Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Sylvia F Boj"'
Autor:
Onno Kranenburg, Hergen Spits, Julien Villaudy, Madalina Cercel, Miriam Koopman, Cornelis J A Punt, Jamila Laoukili, Andre Verheem, Inne H M Borel Rinkes, Emre Küçükköse, Balthasar A Heesters, Susan van Hal, Sylvia F Boj, Jeanine M L Roodhart
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background The immunogenic nature of metastatic colorectal cancer (CRC) with high microsatellite instability (MSI-H) underlies their responsiveness to immune checkpoint blockade (ICB). However, resistance to ICB is commonly observed, and is associate
Externí odkaz:
https://doaj.org/article/bfcad88f61be41c09cf923011ef6cf7d
Autor:
Elisa De Crignis, Tanvir Hossain, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Mir Mubashir Khalid, Shringar Rao, Ameneh Bazrafshan, Monique MA Verstegen, Farzin Pourfarzad, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles Boucher, Jan NM IJzermans, Meritxell Huch, Sylvia F Boj, Robert Vries, Hans Clevers, Luc JW van der Laan, Pantelis Hatzis, Tokameh Mahmoudi
Publikováno v:
eLife, Vol 10 (2021)
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for
Externí odkaz:
https://doaj.org/article/14b4dd868a334facbdb13052dadd9b22
Autor:
Tokameh Mahmoudi, Sylvia F Boj, Pantelis Hatzis, Vivian S W Li, Nadia Taouatas, Robert G J Vries, Hans Teunissen, Harry Begthel, Jeroen Korving, Shabaz Mohammed, Albert J R Heck, Hans Clevers
Publikováno v:
PLoS Biology, Vol 15, Iss 2, p e1002596 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.1000539.].
Externí odkaz:
https://doaj.org/article/62c1db93ed6448449dcd4f427ae3ddea
Autor:
Tokameh Mahmoudi, Sylvia F Boj, Pantelis Hatzis, Vivian S W Li, Nadia Taouatas, Robert G J Vries, Hans Teunissen, Harry Begthel, Jeroen Korving, Shabaz Mohammed, Albert J R Heck, Hans Clevers
Publikováno v:
PLoS Biology, Vol 8, Iss 11, p e1000539 (2010)
Wnt signaling maintains the undifferentiated state of intestinal crypt progenitor cells by inducing the formation of nuclear TCF4/β-catenin complexes. In colorectal cancer, activating mutations in Wnt pathway components cause inappropriate activatio
Externí odkaz:
https://doaj.org/article/645b939842eb4f87822b8f0fead8cb25
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000970 (2010)
The transcription of individual genes is determined by combinatorial interactions between DNA-binding transcription factors. The current challenge is to understand how such combinatorial interactions regulate broad genetic programs that underlie cell
Externí odkaz:
https://doaj.org/article/226553d290904bdaae8ada6e611ff453
Autor:
Ewan R Pearson, Sylvia F Boj, Anna M Steele, Timothy Barrett, Karen Stals, Julian P Shield, Sian Ellard, Jorge Ferrer, Andrew T Hattersley
Publikováno v:
PLoS Medicine, Vol 4, Iss 4, p e118 (2007)
BACKGROUND:Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperins
Externí odkaz:
https://doaj.org/article/f8920673f15d49ad8efdb48b7ed70655
Autor:
Annelotte M. Vonk, Peter van Mourik, Anabela S. Ramalho, Iris A.L. Silva, Marvin Statia, Evelien Kruisselbrink, Sylvia W.F. Suen, Johanna F. Dekkers, Frank P. Vleggaar, Roderick H.J. Houwen, Jasper Mullenders, Sylvia F. Boj, Robert Vries, Margarida D. Amaral, Kris de Boeck, Cornelis K. van der Ent, Jeffrey M. Beekman
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100019- (2020)
Summary: This protocol describes the isolation, handling, culture of, and experiments with human colon stem cell organoids in the context of cystic fibrosis (CF). In human colon organoids, the function of cystic fibrosis transmembrane conductance reg
Externí odkaz:
https://doaj.org/article/fefd7bcad3ec46998e45178ebd7ffc13
Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses
Autor:
Giulia Raimondi, Ana Mato-Berciano, Silvia Pascual-Sabater, Maria Rovira-Rigau, Miriam Cuatrecasas, Constantino Fondevila, Santiago Sánchez-Cabús, Harry Begthel, Sylvia F. Boj, Hans Clevers, Cristina Fillat
Publikováno v:
EBioMedicine, Vol 56, Iss , Pp 102786- (2020)
Background: Pancreatic patient–derived organoids (PDOs) are a well-established model for studying pancreatic ductal adenocarcinoma (PDAC) carcinogenesis and are potential predictors of clinical responses to chemotherapy. Oncolytic virotherapy is en
Externí odkaz:
https://doaj.org/article/54b0579e90bc4533acf9a74474c5a28f
Autor:
Cindy J.M. Loomans, Nerys Williams Giuliani, Jeetindra Balak, Femke Ringnalda, Léon van Gurp, Meritxell Huch, Sylvia F. Boj, Toshiro Sato, Lennart Kester, Susana M. Chuva de Sousa Lopes, Matthias S. Roost, Susan Bonner-Weir, Marten A. Engelse, Ton J. Rabelink, Harry Heimberg, Robert G.J. Vries, Alexander van Oudenaarden, Françoise Carlotti, Hans Clevers, Eelco J.P. de Koning
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 712-724 (2018)
Summary: Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that supports the expansion of adult human pancreatic tissue and the
Externí odkaz:
https://doaj.org/article/26dfd9d03dab480b970ce0861845e50f
Autor:
C. Kors van der Ent, Renske van der Meer, Sylvia F. Boj, Robert G.J. Vries, Harry G.M. Heijerman, Peter van Mourik, Paul K. Audhya, Jamie R Doyle, Jeffrey M. Beekman, Zheng Jason Yuan, N. Kinnman, Gitte Berkers
Publikováno v:
Journal of Cystic Fibrosis. 20:761-767
Background Previous in vitro organoid data showed A455E–CFTR, a rare CFTR mutation with 4.1% prevalence in the Netherlands, responds to lumacaftor/ivacaftor (LUM/IVA). We explored LUM/IVA's clinical efficacy in people with CF and ≥1 A455E–CFTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e7cd4bc1b9aa6bdfa4cf0c9c20123f
https://doi.org/10.1016/j.jcf.2020.11.007
https://doi.org/10.1016/j.jcf.2020.11.007