COVID-19 is associated with distinct myopathic features in the diaphragm of critically ill patients

Autor: Zhonghua Shi, Leo Heunks, Marianna Bugiani, Sylvia J P Bogaards, Stefan Conijn, Yeszamin Onderwater, Pedro Espinosa, Diewertje I Bink, Marloes van den Berg, Martijn van de Locht, Hans van der Hoeven, Reinier A Boon, Coen A C Ottenheijm

Publikováno v: BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)

Externí odkaz: https://doaj.org/article/bfc23ce2954c4e40bccc44b916851940

Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator

Autor: Sylvia J. P. Bogaards, Pleuni E. Hooijman, Leo M. A. Heunks, Coen A.C. Ottenheijm, Robbert van der Pijl, Stefan Conijn, Henk Granzier, Martijn van de Locht, Siegfried Labeit, Marloes van den Berg, Shengyi Shen, Paul R. Langlais

Publikováno v: The Journal of general physiology, 153(7):e202112925. Rockefeller University Press
van der Pijl, R J, van den Berg, M, van de Locht, M, Shen, S, Bogaards, S J P, Conijn, S, Langlais, P, Hooijman, P E, Labeit, S, Heunks, L M A, Granzier, H & Ottenheijm, C A C 2021, ' Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator ', The Journal of general physiology, vol. 153, no. 7, e202112925 . https://doi.org/10.1085/jgp.202112925
The Journal of General Physiology

Muscle ankyrin repeat protein 1 (MARP1) is frequently up-regulated in stressed muscle, but its effect on skeletal muscle function is poorly understood. Here, we focused on its interaction with the titin–N2A element, found in titin’s molecular spr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385a335b1322d4b7df487fdeb59713cd
https://research.vumc.nl/en/publications/b3dd729d-c32d-486c-9449-4f3dd5f2b4d6

KBTBD13 is an actin-binding protein that modulates muscle kinetics

Autor: Leonardo Nogara, Saskia Lassche, Jonne Doorduin, Norma B. Romero, Benno Küsters, Tamar E. Sztal, Baziel G.M. van Engelen, Balázs Kiss, Stefan Conijn, Josine M. de Winter, Coen A.C. Ottenheijm, Weikang Ma, Georg Ramm, Viola Oorschot, Joery P. Molenaar, Shengyi Shen, Christopher N. Johnson, Richard J. Rodenburg, Bert Blaauw, Robbert van der Pijl, Henk Granzier, Thomas E. Hall, Ken Campbell, Frank Li, Thomas C. Irving, Alan H. Beggs, Michaela Yuen, Reinier A. Boon, Manuela Marabita, Menne van Willigenburg, Esmee S.B. Van Kleef, Noelia Lozano-Vidal, Sylvia J. P. Bogaards, Robert J. Bryson-Richardson, Avnika A. Ruparelia, Dilson E. Rassier, Martijn van de Locht, Edoardo Malfatti, Malin Persson, Zherui Xiong, Nicol C. Voermans

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2020, 130 (2), pp.754-767. ⟨10.1172/JCI124000⟩
Journal of Clinical Investigation, 130, 2, pp. 754-767
J Clin Invest
Journal of Clinical Investigation, 130(2), 754-767. The American Society for Clinical Investigation
de Winter, J M, Molenaar, J P, Yuen, M, van der Pijl, R, Shen, S, Conijn, S, van de Locht, M, Willigenburg, M, Bogaards, S J P, van Kleef, E S, Lassche, S, Persson, M, Rassier, D E, Sztal, T E, Ruparelia, A A, Oorschot, V, Ramm, G, Hall, T E, Xiong, Z, Johnson, C N, Li, F, Kiss, B, Lozano-Vidal, N, Boon, R A, Marabita, M, Nogara, L, Blaauw, B, Rodenburg, R J, Küsters, B, Doorduin, J, Beggs, A H, Granzier, H, Campbell, K, Ma, W, Irving, T, Malfatti, E, Romero, N B, Bryson-Richardson, R J, van Engelen, B G M, Voermans, N C & Ottenheijm, C A C 2020, ' KBTBD13 is an actin-binding protein that modulates muscle kinetics ', Journal of Clinical Investigation, vol. 130, no. 2, pp. 754-767 . https://doi.org/10.1172/JCI124000
Journal of clinical investigation, 130(2), 754-767. The American Society for Clinical Investigation
Journal of Clinical Investigation, 130, 754-767

International audience; The mechanisms that modulate the kinetics of muscle relaxation are critically important for muscle function. A prime example of the impact of impaired relaxation kinetics is nemaline myopathy caused by mutations in KBTBD13 (NE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8814b2daabcdfb84373f75468712d908
http://hdl.handle.net/11577/3321703

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

Autor: Johan Lindqvist, Leo M. A. Heunks, Henk Granzier, René J. P. Musters, Shengyi Shen, Marloes van den Berg, Sylvia J. P. Bogaards, Judith Elshof, Armand R. J. Girbes, Joshua Strom, Zhong Hua Shi, Angelique M. E. Spoelstra-de Man, Jeroen Kole, Albertus Beishuizen, Monique C. de Waard, Marinus A. Paul, Robbert van der Pijl, Charissa E. van den Brom, Pleuni E. Hooijman, Coen A.C. Ottenheijm

Publikováno v: Lindqvist, J, van den Berg, M, van der Pijl, R, Hooijman, P E, Beishuizen, A, Elshof, J, de Waard, M, Girbes, A, Spoelstra-de Man, A, Shi, Z-H, van den Brom, C, Bogaards, S, Shen, S, Strom, J, Granzier, H, Kole, J, Musters, R J P, Paul, M A, Heunks, L M A & Ottenheijm, C A C 2018, ' Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers ', American Journal of Respiratory and Critical Care Medicine, vol. 198, no. 4, pp. 472-485 . https://doi.org/10.1164/rccm.201709-1917OC
American Journal of Respiratory and Critical Care Medicine, 198(4), 472-485. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine

RATIONALE: Diaphragm weakness in critically ill patients prolongs ventilator dependency and duration of hospital stay, and increases mortality and health care costs. The mechanisms underlying diaphragm weakness include cross-sectional fiber atrophy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515e5c18b2120253f18c56df77be93ca
https://research.vumc.nl/en/publications/f4c772cd-7718-417c-9fad-515ba6e57aff

Ultrasound and Microbubble-Induced Local Delivery of MicroRNA-Based Therapeutics

Autor: René J. P. Musters, Zhiyong Lei, Walter Paulus, Sylvia J. P. Bogaards, Otto Kamp, Rick F. J. Kwekkeboom, Joost P.G. Sluijter, Eric Aiazian

Publikováno v: Kwekkeboom, R F J, Lei, Z Y, Bogaards, S J P, Aiazian, E, Kamp, O, Paulus, W J, Sluijter, J P G & Musters, R J P 2015, ' Ultrasound and Microbubble-Induced Local Delivery of Microrna-Based Therapeutics ', Ultrasound in Medicine and Biology, vol. 41, no. 1, pp. 163-176 . https://doi.org/10.1016/j.ultrasmedbio.2014.08.012
Ultrasound in Medicine and Biology, 41(1), 163. Elsevier USA
Ultrasound in Medicine and Biology, 41(1), 163-176. Elsevier USA

MicroRNAs are involved in many pathologic processes and are a promising target for therapeutic intervention. However, successful, localized delivery of microRNA-based therapeutics is lacking. In this study, cationic ultrasound-responsive microbubbles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cba12b9be2f3c11556a98ae6e332ddd
https://doi.org/10.1016/j.ultrasmedbio.2014.08.012