouhi, Wolf D. Lehmann, Hermann Josef Gröne, Giuseppina Federico, Francesca Rampoldi, Sylvia Kaden, Stefan Porubsky, Fabian Brunk, Martin E. Boehm
Publikováno v: The Journal of Immunology. 195:4228-4243
N-myristoylation refers to the attachment of myristic acid to the N-terminal glycine of proteins and substantially affects their intracellular targeting and functions. The thymus represents an organ with a prominent N-myristoylation activity. To eluc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac64108c892586288e31a6c03adc139a
https://doi.org/10.4049/jimmunol.1500622
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7
Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism
Autor: Richard Jennemann, Daniel Mathow, Mariona Rabionet, Federica Chessa, Alexander Feuerborn, Hermann Josef Gröne, Roger Sandhoff, Sylvia Kaden
Publikováno v: EMBO reports. 16:321-331
This study proposes that the transcription factor Zeb1 modulates epithelial cell adhesion by diverting glycosphingolipid metabolism. Zeb1 promotes expression of a-series glycosphingolipids via regulating expression of GM3 synthase (St3gal5), which me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c414f71882b755e6a24223e2d8ffbb4
https://doi.org/10.15252/embr.201439333
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9
Glucocorticoid Activity during Lung Maturation Is Essential in Mesenchymal and Less in Alveolar Epithelial Cells
Autor: Günther Schütz, Hermann Josef Gröne, Daniel Habermehl, Felix Wieland, Sylvia Kaden, Britta Brügger, Jan Rodriguez Parkitna
Publikováno v: Molecular Endocrinology. 25:1280-1288
Corticosteroid treatment is an established therapy for preterm infants, and germline inactivation of the glucocorticoid receptor (GR) gene in the mouse leads to respiratory failure and postnatal lethality. Although glucocorticoids have been thought t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00a9b24e3ecb5ae9377b66f7121c9d6
https://doi.org/10.1210/me.2009-0380
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10
Iron Regulatory Proteins Secure Mitochondrial Iron Sufficiency and Function
Autor: Bruno Galy, Matthias W. Hentze, Sylvia Kaden, Hervé Puy, Hermann Josef Gröne, Sven W. Sauer, Said Lyoumi, Dunja Ferring-Appel, Stefan Kölker
Publikováno v: Cell Metabolism. 12:194-201
SummaryMitochondria supply cells with ATP, heme, and iron sulfur clusters (ISC), and mitochondrial energy metabolism involves both heme- and ISC-dependent enzymes. Here, we show that mitochondrial iron supply and function require iron regulatory prot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ff170bcb52b2c30b82bd267ed66662
https://doi.org/10.1016/j.cmet.2010.06.007
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